T. Goya, K. Horisawa, M. Udono, Y. Ohkawa, Y. Ogawa, S. Sekiya, and A. Suzuki. Direct
conversion of human endothelial cells into liver cancer-forming cells using non-integrative
episomal vectors. Hepatol. Commun. In press, 2022.

S. Katsuhara, M. Yokomoto-Umakoshi, H. Umakoshi, Y. Matsuda, N. Iwahashi, H. Kaneko, M.
Ogata, T. Fukumoto, E. Terada, R. Sakamoto, and Y. Ogawa. Impact of cortisol on reduction in
muscle strength and mass: a Mendelian randomization study. J. Clin. Endocrinol. Metab. 107:
e1477-e1487, 2022.

M. Yokomoto-Umakoshi, H. Umakoshi, N. Iwahashi, Y. Matsuda, H. Kaneko, M. Ogata, T.
Fukumoto, E. Terada, Y. Nakano, R. Sakamoto, and Y. Ogawa. Protective role of DHEAS in age-
related changes in bone mass and fracture risk: a Mendelian randomization study. J. Clin.
Endocrinol. Metab. 106: e4580-e4592, 2021.

Y. Takeichi, T. Miyazawa, S. Sakamoto, Y. Hanada, L. Wang, S. Katsuhara, R. Sakamoto, T.
Ishihara, K. Masuda, N. Ishihara, M. Nomura, and Y. Ogawa. Nonalcoholic fatty liver diseases
in mice with hepatocyte-specific deletion of mitochondrial fission factor (MFF). Diabetologia 
64: 2092-2107, 2021.

Yoshioka, M. Tanaka, K. Ochi, A. Watanabe, K. Ono, M. Sawada, T. Ogi, M. Itoh, A. Ito, Y.
Shiraki, A. Enomoto, M. Ishigami, M. Fujishiro, Y. Ogawa, and T. Suganami. The sodium-
glucose cotransporter-2 inhibitor Tofogliflozin prevents the progression of nonalcoholic
steatohepatitis-associated liver tumors in a novel murine model. EBioMedicine 140: 111738,
2021.

K. Yoshioka, H. Nagahisa, F. Miura, H. Araki, Y. Kamei, Y. Kitajima, D. Seko, J. Nogami, Y.
Tsuchiya, N. Okazaki, A. Yonekura, S. Ohba, Y. Sumita, K. Chiba, K. Ito, I. Asahina, Y. Ogawa,
T. Ito, Y. Ohkawa, and Y. Ono. Hoxa10 mediates positional memory to govern stem cell function
in adult skeletal muscle. Sci. Adv. 7: eabd7924, 2021.

H. Kaneko, H. Umakoshi, M. Ogata, N. Wada, N. Iwahashi, T. Fukumoto, M. Yokomoto-
Umakoshi, Y. Nakano, Y. Matsuda, T. Miyazawa, R. Sakamoto, and Y. Ogawa. Machine learning-
based models for prediction of subtype diagnosis of primary aldosteronism using blood test. Sci.
Rep. 11: e9140, 2021.

T. Fukuda, R. Bouchi, T. Takeuchi, K. Amo-Shiinoki, A. Kudo, S. Tanaka, M. Tanabe, T. Akashi,
K. Hirayama, T. Odamaki, M. Igarashi, I. Kimura, K. Tanabe, Y. Tanizawa, T. Yamada, and Y.
Ogawa. Importance of intestinal environment and cellular plasticity of islets in the development
of post-pancreatectomy diabetes. Diabetes Care 44: 1002-1011, 2021.

Y. Kanamori, M. Tanaka, M. Itoh, K. Ochi, A. Ito, I. Hidaka, I. Sakaida, Y. Ogawa, and T.
Suganami. Iron-rich Kupffer cells exhibit phenotypic changes during the development of liver
fibrosis in NASH. iScience 24: e102032, 2021.

T. Fukumoto, H. Umakoshi, M. Ogata, M. Yokomoto-Umakoshi, Y. Matsuda, M. Motoya, H.
Nagata, Y. Nakano, N. Iwahashi, H. Kaneko, N. Wada, T. Miyazawa, R. Sakamoto, and Y. Ogawa,
the Q-AND-A study group. Significance of discordant results between confirmatory tests in
diagnosis of primary aldosteronism. J. Clin. Endocrinol. Metab. 106: e866-e874, 2021.

K. Amo-Shiinoki, K. Tanabe, Y. Hoshii, H. Matsui, R. Harano, T. Fukuda, T. Takeuchi, R. Bouchi,
T. Takagi, M. Hatanaka, S. Okuya, W. Nishimura, A. Kudo, S. Tanaka, M. Tanabe, T. Akashi, T.
Yamada, Y. Ogawa, E. Ikeda, H. Nagano, and Y. Tanizawa. Islet cell dedifferentiation is a
pathologic mechanism of longstanding progression of type 2 diabetes. JCI Insight 6: e143791,
2021.

M. Tanaka, M. Saka-Tanaka, K. Ochi, K. Fujieda, Y. Sugiura, T. Miyamoto, H. Kohda, A. Ito, T.
Miyazawa, A. Matsumoto, S. Aoe, Y. Miyamoto, N. Tsuboi, S. Maruyama, M. Suematsu, S.
Yamasaki, Y. Ogawa, and T. Suganami. C-type lectin Mincle mediates cell death-triggered
sustained inflammation in acute kidney injury. J. Exp. Med. 217: e20192230, 2020.

Y. Minoda, E. Ihara, K. Komori, H. Ogino, Y. Otsuka, T. Chinen, Y. Tsuda, K. Ando, H.
Yamamoto, and Y. Ogawa. Efficacy of endoscopic ultrasound with artificial intelligence for the
diagnosis of gastrointestinal stromal tumors. J. Gastroenterol. 55: 1119-1126, 2020.

H. Inada, M. Udono, K. Matsuda-Ito, K. Horisawa, Y. Ohkawa, S. Miura, T. Goya, J. Yamamoto,
M. Nagasaki, K. Ueno, D. Saitou, M. Suyama, Y. Maehara, W. Kumamaru, Y. Ogawa, S. Sekiya,
and A. Suzuki. Direct reprogramming of human umbilical vein- and peripheral blood-derived
endothelial cells into hepatic progenitor cells. Nat. Commun. 11: e5292, 2020.

Y. Hanada, N. Ishihara, L. Wang, H. Otera, T. Ishihara, T. Koshiba, K. Mihara, Y. Ogawa, and M.
Nomura. Mitochondrial MAVS is energized by Mff under nutritious condition for acute antiviral
innate immune response. Nat. Commun. 11: e5711, 2020.

N. Fujimori, M. Miki, L. Lee, K. Matsumoto, Y. Takamatsu, T. Takaoka, K. Teramatsu, Y. Suehiro,
M. Murakami, H. Igarashi, T. Oono, T. Ohtsuka, M. Nakamura, Y. Koga, Y. Oda, T. Ito, and Y.
Ogawa. Natural history and clinical outcomes of pancreatic neuroendocrine neoplasms based on
the WHO 2017 classification; a single-center experience of 30 years. Pancreatology 20: 709-
715, 2020.

A. Matsumoto, H. Kuwata, S. Kimura, H. Matsumoto, K. Ochi, Y. Moro-Oka, A. Watanabe, H.
Yamada, H. Ishii, T. Miyazawa, S. Chen, T. Baba, H. Yoshida, T. Nakamura, H. Inoue, Y. Ogawa,
M. Tanaka, Y. Miyahara, and T. Suganami. Hollow fiber-combined glucose-responsive gel
technology as an in vivo electronics-free insulin delivery system. Commun. Biol. 3: e313, 2020.

R. Iwagishi, R. Tanaka, M. Seto, T. Takagi, N. Norioka, T. Ueyama, T. Kawamura, J. Takagi, Y.
Ogawa, and K. Shirakabe. Negatively charged amino acids in the stalk region of membrane
proteins reduce ectodomain shedding. J. Biol. Chem. 295: 12343-12352, 2020.

H. Umakoshi, R. Sakamoto, Y. Matsuda, M. Yokomoto-Umakoshi, H. Nagata, T. Fukumoto, M.
Ogata, and Y. Ogawa. Role of aldosterone and potassium levels in sparing confirmatory tests in
primary aldosteronism. J. Clin. Endocrinol. Metab. 105: 1284-1289, 2020.

M. Yokomoto-Umakoshi, H. Umakoshi, T. Fukumoto, Y. Matsuda, H. Nagata, M. Ogata, H.
Kawate, T. Miyazawa, R. Sakamoto, and Y. Ogawa. Pheochromocytoma and paraganglioma: an
emerging cause of secondary osteoporosis. Bone 133: 115221, 2020.

K. Shiba, K. Tsuchiya, C. Komiya, Y. Miyachi, K. Mori, N. Shimazu, S. Yamaguchi, N.
Ogasawara, M. Katoh, M. Itoh, T. Suganami, and Y. Ogawa. Canagliflozin, an SGLT2 inhibitor,
attenuates the development of hepatocellular carcinoma in a mouse model of human NASH. Sci.
Rep. 8: e2362, 2018.

X. Yuan, K. Tsujimoto, Hashimoto, K. Kawahori, N. Hanzawa, M. Hamaguchi, T. Seki, M. Nawa,
T. Ehara, Y. Kitamura, I. Hatada, M. Konishi, N. Itoh, Y. Nakagawa, H. Shimano, T. Takai-
Igarashi, Y. Kamei, and Y. Ogawa. Epigenetic modulation of Fgf21 in the perinatal mouse liver
ameliorates diet-induced obesity in adulthood. Nat. Commun. 9: e636, 2018.

N. Chiyonobu, S. Shimada, Y. Akiyama, K. Mogushi, M. Itoh, K. Akahoshi, S. Matsumura, K.
Ogawa, H. Ono, Y. Mitsunori, D. Ban, A. Kudo, S. Arii, T. Suganami, S. Yamaoka, Y. Ogawa, M.
Tanabe, and S. Tanaka. FABP4 overexpressed in intratumoral hepatic stellate cells within
hepatocellular carcinoma with metabolic risk factors. Am. J. Pathol. 188: 1213-1224, 2018.

K. Kawahori, K. Hashimoto, X. Yuan, K. Tsujimoto, N. Hanzawa, M. Hamaguchi, S. Kase, K.
Fujita, K. Tagawa, H. Okazawa, Y. Nakajima, N. Shibusawa, M. Yamada, and Y. Ogawa. Mild
maternal hypothyroxinemia during pregnancy induces persistent DNA hypermethylation in the
hippocampal brain-derived neurotrophic factor gene in mouse offspring. Thyroid 28: 395-406,
2018.

T. Fukuda, R. Bouchi, T. Takeuchi, K. Tsujimoto, I. Minami, T. Yoshimoto, and Y. Ogawa.
Sarcopenic obesity assessed using dual energy X-ray absorptiometry (DXA) can predict
cardiovascular disease in patients with type 2 diabetes: a retrospective observational study. 
Cardiovasc. Diabetol. 17: e55, 2018.

A. Mukaino, H. Minami, H. Isomoto, H. Hamamoto, E. Ihara, Y. Maeda, O. Higuchi, T. Okanishi,
T. Yokota, Y. Kokudo, K. Deguchi, F. Sasaki, T. Ueki, K. Murata, T. Yoshida, M. Kinjo, Y. Ogawa,
A. Ido, H. Matsuo, K. Nakao, and S. Nakane. Anti-ganglionic acetylcholine receptor antibodies
in Japanese patients with motility disorders. J. Gastroenterol. 53: 1227-1240, 2018.

Y. Miyachi, K. Tsuchiya, K. Shiba, K. Mori, C. Komiya, N. Ogasawara, and Y. Ogawa. A reduced
M1-like/M2-like ratio of macrophages in healthy adipose tissue expansion during SGLT2
inhibition. Sci. Rep. 8: e16113, 2018.

Y. Akehi, T. Yanase, R. Motonaga, H. Umakoshi, M. Tsuiki, Y. Takeda, T. Yoneda, I. Kurihara, H.
Itoh, T. Katabami, T. Ichijo, N. Wada, Y. Shibayama, T. Yoshimoto, K. Ashida, Y. Ogawa, J.
Kawashima, M. Sone, N. Inagaki, K. Takahashi, M. Fujita, M. Watanabe, Y. Matsuda, H.
Kobayashi, H. Shibata, K. Kamemura, M. Otsuki, Y. Fujii, K. Yamamoto, A. Ogo, S. Okamura,
S. Miyauchi, T. Fukuoka, S. Izawa, S. Hashimoto, M. Yamada, Y. Yoshikawa, T. Kai, T. Suzuki,
T. Kawamura, and M. Naruse. High prevalence of diabetes in patients with primary aldosteronism
(PA) associated with subclinical hypercortisolism and prediabetes more prevalent in bilateral than
unilateral PA: a large multicenter cohort study in Japan. Diabetes Care 42: 938-945, 2018.

K. Hashimoto, E. Nishihara, M. Matsumoto, S. Matsumoto, Y. Nakajima, K. Tsujimoto, H.
Yamakage, N. Asahara-Satoh, J. Noh, K. Ito, A. Miyauchi, M. Mori, M. Yamada, and Y. Ogawa.
Sialic acid-binding immunoglobulin-like lectin1 as a novel predictive biomarker for relapse in
Graves’ disease: a multicenter study. Thyroid 28: 50-59, 2018.

A. Matsumoto, M. Tanaka, H. Matsumoto, K. Ochi, Y. Moro-oka, H. Kuwata, H. Yamada, I.
Shirakawa, T. Miyazawa, H. Ishii, K. Kataoka, Y. Ogawa, Y. Miyahara, and T. Suganami.
Synthetic "smart gel" provides glucose-responsive insulin delivery in diabetic mice. Sci. Adv. 3,
eaaq0723, 2017.

M. Itoh, T. Suganami, S. Kanai, I. Shirakawa, T. Sakai, T. Goto, M. Asakawa, I. Hidaka, Y.
Komohara, K. Asano, I. Sakaida, M. Tanaka, and Y. Ogawa. CD11c⁺ resident macrophages drive
hepatocyte death-triggered liver fibrosis in a murine model of nonalcoholic steatohepatitis. JCI
Insight 2: e92902, 2017.

E.A. Coutinho, S. Okamoto, A. Ishikawa, S. Yokota, N. Wada, T. Hirabayashi, K. Saito,
T. Sato, K. Takagi, C.-C. Wang, K. Kobayashi, Y. Ogawa, S. Shioda, Y. Yoshimura, and Y. Minokoshi.
Activation of SF1 neurons in the ventromedial hypothalamus by DREADD technology increases
insulin sensitivity in peripheral tissues. Diabetes 66: 2372-2386, 2017.

N. Miyamura, S. Hata, T. Itoh, M. Tanaka, M. Nishio, M. Itoh, Y. Ogawa, S. Terai, I. Sakaida, A.
Suzuki, A. Miyajima, and H. Nishina. YAP determines the cell fate of injured mouse hepatocytes
in vivo. Nat. Commun. 8: e16017, 2017.

K. Shirakabe, T. Omura, Y. Shibagaki, E. Mihara, K. Homma, Y. Kato, A. Yoshimura, Y.
Murakami, J. Takagi, S. Hattori, and Y. Ogawa. Mechanistic insights into ectodomain shedding:
susceptibility of CADM1 adhesion molecule is determined by alternative splicing and O-
glycosylation. Sci. Rep. 7: e46174, 2017.

Y. Miyachi, K. Tsuchiya, C. Komiya, K. Shiba, N. Shimazu, S. Yamaguchi, M. Deushi, M. Osaka,
K. Inoue, Y. Sato, S. Matsumoto, J. Kikuta, K. Wake, M. Yoshida, M. Ishii, and Y. Ogawa. Roles
of cell-cell adhesion and contact in obesity-induced hepatic myeloid cell accumulation and
glucose intolerance. Cell Rep. 18: 2766-2779, 2017.

C. Komiya, M. Tanaka, K. Tsuchiya, N. Shimazu, S. Furuke, Y. Miyachi, K. Shiba, S. Yamaguchi,
K. Ikeda, K. Ochi, K. Nakabayashi, K. Hata, M. Itoh, T. Suganami, and Y. Ogawa. Antifibrotic
effect of pirfenidone in a mouse model of human nonalcoholic steatohepatitis. Sci. Rep. 7:
e44754, 2017.

C. Komiya, K. Tsuchiya, K. Shiba, Y. Miyachi, S. Furuke, N. Shimazu, S. Yamaguchi, K. Kanno,
and Y. Ogawa. Ipragliflozin improves hepatic steatosis in obese mice and liver dysfunction in
type 2 diabetic patients irrespective of body weight reduction. PLoS ONE 11: e0151511, 2016.

K. Muramatsu-Kato, H. Itoh, Y. Kohmura-Kobayashi, N. Tamura, C. Yaguchi, T. Uchida, K.
Suzuki, K. Hashimoto, T. Suganami, Y. Ogawa, and N. Kanayama. Undernourishment in utero
primes hepatic steatosis in adult mice offspring on an obesogenic diet: involvement of
endoplasmic reticulum stress. Sci. Rep. 5: e16867, 2015.

M. Takagi, H. Uno, R. Nishi, M. Sugimoto, S. Hasegawa, J. Piao, N. Ihara, S. Kanai, S. Kakei,
Y. Tamura, T. Suganami, Y. Kamei, T. Shimizu, A. Yasuda, Y. Ogawa, and S. Mizutani. ATM
regulates adipocyte differentiation and contributes to glucose homeostasis. Cell Rep. 10: 1-11,
2015.

T. Ehara, Y. Kamei, X. Yuan, M. Takahashi, S. Kanai, E. Tamura, K. Tsujimoto, T. Tamiya, Y.
Nakagawa, H. Shimano, T. Takai-Igarashi, I. Hatada, T. Suganami, K. Hashimoto, andY. Ogawa.
Ligand-activated PPARa-dependent DNA demethylation regulates the fatty acid b-oxidation
genes in the postnatal liver. Diabetes 64: 775-784, 2015. 

J. Park, Y.-S. Yoon, H.-S. Han, Y. H. Kim, Y. Ogawa, K.-G. Park, C. H. Lee, S.-T. Kim, and S.-
H. Koo. SIK2 is critical in the regulation of lipid homeostasis and adipogenesis in vivo. Diabetes
 63: 3659-3673, 2014.

M. Tanaka, K. Ikeda, T. Suganami, C. Komiya, K. Ochi, I. Shirakawa, M. Hamaguchi, S.
Nishimura, I. Manabe, T. Matsuda, K. Kimura, H. Inoue, Y. Inagaki, S. Aoe, S. Yamasaki, and Y.
Ogawa. Macrophage-inducible C-type lectin underlies obesity-induced adipose tissue fibrosis. 
Nat. Commun. 5: e4982, 2014.

N. Sawada, A. Jiang, F. Takizawa, A. Safdar, A. Manika, Y. Tesmenitsky, K.-T. Kang, J. Bischoff,
H. Kalwa, J.L. Sartoretto, Y. Kamei, L.E. Benjamin, H. Watada, Y. Ogawa, Y. Higashikuni, C.W.
Kessinger, F.A. Jaffer, T. Michel, M. Sata, K. Croce, R. Tanaka, and Z. Arany. Endothelial PGC-
1a mediates vascular dysfunction in diabetes. Cell Metab. 19: 246-258, 2014.

Y. Iwasaki, T. Suganami, R. Hachiya, I. Shirakawa, M. Kim-Saijo, M. Tanaka, M. Hamaguchi, T.
Takai-Igarashi, M. Nakai, Y. Miyamoto, and Y. Ogawa. Activating transcription factor 4 links
metabolic stress to interleukin-6 expression in macrophages. Diabetes 63: 152-161, 2014.

M. Itoh, H. Kato, T. Suganami, K. Konuma, Y. Marumoto, S. Terai, H. Sakugawa, S. Kanai, M.
Hamaguchi, T. Fukaishi, K. Akiyoshi, Y. Komohara, M. Takeya, I. Sakaida, and Y. Ogawa.
Hepatic crown-like structure: a unique histological feature in non-alcoholic steatohepatitis in
mice and humans. PLoS ONE 8: e82163, 2013.

S. Yogosawa, S. Mizutani, Y. Ogawa, and T. Izumi. Activin receptor-like kinase 7 suppresses
lipolysis to accumulate fat in obesity through downregulation of peroxisome proliferator-
activated receptorγ and C/EBPa. Diabetes 62: 115-123, 2013.

N. Satoh-Asahara, A. Shimatsu, Y. Sasaki, H. Nakaoka, A. Himeno, M. Tochiya, S. Kono, T.
Takaya, H. Wada, T. Suganami, K. Hasegawa, and Y. Ogawa. Highly purified eicosapentaenoic
acid increases interleukin-10 levels of peripheral blood monocytes in obese patients with dyslipidemia. Diabetes Care 35: 2631-2639, 2012.

T. Ehara, Y. Kamei, M. Takahashi, X. Yuan, S. Kanai, E. Tamura, M. Tanaka, T. Yamazaki, O.
Ezaki, T. Suganami, M. Okano, and Y. Ogawa. Role of DNA methylation in the regulation of
lipogenic gene expression in the neonatal mouse liver. Diabetes 61: 2442-2450, 2012.

Y. Watanabe, T. Nakamura, S. Ishikawa, S. Fujisaka, I. Usui, K. Tsuneyama, Y. Ichihara, T. Wada,
Y. Hirata, T. Suganami, H. Izaki, S. Akira, K. Miyake, H. Kanayama, M. Shimabukuro, M. Sata,
T. Sasaoka, Y. Ogawa, K. Tobe, K. Takatsu, and Y. Nagai. The Radioprotective 105/MD-1
complex contributes to diet-induced obesity and adipose tissue inflammation. Diabetes 61: 1199-
1209, 2012.

M. Itoh, T. Suganami, N. Nakagawa, M. Tanaka, Y. Yamamoto, Y. Kamei, S. Terai, I. Sakaida,
and Y. Ogawa. Melanocortin-4 receptor-deficient mice as a novel mouse model of non-alcoholic
steatohepatitis. Am. J. Pathol. 179: 2454-2463, 2011.

M. Tanaka, T. Suganami, M. Kim-Saijo, C. Toda, M. Tsuiji, K. Ochi, Y. Kamei, Y. Minokoshi,
and Y. Ogawa. Role of central leptin signaling in the starvation-induced alteration of B cell
development. J. Neurosci. 31: 8373-8380, 2011.

M. Ichioka, T. Suganami, N. Tsuda, I. Shirakawa, Y. Hirata, N. Satoh-Asahara, Y. Shimoda, M.
Tanaka, M. Kim-Saijo, Y. Miyamoto, Y. Kamei, M. Sata, and Y. Ogawa. Increased expression of
macrophage-inducible C-type lectin in adipose tissue of obese mice and humans. Diabetes 60:
819-826, 2011.

A. Sato, H. Kawano, T. Notsu, M. Ohta, M. Nakakuki, K. Mizuguchi, M. Itoh, T. Suganami, and Y. Ogawa. Anti-obesity effect of eicosapentaenoic acid in high-fat/high-sucrose diet-induced obesity: importance of hepatic lipogenesis. Diabetes 59: 2495-2504, 2010.

N. Satoh, A. Shimatsu, A. Himeno, Y. Sasaki, H. Yamakage, K. Yamada, T. Suganami, and Y.
Ogawa. Unbalanced M1/M2 phenotype of peripheral blood monocytes in obese diabetic patients:
effect of pioglitazone. Diabetes Care 33: e7, 2010.

T. Suganami, X. Yuan, Y. Shimoda, K. Uchio-Yamada, N. Nakagawa, I. Shirakawa, T. Usami, T.
Tsukahara, K. Nakayama, Y. Miyamoto, K. Yasuda, J. Matsuda, Y. Kamei, S. Kitajima, and Y.
Ogawa. Activating transcription factor 3 constitutes a negative feedback mechanism that
attenuates saturated fatty acid/Toll-like receptor 4 signaling and macrophage activation in obese
adipose tissue. Circ. Res. 105: 25-32, 2009.

A. Ito, T. Suganami, A. Yamauchi, M. Degawa-Yamauchi, M. Tanaka, R. Kouyama, Y. Kobayashi,
N. Nitta, K. Yasuda, Y. Hirata, W. A. Kuziel, M. Takeya, S. Kanegasaki, Y. Kamei, and Y. Ogawa.
Role of C-C chemokine receptor 2 in bone marrow cells in the recruitment of macrophages into
obese adipose tissue. J. Biol. Chem. 283: 35715-35723, 2008.

R. Hachiya, Y. Ohashi, Y. Kamei, T. Suganami, H. Mochizuki, N. Mitsui, M. Saitoh, M. Sakuragi,
G. Nishimura, H. Ohashi, T. Hasegawa, and Y. Ogawa. Intact kinase homology domain of
natriuretic peptide receptor-B is essential for skeletal development. J. Clin. Endocrinol. Metab. 
92: 4009-4014, 2007.

M. Itoh, T. Suganami, N. Satoh, K. Tanimoto-Koyama, X. Yuan, M. Tanaka, H. Kawano, T. Yano,
S. Aoe, M. Takeya, A. Shimatsu, H. Kuzuya, Y. Kamei, and Y. Ogawa. Increased adiponectin
secretion by highly purified eicosapentaenoic acid in rodent models of obesity and human obese
subjects. Arterioscler. Thromb. Vasc. Biol. 27: 1918-1925, 2007.

K. Ebihara, T. Kusakabe, M. Hirata, H. Masuzaki, F. Miyanaga, N. Kobayashi, T. Tanaka, H.
Chusho, T. Miyazawa, T. Hayashi, K. Hosoda, Y. Ogawa, A.M. Depaoli, M. Fukushima, and K.
Nakao. Efficacy and safety of leptin-replacement therapy and possible mechanisms of leptin
actions in patients with generalized lipodystrophy. J. Clin. Endocrinol. Metab. 92: 532-541,
2007.

N. Satoh, A. Shimatsu, K. Kotani, N. Sakane, K. Yamada, T. Suganami, H. Kuzuya, and Y. Ogawa.
Purified eicosapentaenoic acid reduces small dense LDL, remnant lipoprotein particles, and C-
reactive protein in metabolic syndrome. Diabetes Care 30: 144-146, 2007.

T. Suganami, K. Tanimoto-Koyama, J. Nishida, M. Itoh, X. Yuan, S. Mizuarai, H. Kotani, S.
Yamaoka, K. Miyake, S. Aoe, Y. Kamei, and Y. Ogawa. Role of the Toll-like receptor 4/NF-kB
pathway in saturated fatty acid-induced inflammatory changes in the interaction between
adipocytes and macrophages. Arterioscler. Thromb. Vasc. Biol. 27: 84-91, 2007.

J. Park, S. S. Choe, A. H. Choi, K. H. Kim, M. J. Yoon, N. Houstis, E. D. Rogen, T. Suganami, 
Y. Ogawa, and J. B. Kim. Increase in glucose-6-phosphate dehydrogenase in adipocytes
stimulates oxidative stress and inflammatory signal. Diabetes 55: 2939-2949, 2006.

T. Suganami, J. Nishida, and Y. Ogawa. A paracrine loop between adipocytes and macrophages
aggravates inflammatory changes: role of free fatty acids and tumor necrosis factor α. 
Arterioscler. Thromb. Vasc. Biol. 25: 2062-2068, 2005.

T. Tanaka, S. Hidaka, H. Masuzaki, S. Yasue, Y. Minokoshi, K. Ebihara, H. Chusho, Y. Ogawa,
T. Toyoda, K. Sato, F. Miyanaga, M. Fujimoto, T. Tomita, T. Kusakabe, N. Kobayashi, H. Tanioka,
T. Hayashi, K. Hosoda, H. Yoshimatsu, T. Sakata, and K. Nakao. Skeletal muscle AMPK
phosphorylation parallels metabolic phenotypes in leptin transgenic mice under dietary
modification. Diabetes 54: 2365-2374, 2005.

S. Yura, H. Itoh, N. Sagawa, H. Yamamoto, H. Masuzaki, K. Nakao, M. Kawamura, M. Takemura,
K. Kakui, Y. Ogawa, and S. Fujii. Role of premature leptin surge in obesity resulting from
intrauterine undernutrition. Cell Metab. 1: 371-378, 2005.

Y. Oike, M. Akao, K. Yasunaga, T. Yamauchi, T. Morisada, Y. Ito, T. Urano, Y. Kimura, Y. Kubota,
H. Maekawa, T. Miyamoto, K. Miyata, S. Matsumoto, J. Sakai, N. Nakagata, M. Takeya, H.
Koseki, Y. Ogawa, T. Kadowaki, and T. Suda. Angiopoietin-related growth factor antagonizes
obesity and insulin resistance. Nat. Med. 11: 400-408, 2005.

R. Kawakami, Y. Saito, I. Kishimoto, M. Harada, K. Kuwahara, N. Takahashi, Y. Nakagawa, M.
Nakanishi, K. Tanimoto, S. Usami, S. Yasuno, H. Kinoshita, H. Chusho, N. Tamura, Y. Ogawa,
and K. Nakao. Overexpression of brain natriuretic peptide facilitates neutrophil infiltration and
cardiac matrix metalloproteinase-9 expression after acute myocardial infarction. Circulation 
110: 3306-3312, 2004.

N. Satoh, M. Naruse, T. Usui, T. Tagami, T. Suganami, K. Yamada, H. Kuzuya, A. Shimatsu, and 
Y. Ogawa. Leptin-to-adiponectin ratio as a potential atherogenic index in obese type 2 diabetic
patients. Diabetes Care 27: 2488-2490, 2004.

E. Suganami, H. Takagi, H. Ohashi, K. Suzuma, I. Suzuma, H. Oh, D. Watanabe, T. Ojima, T.
Suganami, Y. Fujio, K. Nakao, Y. Ogawa, and N. Yoshimura. Leptin stimulates ischemia-induced
retinal neovascularization: possible role of vascular endothelial growth factor expressed in retinal
endothelial cells. Diabetes 53: 2443-2448, 2004.

K. Ebihara, T. Kusakabe, H. Masuzaki, N. Kobayashi, T. Tanaka, H. Chusho, F. Miyanaga, T.
Miyazawa, T. Hayashi, K. Hosoda, Y. Ogawa, and K. Nakao. Gene and phenotype analysis of
congenital generalized lipodystrophy in Japanese: a novel homozygous nonsense mutation in
seipin gene. J. Clin. Endocrinol. Metab. 89: 2360-2364, 2004.

F. Elefteriou, S. Takeda, K. Ebihara, J. Magre, N. Patano, C. Ae Kim, Y. Ogawa, X. Liu, S. M.
Ware, W. J. Craigen, J. J. Robert, C. Vinson, K. Nakao, J. Capeau, and G. Karsenty. Serum leptin
level is a regulator of bone mass. Proc. Natl. Acad. Sci. USA 101: 3258-3263, 2004.

A. Yasoda, Y. Komatsu, H. Chusho, T. Miyazawa, A. Ozasa, M. Miura, T. Kurihara, T. Rogi, S.
Tanaka, M. Suda, N. Tamura, Y. Ogawa, and K. Nakao. Overexpression of CNP in chondrocytes
rescues achondroplasia through a MAPK-dependent pathway. Nat. Med. 10: 80-86, 2004.

F. Miyanaga, Y. Ogawa, K. Ebihara, S. Hidaka, T. Tanaka, S. Hayashi, H. Masuzaki, and K.
Nakao. Leptin as an adjunct of insulin therapy in insulin-dependent diabetes. Diabetologia 46:
1329-1337, 2003.

N. Satoh, Y. Ogawa, T. Usui, T. Tagami, S. Kohno, H. Uesugi, H. Sugiyama, A. Sugawara, K.
Yamada, A. Shimatsu, H. Kuzuya, and K. Nakao. Antiatherogenic effect of pioglitazone in type
2 diabetic patients irrespective of the responsiveness to its antidiabetic effect. Diabetes Care 26:
2493-2499, 2003.

K. Yamahara, H. Itoh, T.-H. Chun, Y. Ogawa, J. Yamashita, N. Sawada, Y. Fukunaga, M. Sone,
T. Yurugi-Kobayashi, K. Miyashita, H. Tsujimoto, H. Kook, R. Feil, D.L. Garbers, F. Hofmann,
and K. Nakao. Significance and therapeutic potential of the natriuretic peptides/cGMP/cGMP-
dependent protein kinase pathway in vascular regeneration. Proc. Natl. Acad. Sci. USA 100:
3404-3409, 2003.

H. Kobayashi, Y. Ogawa, M. Shintani, K. Ebihara, M. Shimodahira, T. Iwakura, M. Hino, T.
Ishihara, K. Ikekubo, H. Kurahachi, and K. Nakao. A novel homozygous missense mutation of
melanocortin-4 receptor (MC4R) in a Japanese woman with severe obesity. Diabetes 51: 243-
246, 2002.

H. Ariyasu, K. Takaya, T. Tagami, Y. Ogawa, K. Hosoda, T. Akamizu, M. Suda, T. Koh, K.  
Natsui, S. Toyooka, G. Shirakami, T. Usui, A. Shimatsu, K. Doi, H. Hosoda, M. Kojima, K.
Kangawa, and K. Nakao. Stomach is a major source of circulating ghrelin and feeding state determines plasma ghrelin-like immunoreactivity levels in humans. J. Clin. Endocrinol. Metab. 
86: 4753-4758, 2001.

M. Shintani, H. Nishimura, S. Yonemitsu, Y. Ogawa, T. Hayashi, K. Hosoda, G. Inoue, and K.
Nakao. Troglitazone not only increases GLUT4 but also induces its translocation in rat adipocytes. 
Diabetes 50: 2296-2300, 2001.

K. Ebihara, Y. Ogawa, H. Masuzaki, M. Shintani, F. Miyanaga, M. Aizawa-Abe, T. Hayashi, K.
Hosoda, G. Inoue, Y. Yoshimasa, O. Gavrilova, M. L. Reitman, and K. Nakao. Transgenic
overexpression of leptin rescues insulin resistance and diabetes in a mouse model of lipoatrophic
diabetes. Diabetes 50: 1440-1448, 2001.

S. Yonemitsu, H. Nishimura, M. Shintani, R. Inoue, Y. Yamamoto, H. Masuzaki, Y. Ogawa, T.
Hayashi, K. Hosoda, G. Inoue, and K. Nakao. Troglitazone induces GLUT4 translocation in L6
myotubes. Diabetes 50: 1093-1101, 2001.

H. Chusho, N. Tamura, Y. Ogawa, A. Yasoda, M. Suda, T. Miyazawa, K. Nakamura, K. Nakao,
T. Kurihara, Y. Komatsu, H. Itoh, K. Tanaka, Y. Saito, M. Katsuki, and K. Nakao. Dwarfism and
early death in mice lacking C-type natriuretic peptide. Proc. Natl. Acad. Sci. USA 98: 4016-
4021, 2001.

M. Shintani, Y. Ogawa, K. Ebihara, M. Aizawa-Abe, F. Miyanaga, K. Takaya, T. Hayashi, G.
Inoue, K. Hosoda, M. Kojima, K. Kangawa, and K. Nakao. Ghrelin, an endogenous growth
hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the
activation of hypothalamic neuropeptide Y/Y1 receptor pathway. Diabetes 50: 227-232, 2001.

T. Kuramoto, K. Kitada, T. Inui, Y. Sasaki, K. Ito, T. Hase, S. Kawaguchi, Y. Ogawa, K. Nakao,
G. S. Barsh, M. Nagao, T. Ushijima, and T. Serikawa. Attractin/mahogany/zitter plays a critical
role in myelination of the central nervous system. Proc. Natl. Acad. Sci. USA 98: 559-564, 2001.

M. Aizawa-Abe, Y. Ogawa, H. Masuzaki, K. Ebihara, N. Satoh, H. Iwai, N. Matsuoka, T. Hayashi,
K. Hosoda, G. Inoue, Y. Yoshimasa, and K. Nakao. Pathophysiological role of leptin in obesity-
related hypertension. J. Clin. Invest. 105: 1243-1252, 2000.

N. Tamura, Y. Ogawa, H. Chusho, K. Nakamura, K. Nakao, M. Suda, M. Kasahara, R. Hashimoto,
G. Katsuura, M. Mukoyama, H. Itoh, Y. Saito, I. Tanaka, H. Otani, M. Katsuki, and K. Nakao.
Cardiac fibrosis in mice lacking brain natriuretic peptide. Proc. Natl. Acad. Sci. USA 97: 4239-
4244, 2000.

S. Yura, Y. Ogawa, N. Sagawa, H. Masuzaki, H. Itoh, K. Ebihara, M. Aizawa-Abe, S. Fujii, and
K. Nakao. Accelerated puberty and late-onset hypothalamic hypogonadism in female transgenic
skinny mice overexpressing leptin. J. Clin. Invest. 105: 749-755, 2000.

Y. Yamamoto, Y. Yoshimasa, M. Koh, J. Suga, H. Masuzaki, Y. Ogawa, K. Hosoda, H. Nishimura,
Y. Watanabe, G. Inoue, and K. Nakao. Constitutively active mitogen-activated protein kinase
kinase increases GLUT1 expression and recruits both GLUT1 and GLUT4 at the cell surface in
3T3-L1 adipocytes. Diabetes 49: 332-339, 2000.

K. Ebihara, Y. Ogawa, G. Katsuura, Y. Numata, H. Masuzaki, N. Satoh, M. Tamaki, T. Yoshioka,
M. Hayase, N. Matsuoka, M. Aizawa-Abe, Y. Yoshimasa, and K. Nakao. Involvement of agouti-
related protein, an endogenous antagonist of hypothalamic melanocortin receptor, in leptin action. 
Diabetes 48: 2028-2033, 1999.

Y. Ogawa, H. Masuzaki, K. Hosoda, M. Aizawa-Abe, J. Suga, M. Suda, K. Ebihara, H. Iwai, N.
Matsuoka, N. Satoh, H. Odaka, H. Kasuga, Y. Fujisawa, G. Inoue, H. Nishimura, Y. Yoshimasa,
and K. Nakao. Increased glucose metabolism and insulin sensitivity in transgenic skinny mice
overexpressing leptin. Diabetes 48: 1822-1829, 1999.

N. Satoh, Y. Ogawa, G. Katsuura, Y. Numata, T. Tsuji, M. Hayase, K. Ebihara, H. Masuzaki, K.
Hosoda, Y. Yoshimasa, and K. Nakao. Sympathetic activation of leptin via the ventromedial
hypothalamus: leptin-induced increase in catecholamine secretion. Diabetes 48: 1787-1793,
1999.

H. Masuzaki, Y. Ogawa, M. Aizawa-Abe, K. Hosoda, J. Suga, K. Ebihara, N. Satoh, H. Iwai, G.
Inoue, H. Nishimura, Y. Yoshimasa, and K. Nakao. Glucose metabolism and insulin sensitivity
in transgenic mice overexpressing leptin with lethal yellow agouti mutation: usefulness of leptin
for the treatment of obesity-associated diabetes. Diabetes 48: 1615-1622, 1999.

K. Chin, K. Shimizu, T. Nakamura, N. Narai, H. Masuzaki, Y. Ogawa, M. Mishima, T. Nakamura,
K. Nakao, and M. Ohi. Changes in intra-abdominal visceral fat and serum leptin levels in patients
with obstructive sleep apnea syndrome following nasal continuous positive airway pressure
therapy. Circulation 100: 706-712, 1999.

M. Nakayama, H. Yasue, M. Yoshimura, Y. Shimasaki, K. Kugiyama, H. Ogawa, T. Motoyama,
Y. Saito, Y. Ogawa, Y. Miyamoto, and K. Nakao. T-786→C mutation in the 5'-flanking region of
the endothelial nitric oxide synthase gene is associated with coronary spasm. Circulation 99:
2864-2870, 1999.

M. Inoue, H. Itoh, M. Ueda, Y. Naruko, A. Kojima, R. Komatsu, K. Doi, Y. Ogawa, N. Tamura,
K. Takaya, T. Igaki, J. Yamashita, T.-H. Chun, K. Masatsugu, A.E. Becker, and K. Nakao.
Vascular endothelial growth factor (VEGF) expression in human coronary atherosclerotic lesions:
possible pathophysiological significance of VEGF in progression of atherosclerosis. Circulation 
98: 2108-2116, 1998.

A. Yasoda, Y. Ogawa, M. Suda, N. Tamura, K. Mori, Y. Sakuma, H. Chusho, K. Shiota, K. Tanaka,
and K. Nakao. Natriuretic peptide regulation of endochondral ossification: evidence for possible
roles of C-type natriuretic peptide/guanylyl cyclase-B pathway. J. Biol. Chem. 273: 11695-11700,
1998.

M. Suda, Y. Ogawa, K. Tanaka, N. Tamura, A. Yasoda, T. Takigawa, M. Uehira, H. Nishimoto,
H. Itoh, Y. Saito, K. Shiota, and K. Nakao. Skeletal overgrowth in transgenic mice that
overexpress brain natriuretic peptide. Proc. Natl. Acad. Sci. USA 95: 2337-2342, 1998.

M. Harada, H. Itoh, O. Nakagawa, Y. Ogawa, Y. Miyamoto, K. Kuwahara, E. Ogawa, T. Igaki, J.
Yamashita, I. Masuda, T. Yoshimasa, I. Tanaka, Y. Saito, and K. Nakao. Significance of
ventricular myocytes and nonmyocytes interaction during cardiocyte hypertrophy: evidence for
endothelin-1 as a paracrine hypertrophic factor from cardiac nonmyocytes. Circulation 96: 3737-
3744, 1997.

N. Sagawa, T. Mori, H. Masuzaki, Y. Ogawa, and K. Nakao. Leptin production by hydatidiform
mole. Lancet 350: 1518-1519, 1997.

H. Masuzaki, Y. Ogawa, N. Sagawa, K. Hosoda, T. Matsumoto, H. Mise, H. Nishimura, Y.
Yoshimasa, I. Tanaka, T. Mori, and K. Nakao. Nonadipose tissue production of leptin: leptin as a
novel placenta-derived hormone in humans. Nat. Med. 3: 1029-1033, 1997.

N. Matsuoka, Y. Ogawa, K. Hosoda, J. Matsuda, H. Masuzaki, T. Miyawaki, N. Azuma, K. Natsui,
H. Nishimura, Y. Yoshimasa, S. Nishi, D.B. Thompson, and K. Nakao. Human leptin receptor
gene in Japanese obese subjects: evidence against either obesity-causing mutations or association
of sequence variants with obesity. Diabetologia 40: 1204-1210, 1997.

H. Masuzaki, Y. Ogawa, K. Hosoda, T. Miyawaki, I. Hanaoka, J. Hiraoka, A. Yasuno, H.
Nishimura, Y. Yoshimasa, S. Nishi, and K. Nakao. Glucocorticoid regulation of leptin synthesis
and secretion in humans: elevated plasma leptin levels in Cushing’s syndrome. J. Clin.
Endocrinol. Metab. 82: 2542-2548, 1997. 

K. Takaya, Y. Ogawa, J. Hiraoka, K. Hosoda, R. J. Koletsky, Y. Yamori, and K. Nakao. Nonsense
mutation of leptin receptor in the obese spontaneously hypertensive Koletsky rat. Nat. Genet. 
14: 130-131, 1996.

K. Takaya, Y. Ogawa, N. Isse, T. Okazaki, N. Satoh, H. Masuzaki, K. Mori, N. Tamura, K.Hosoda,
and K. Nakao. Molecular cloning of rat leptin receptor isoform complementary DNAs:
identification of a missense mutation in Zucker fatty (fa/fa) rats. Biochem. Biophys. Res.
Commun. 225: 75-83, 1996.

N. Hama, H. Itoh, G. Shirakami, O. Nakagawa, S. Suga, Y. Ogawa, I. Masuda, K. Nakanishi, T.
Yoshimasa, Y. Hashimoto, M. Yamaguchi, R. Hori, H. Yasue, and K. Nakao. Rapid ventricular
induction of brain natriuretic peptide gene expression in experimental acute myocardial infarction. 
Circulation 92: 1558-1564, 1995.

Y. Ogawa, H. Masuzaki, N. Isse, T. Okazaki, K. Mori, M. Shigemoto, N. Satoh, N. Tamura, K.
Hosoda, Y. Yoshimasa, H. Jingami, T. Kawada, and K. Nakao. Molecular cloning of rat obese 
cDNA and augmented gene expression in genetically obese Zucker fatty (fa/fa) rats. J. Clin.
Invest. 96: 1647-1652, 1995.

Nakagawa, Y. Ogawa, H. Itoh, S. Suga, Y. Komatsu, I. Kishimoto, K. Nishino, T. Yoshimasa, and
K. Nakao. Rapid transcriptional activation and early mRNA turnover of brain natriuretic peptide
in cardiocyte hypertrophy: Evidence for brain natriuretic peptide as an "emergency" cardiac
hormone against ventricular overload. J. Clin. Invest. 96: 1280-1287, 1995.

H. Masuzaki, Y. Ogawa, N. Isse, N. Satoh, T. Okazaki, M. Shigemoto, K. Mori, N. Tamura, K.
Hosoda, Y. Yoshimasa, H. Jingami, T. Kawada, and K. Nakao. Human obese gene expression:
adipocyte-specific expression and regional differences in the adipose tissue. Diabetes 44: 855-
858, 1995.

H. Masuzaki, Y. Ogawa, M. Shigemoto, N. Satoh, K. Mori, N. Tamura, K. Hosoda, Y. Yoshimasa,
H. Jingami, and K. Nakao. Adipose tissue-specific expression of the obese (ob) gene in rats and
its marked augmentation in genetically obese-hyperglycemic Wistar fatty rats. Proc. Jpn. Acad.
Ser. B. 71: 148-152, 1995.

N. Tamura, Y. Ogawa, H. Itoh, H. Arai, S. Suga, O. Nakagawa, Y. Komatsu, I. Kishimoto, K.
Takaya, T. Yoshimasa, S. Shiono, and K. Nakao. Molecular cloning of hamster brain and atrial
natriuretic peptide cDNAs: cardiomyopathic hamsters are useful models for brain and atrial
natriuretic peptides. J. Clin. Invest. 94: 1059-1068, 1994.

Y. Ogawa, H. Itoh, N. Tamura, S. Suga, T. Yoshimasa, M. Uehira, S. Matsuda, S. Shiono, H.
Nishimoto, and K. Nakao. Molecular cloning of the complementary DNA and gene that encode
mouse brain natriuretic peptide and generation of transgenic mice that overexpress the brain
natriuretic peptide gene. J. Clin. Invest. 93: 1911-1921, 1994.

H. Imura, K. Nakao, A. Shimatsu, Y. Ogawa, T. Sando, I. Fujisawa, and H. Yamabe. Lymphocytic
infundibuloneurohypophysitis as a cause of central diabetes insipidus. N. Engl. J. Med. 329:
683-689, 1993.

Y. Komatsu, K. Nakao, H. Itoh, S. Suga, Y. Ogawa, and H. Imura. Vascular natriuretic peptide. 
Lancet 340: 622, 1992.

S. Suga, K. Nakao, H. Itoh, Y. Komatsu, Y. Ogawa, N. Hama, and H. Imura. Endothelial
production of C-type natriuretic peptide and its marked augmentation by transforming growth
factor-b: possible existence of "vascular natriuretic peptide system". J. Clin. Invest.90: 1145-
1149, 1992.

S. Suga, K. Nakao, I. Kishimoto, K. Hosoda, M. Mukoyama, H. Arai, G. Shirakami, Y. Ogawa,
Y. Komatsu, O. Nakagawa, N. Hama, and H. Imura. Phenotype-related alteration in expression
of natriuretic peptide receptors in aortic smooth muscle cells. Circ. Res. 71: 34-39, 1992.

Y. Ogawa, K. Nakao, O. Nakagawa, Y. Komatsu, K. Hosoda, S. Suga, H. Arai, K. Nagata, N.
Yoshida, and H. Imura. Human C-type natriuretic peptide: characterization of the gene and
peptide. Hypertension 19: 809-813, 1992.

Y. Ogawa, K. Nakao, M. Mukoyama, K. Hosoda, G. Shirakami, H. Arai, Y. Saito, S. Suga, M.
Jougasaki, and H. Imura. Natriuretic peptides as cardiac hormones in normotensive and
spontaneously hypertensive rats: the ventricle is a major site of synthesis and secretion of brain
natriuretic peptide. Circ. Res. 69: 491-500, 1991.

M. Mukoyama, K. Nakao, K. Hosoda, S. Suga, Y. Saito, Y. Ogawa, G. Shirakami, M. Jougasaki,
K. Obata, H. Yasue, Y. Kambayashi, K. Inouye, and H. Imura. Brain natriuretic peptide (BNP) as
a novel cardiac hormone in humans: evidence for an exquisite dual natriuretic peptide system,
atrial natriuretic peptide and brain natriuretic peptide. J. Clin. Invest. 87: 1402-1412, 1991.

M. Mukoyama, K. Nakao, Y. Saito, Y. Ogawa, K. Hosoda, S. Suga, G. Shirakami, M. Jougasaki, and H. Imura. Increased human brain natriuretic peptide in congestive heart failure. N. Engl. J. Med. 323: 757-758, 1990.

M. Mukoyama, K. Nakao, Y. Saito, Y. Ogawa, K. Hosoda, S. Suga, G. Shirakami, M. Jougasaki,
and H. Imura. Human brain natriuretic peptide, a novel cardiac hormone. Lancet 335: 801-802,
1990.

Y. Ogawa, K. Nakao, M. Mukoyama, G. Shirakami, H. Itoh, K. Hosoda, Y. Saito, H. Arai, S.
Suga, M. Jougasaki, T. Yamada, Y. Kambayashi, K. Inoue, and H. Imura. Rat brain natriuretic
peptide: tissue distribution and molecular form. Endocrinology 126: 2225-2227, 1990.