Our Laboratories


About us

Our laboratory is a part of general internal medicine department including endocrinology, hepatology, pancreatology, and gastroenterology. Clinically, we provide medical treatments mainly for hematological malignancies such as leukemias, malignant lymphomas and multiple myeloma. We have been interested in the cases of malignant lymphoma of endocrine organs. Our research has focused on the diversity of intratumor clones in hematological malignancies, vascular endothelial function during hematopoietic stem cell transplantation, macrophage pore-forming protein Perforin-2, and exosomes in collagen and hematological diseases.

Selected publications

  • T. Narazaki, Y. Nakashima, Y. Tsukamoto, M. Tsuda, T. Masuda, D. Kimura, A. Takamatsu, K. Ohshima, M. Shiratsuchi, and Y. Ogawa. Transformation of follicular lymphoma to double-hit lymphoma during adjuvant chemotherapy for concurrent ovarian carcinoma.
    Int. J. Hematol. 142:253-256, 2019.
  • P. Xiong, M. Shiratsuchi, T. Matsushima, J. Liao, E. Tanaka, Y. Nakashima, R. Takayanagi, and Y. Ogawa. Regulation of expression and trafficking of perforin-2 by LPS and TNF-α.
    Cell Immunol. 320:1-10, 2017.
  • S. Haji, M. Shiratsuchi, T. Matsushima, A. Takamatsu, M. Tsuda, Y. Tsukamoto, E. Tanaka, H. Ohno, E. Fujioka, Y. Ishikawa, K. Imadome, and Ogawa. Achievement of disease control with donor-derived EB virus-specific cytotoxic T cells after allogeneic peripheral blood stem cell transplantation for aggressive NK-cell leukemia.
    Int. J. Hematol. 105:540-544, 2017.
  • Y. Nakashima, M. Shiratsuchi, I. Abe, Y. Matsuda, N. Miyata, H. Ohno, M. Ikeda, T. Matsushima, M. Nomura, and R. Takayanagi. Pituitary and adrenal involvement in diffuse large B-cell lymphoma, with recovery of their function after chemotherapy.
    BMC Endocr. Disord. 13:45, 2013.