研究室紹介
内分泌代謝・糖尿病研究室
原著論文
Kajitani Y, Miyazawa T, Inoue T, Kajitani N, Fujita M, Takeichi Y, Miyachi Y, Sakamoto R, Ogawa Y. High frequency of germline recombination in Nestin-Cretransgenic mice crossed with Glucagon-like peptide 1 receptor floxed mice.
PLoS One. 2023 Dec 20;18(12):e0296006. doi: 10.1371/journal.pone.0296006. eCollection
Nakamura S, Miyachi Y, Shinjo A, Yokomizo H, Takahashi M, Nakatani K, Izumi Y, Otsuka H, Sato N, Sakamoto R, Miyazawa T, Bamba T, Ogawa Y. Improved endurance capacity of diabetic mice during SGLT2 inhibition: potential role of AICARP,an endogenous AMPK activor in the soleus muscle. J Cachexia Sarcopenia Muscle. 2023 Dec;14(6):2866-2881. doi: 10.1002/jcsm.13350. Epub 2023 Nov8.PMID:37941098
Fujita M, Miyazawa T, Uchida K, Uchida N, Haji S, Yano S, Iwahashi N, Hatayama T, Katsuhara S, Nakamura S, Takeichi Y, Yokomoto-Umakoshi M, Miyachi Y, Sakamoto R, Iwakura Y, Ogawa Y. Dectin-2 Deficiency Promotes Pro-inflammatory Cytokine Release from Macrophages and Impairs Insulin Secretion. Endocrinology. 2023 Dec 1:bqad181. doi: 10.1210/endocr/bqad181. Online ahead of print.PMID: 38038367
Nakao H, Yokomoto-Umakoshi M, Nakatani K, Umakoshi H, Ogata M, Fukumoto T, Kaneko H, Iwahashi N, Fujita M, Ogasawara T, Matsuda Y, Sakamoto R, Izumi Y, Bamba T, Ogawa Y. Adrenal steroid metabolites and bone status in patients with adrenal incidentalomas and hypercortisolism. EBioMedicine. 2023 Jul 21:104733. doi: 10.1016/j.ebiom.2023.104733. Online ahead of print.PMID: 37543511
Kaneko H, Umakoshi H, Fukumoto T, Wada N, Ichijo T, Sakamoto S, Watanabe T, Ishihara Y, Tagami T, Ogata M, Iwahashi N, Yokomoto-Umakoshi M, Matsuda Y, Sakamoto R, Ogawa Y. Do multiple types of confirmatory tests improve performance in predicting subtypes of primary aldosteronism? Clin Endocrinol (Oxf). 2023 Apr;98(4):473-480. doi: 10.1111/cen.14854. Epub 2022 Dec 1.PMID: 36415024 Clinical Trial.
Ogasawara T, Fujii Y, Kakiuchi N, Shiozawa Y, Sakamoto R, Ogawa Y, Ootani K, Ito E, Tanaka T, Watanabe K, Yoshida Y, Kimura N, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Ogawa S. Genetic analysis of pheochromocytoma and paraganglioma complicating cyanotic congenital heart disease. J Clin Endocrinol Metab. 2022;107(9):2545-2555
Otsuka H, Yokomizo H, muscles from nondiabetic mice.Biochem J. Nakamura S, Izumi Y, Takahashi M, Obara S, Nakao M, Ikeda Y, Sato N, Sakamoto R, Miyachi Y, Miyazawa T, Bamba T, Ogawa Y.2022 Feb 11;479(3):425-444. Differential effect of canagliflozin, a sodium-glucosecotransporter 2(SGLT2) inhibitor, on slow and fast skeletal
Iwahashi N, Umakoshi H, Ogata M, Fukumoto T, Kaneko H, Terada E, Katsuhara S, Uchida N, Sasaki K, Yokomoto-Umakoshi M, Matsuda Y, Sakamoto R, Ogawa Y. Front Endocrinol(Whole Transcriptome Profiling of Adrenocortical Tumors Lausanne). Using Formalin-Fixed Paraffin-Embedded Samples. 2022 Feb 3;13:808331.
Abe K, Maeda Y, Matsuzaki C, Yokomizo H, Inoue T, Sonoda N, Ogawa Y, Inoguchi T.
2021 Nov;12(11):2028-2035. J Diabetes Investig. Bilirubin is inversely related to diabeteic peripheral neuropathy assessed by sural nerve conduction study.
Miyachi Y, Miyazawa T, Ogawa Y. Int J Mol Sci. 2022 Mar 16; 23(6):3222. HNF1A Mutations and Beta Cell Dysfunction in Diabetes.
Kaneko H, Umakoshi H, Ogata M, Wada N, Ichijo T, Sakamoto S, Watanabe T, Ishihara Y, Tagami T, Iwahashi N, Fukumoto T, Terada E, Katsuhara S, Yokomoto-Umakoshi M, Matsuda Y, Sakamoto R, Ogawa Y. Sci Rep. Machine learning-based models for predicting clinical outcomes after surgery in unilateral primary aldosteronism2022 Apr 6;12(1):5781. doi: 10.1038/s41598-022-09706-8.PMID: 35388079
Yano C, Yokomoto-Umakoshi M, Fujita M, Umakoshi H, Yano S, Iwahashi N, Katsuhara S, Kaneko H, Ogata M, Fukumoto T, Terada E, Matsuda Y, Sakamoto R, Ogawa Y. Bone Rep.
Coexistence of bone and vascular disturbances in patients with endogenous glucocorticoid excess. 2022 Aug 11;17:101610. doi: 10.1016/j.bonr.2022.101610. eCollection 2022 Dec.PMID: 36035657
Iwahashi N, Umakoshi H, Seki T, Gomez-Sanchez CE, Mukai K, Suematsu M, Umezawa Y, Oya M, Kosaka T, Seki M, Suzuki Y, Horiuchi Y, Ogawa Y, Nishimoto K. Characterization of Aldosterone-producing Cell Cluster (APCC) at Single-cell Resolution. J Clin Endocrinol Metab. 2022 Aug 18;107(9):2439-2448. doi: 10.1210/clinem/dgac394.PMID: 35796577 Free PMC article.
Yano S, Ishiuchi T, Abe S, Namekawa SH, Huang G, Ogawa Y, Sasaki H.2022 Aug 3;13(1):4440. doi: 10.1038/s41467-022-32141-2.PMID: 35922445 Free PMC article. Nat Commun. Histone H3K36me2 and H3K36me3 form a chromatin platform essential for DNMT3A-dependent DNA methylation in mouse oocytes.
Katsuhara S, Yokomoto-Umakoshi M, Umakoshi H, Matsuda Y, Iwahashi N, Kaneko H, Ogata M, Fukumoto T, Terada E, Sakamoto R, Ogawa Y. Impact of Cortisol on Reduction in Muscle Strength and Mass: A Mendelian Randomization Study J Clin Endocrinol Metab. 2021 Nov 28:dgab862. doi: 10.1210/clinem/dgab862. Online ahead of print.PMID: 34850018
Sakaguchi C, Tsuji K, Shioji K, Okamura K, Tsujimoto A, Nakamura I, Shirakawa H, Furukawa M, Ueno M, Morizane C, Furuse J. Risk stratification and prognostic factors in patients with unresectable undifferentiated carcinoma of the pancreas. Pancreatology. 2021 Jun;21(4):738-745. doi: 10.1016/j.pan.2021.02.008. Epub 2021 Feb 14.PMID: 33602645
Sagara R, Inoue T, Sonoda N, Yano C, Motoya M, Umakoshi H, Sakamoto R, Ogawa Y. Association between cortisol and left ventricular diastolic dysfunction in patients with diabetes mellitus J Diabetes Investig. 2021 Aug 31. doi: 10.1111/jdi.13653. Online ahead of print.PMID: 34465012
Takeichi Y, Miyazawa T, Sakamoto S, Hanada Y, Wang L, Gotoh K, Uchida K, Katsuhara S, Sakamoto R, Ishihara T, Masuda K, Ishihara N, Nomura M, Ogawa Y. Non-alcoholic fatty liver disease in mice with hepatocyte-specific deletion of mitochondrial fission factor. Diabetologia. 2021 May 29. doi: 10.1007/s00125-021-05488-2. Online ahead of print.
Yokomoto-Umakoshi M, Umakoshi H, Iwahashi N, Matsuda Y, Kaneko H, Ogata M, Fukumoto T, Terada E, Nakano Y, Sakamoto R, Ogawa Y.Protective Role of DHEAS in Age-related Changes in Bone Mass and Fracture Risk. J Clin Endocrinol Metab. 2021 Jun 22:dgab459. doi: 10.1210/clinem/dgab459. Online ahead of print.PMID: 34415029
Oda S, Ashida K, Uchiyama M, Sakamoto S, Hasuzawa N, Nagayama A, Wang L, Nagata H, Sakamoto R, Kishimoto J, Todaka K, Ogawa Y, Nakanishi Y, Nomura M. An open-label phase / a clinical trial of 11β-HSD1 inhibitor for Cushing's syndrome and autonomous cortisol secretion. J Clin Endocrinol Metab. 2021 Jun 18:dgab450. doi: 10.1210/clinem/dgab450. Online ahead of print.PMID: 34143883Ⅱ
Kaneko H, Umakoshi H, Ogata M, Wada N, Iwahashi N, Fukumoto T, Yokomoto-Umakoshi M, Nakano Y, Matsuda Y, Miyazawa T, Sakamoto R, Ogawa Y. Machine learning based models for prediction of subtype diagnosis of primary aldosteronism using blood test. Sci Rep. 2021 May 4;11(1):9140. doi: 10.1038
Fukumoto T, Umakoshi H, Ogata M, Yokomoto-Umakoshi M, Matsuda Y, Motoya M, Nagata H, Nakano Y, Iwahashi N, Kaneko H, Wada N, Miyazawa T, Sakamoto R, Ogawa Y. Significance of Discordant Results Between Confirmatory Tests in Diagnosis of Primary Aldosteronism. J Clin Endocrinol Metab. 2021 Jan 23;106(2):e866-e874. doi: 10.1210/clinem/dgaa812.PMID: 33165595
Nagata H, Lyu J, Imachi H, Fukunaga K, Sato S, Kobayashi T, Saheki T, Seo K, Salimah JB, Iwama H, Sakamoto R, Ogawa Y, Murao K. AGEs inhibit scavenger receptor class B type I gene expression via Smad1 in HUVECs. J Mol Endocrinol. 2021 Mar;66(3):223-231. doi: 10.1530/JME-20-0177.PMID: 33638940
Yokomoto-Umakoshi M, Umakoshi H, Miyazawa T, Ogata M, Sakamoto R, Ogawa Y. Investigating the causal effect of fibroblast growth factor 23 on osteoporosis and cardiometabolic disorders: A Mendelian randomization study. Bone.2021Feb;143:115777. doi:
Yokomoto-Umakoshi M,Umakoshi H, Sakamoto R , Fukumoto T, Ogata M, Nakano Y, Iwahashi N, Kaneko H, Mizoguchi N, Hattori A, Miyazawa T, Matsuda Y, Kawate H, Ogawa Y; Q-AND-A study group. Role of deteriorated bone quality in the development of osteoporosis in pheochromocytoma and paraganglioma. Bone. 2021 Jan;142:115607.
Umakoshi H, Sakamoto R, Matsuda Y, Yokomoto-Umakoshi M, Nagata H, Fukumoto T, Ogata M, Ogawa Y, Q-AND-A study group. Role of Aldosterone and Potassium Levels in Sparing Confirmatory Tests in Primary Aldosteronism. J Clin Endocrinol Metab. 2020 Apr;105(4):1284-1289
Yokomoto-Umakoshi M, Umakoshi H, Fukumoto T, Matsuda Y, Nagata H, Ogata M, Kawate H, Miyazawa T, Sakamoto R, Ogawa Y; Q-AND-A study group. Pheochromocytoma and paraganglioma: An emerging cause of secondary osteoporosis. Bone. 2020 Apr; 133: 115221.
Narazaki T, Shiratsuchi M, Matsushima T, Tsuda M, Tsukamoto Y, Muta H, Masuda T, Kimura D, Takamatsu A, Yamamoto H, Oda Y, Miyoshi H, Ohshima K, Matsuda Y, Sakamoto R, Nakashima Y, Ogawa Y. Clinico-pathological characteristics of primary adrenal lymphomas – potential efficacy of autologous stem cell transplantation. Leuk Lymphoma. 2020 Jun; 61(6)1516-1518.
Yokomoto-Umakoshi M, Umakoshi H, Ogata M, Fukumoto T, Matsuda Y, Miyazawa T, Sakamoto R, Ogawa Y; Q-AND-A study group. Coexistence of Osteoporosis and Atherosclerosis in Pheochromocytoma: New Insights into its Long-term Management. Osteoporosis Int. 2020 Nov ;31(11):2151-2160.
Takeno A, Kanazawa I, Tanaka KI, Notsu M, Kanasaki K, Oono T, Ogawa Y, Sugimoto T. High glucose promotes mineralization via bone morphogenetic protein 4-Smad signals in early stage of osteoblast differentiation. Diabetol Int. 2020 Aug;10.1007/s13340-020-00463-5
Ogata M, Umakoshi H, Fukumoto T, Matsuda Y, Yokomoto-Umakoshi M, Nagata H, Wada N, Miyazawa T, Sakamoto R, Ogawa Y; Q-AND-A Study Group. Significance of aldosterone gradient within left adrenal vein in diagnosing unilateral subtype of primary aldosteronism. Clin Endocrinol (Oxf). 2021 Jan;94(1):24-33. doi: 10.1111/cen.14320. Epub 2020 Sep 19.PMID: 32854164
Hanada Y, Ishihara N, Wang L, Otera H, Ishihara T, Koshiba T, Mihara K, Ogawa Y, Nomura M. MAVS is energized by Mff which senses mitochondrial metabolism via AMPK for acute antiviral immunity Nat Commun. 2020 Nov 11;11(1):5711. doi: 10.1038/s41467-020-19287-7.PMID: 33177519
Kaneko H, Umakoshi H, Ishihara Y ,Sugawa T, Nanba K, Tsuiki M, Kusakabe T, Satoh-Asahara N, Yasoda A, Tagami T. Reassessment of urinary aldosterone measurement after saline infusion in primary aldosteronism. Journal of Endocr Soc. 2020 Jul;4(9):bvaa100.
Yano S, Ashida K, Sakamoto R, Sakaguchi C, Ogata M, Maruyama K, Sakamoto S, Ikeda M, Ohe K, Akasu S, Iwata S, Wada N, Matsuda Y, Nakanishi Y, Nomura M, Ogawa Y. Human leucocyte antigen DR15, a possible predictive marker for immune checkpoint inhibitor-induced secondary adrenal insufficiency. Eur J Cancer. 2020 May;130:198-203.
Y. Ikeda, N. Sonoda, B. Bachuluun, S. Kimura, Y. Ogawa, and T. Inoguchi. Aberrant activation of bone marrow Ly6C high monocytes in diabetic mice contributes to impaired glucose tolerance. PLoS One. 25;15(2) 2020 Feb
Yokomoto-Umakoshi M*, Sakamoto R*, Umakoshi H, Matsuda Y, Nagata H, Fukumoto T, Ogata M, Ogawa Y; Q-AND-A study group.(* equally contributed)Unilateral Primary Aldosteronism as an Independent Risk Factor for Vertebral Fracture. Clin Endocrinol(Oxf). doi: 10.1111/cen.14145.
2019 Dec
Umakoshi H, Sakamoto R, Matsuda Y, Yokomoto-Umakoshi M, Nagata H, Fukumoto T, Ogata M, Ogawa Y, Q-AND-A study group.Role of Aldosterone and Potassium Levels in Sparing Confirmatory Tests in Primary Aldosteronism. J Clin Endocrinol Metab. pii:dgz148. doi:10.1210/clinem/ dgz148.
2019, Oct
Takei R, Inoue T, Sonoda N, Kohjima M, Okamoto M, Sakamoto R, Inoguchi T, Ogawa Y. Bilirubin reduces visceral obesity and insulin resistance by suppression of inflammatory cytokines. PLoS One. 2019 Oct 2;14(10):e0223302.
Y. Kodama, F. Hyodo, M. Yamato, K. Yasukawa, Y. Minami, N. Sonoda, Y. Ogawa, K. Ichikawa, and T. Inoguchi. Dynamic nuclear polarization magnetic resonance imaging and the oxygen-sensitive paramagnetic agent OX63 provide a noninvasive quantitative evaluation of kidney .Kidney International. 2019 Sep;96(3):787-792.
Y. Inoguchi, K. Ichiyanagi, H. Ohishi, Y. Maeda, N. Sonoda, Y. Ogawa, T. Inoguchi, and H. Sasaki.Poorly controlled diabetes during pregnancy and lactation activates the Foxo1 pathway and causes glucose intolerance in adult offspring. Scientific Report. 2019 Jul ;9(1):10181.
K. Uchida, M.Nomura, T. Yamamoto, Y. Ogawa, N, Teramoto. Rab8a is involved in membrane trafficking of Kir6.2 in the MIN6 insulinoma cell line Pflugers Arch471(6):877-887. doi: 10.1007/s00424-018-02252-1. Epub 2019 .
T. Maki, S. Maeno, Y. Maeda, M. Yamato, N. Sonoda, Y. Ogawa. M. Wakisaka, and T. Inoguchi. Amelioration of diabetic nephropathy by SGLT2 inhibitors independent of its glucose-lowering effect: A possible role of SGLT2 in mesangial cells.
Sci. Rep. 9(1): 4703, 2019.
Y. Minami, N. Sonoda, E. Hayashida, H. Makimura, M. Ide, N. Ikeda, M. Ohgidani, TA. Kato, Y. Seki, Y. Maeda, S. Kanba, R. Takayanagi, Y. Ogawa, and T. Inoguchi. P66Shc Signaling Mediates Diabetes-Related Cognitive Decline.
Sci. Rep. 8(1): 3213, 2018.
S. Yano, K Ashida, H. Nagata, K. Ohe, N. Wada, Y. Takeichi, Y. Hanada, Y. Ibayashi, L. Wang, S. Sakamoto, R. Sakamoto, H. Uchi, M. Siratsuchi, M. Furue, M. Nomura, Y. Ogawa. Nivolmab-induced thyroid dysfunction lacking antithyroid is frequently evolked in Japanese patients with malignant melanoma.
BMC Endocr Disord. 8;18(1): 36, 2018.
C. Iwaya, H. Kitajima, K. Yamamoto, Y. Maeda, N. Sonoda, H. Shibata, and T. Inoguchi. DNA methylation of the Kif14 gene region on whole blood provide prediction for the chronic inflammation at the adipose tissue.
Biochem. Biophys. Res. Commun. 497(3): 908-915, 2018.
T. Inoue, N. Sonoda, S. Hiramatsu, S. Kimura, Y. Ogawa, and T. Inoguchi. Serum Bilirubin Concentration is Associated with Left Ventricular Remodeling in Patients with Type 2 Diabetes Mellitus: A Cohort Study.
Diabetes Ther. 9(1): 331-338, 2018.
C. Inoue, C. Zhao, Y. Tsuduki, M. Udono, L. Wang,M. Nomura, and Y. Katakura. SMARCD1 regulates senescence-associated lipid accumulation in hepatocytes. NPJ Aging Mech Dis. 30; 3:11. doi: 10.1038/s41514-017-0011-1, 2017
T. Yoshikawa, T. Kishi, K. Shinohara, K. Takesue, R. Shibata. N. Sonoda, T. Inoguchi, K. Sunagawa, H. Tsutsui, and Y. Hirooka. Arterial pressure lability is improved by sodium-glucose cotransporter 2 inhibitor in streptozotocin-induced diabetic rats.
Hypertens. Res. 40(7): 646-651, 2017
T. Maki, Y. Maeda, N. Sonoda, H. Makimura, S. Kimura, S. Maeno, R. Takayanagi and T. Inoguchi. Renoprotective effect of a novel selective PPAR modulator K-877 in db/db mice: A role of diacylglycerol-protein kinase C-NAD(P)H oxidase pathway.
Metabolism 71: 33-45, 2017.
A. Ikawa-Yoshida, T. Matsumoto, S. Okano, Y. Aoyagi, Y. Matsubara, T. Furuyama, Y. Nakatsu, T. Tsuzuki, M. Onimaru, T. Ohkusa, M. Nomura, Y. Maehara: BubR1 insufficiency impairs liver regeneration in aged mice after hepatectomy through intercalated disc abnormality.
Sci Rep 6: 32399, 2016
Y. Matsuda, H. Kawate, T. Watanabe, C. Matsuzaki, R. Sakamoto, K. Shibue, K. Ohnaka, K. Anzai, M. Nomura, R. Takayanagi: Eplerenone improves carotid intima-media thickness (IMT) in patients with primary Aldosteronism.
Endocrine J 63: 249-255, 2016
H. Nakagomi, M. Yoshiyama, T. Mochizuki, T. Miyamoto, R. Komatsu, Y. Imura, Y. Morizawa, M. Hiasa, T. Miyaji, S. Kira, I. Araki, K. Fujishita, K. Shibata, E. Shigetomi, Y. Shinozaki, R. Ichikawa, H. Uneyama, K. Iwatsuki, M. Nomura, WC. de Groat , Y. Moriyama, M. Takeda, S. Koizumi: Urothelial ATP exocytosis: regulation of bladder compliance in the urine storage phase.
Sci Rep 6: 29761, 2016
T. Tando, A. Hirayama, M. Furukawa, Y. Sato, T. Kobayashi, A. Funayama, A. Kanaji, W. Hao, R. Watanabe, M. Morita, T. Oike, K. Miyamoto, T. Soga, M. Nomura, A. Yoshimura, M. Tomita, M. Matsumoto, M. Nakamura, Y. Toyama, T. Miyamoto: Smad2/3 proteins are required for immobilization-induced skeletal muscle atrophy.
J BiolChem 291: 12184-94, 2016
T. Yanase, T. Tajima, T. Katabami, Y. Iwasaki, Y. Tanahashi, A. Sugawara, T. Hasegawa, T. Mune, Y. Oki, Y. Nakagawa, N. Miyamura, C. Shimizu, M. Otsuki, M. Nomura, Y. Akehi, M. Tanabe, S. Kasayama: Diagnosis and treatment of adrenal insufficiency including adrenal crisis: a Japan Endocrine Society clinical practice guideline.
Endocr 63: 765-784, 2016
T. Inoguchi, N. Sonoda, and Y. Maeda. Bilirubin as an important physiological modulator of oxidative stress and chronic inflammation in metabolic syndrome and diabetes: a new aspect on old molecule.
Diabetol. Int. 7: 338–341, 2016.
T. Inoue, Y. Maeda, N. Sonoda, S. Sasaki, T. Kabemura, K. Kobayashi, and T. Inoguchi. Hyperinsulinemia and sulfonylurea use are independently associated with left ventricular diastolic dysfunction in patients with type 2 diabetes mellitus with suboptimal blood glucose control.
BMJ Open Diabetes Res. Care. 4: e000223, 2016.
S. Kimura, T. Inoguchi, T. Yamasaki, M. Yamato, M. Ide, N. Sonoda, K. Yamada, and R. Takayanagi. A novel DPP-4 inhibitor teneligliptin scavenges hydroxyl radicals: In vitro study evaluated by electron spin resonance spectroscopy and in vivo study using DPP-4 deficient rats.
Metabolism 65: 138-145, 2016.
T. Watanabe, K. Ashida, K. Goto, H. Nawata, R. Takayanagi, T. Yanase, M. Nomura: Dehydroepiandrosterone-enhanced dual specificity protein phosphatase (DDSP) prevents diet-induced and genetic obesity.
Biochem Biophys Res Commun 468: 196-201, 2015
L. Wang, M. Nomura: Loss of Drp1 in the liver leads to an alteration in expression of the genes involved in the immune system.
Genomic Data 6: 27-30, 2015
P. Enciso, L. Wang, Y. Kawahara, S. Sakamoto, S. Shimada, Y. Takeichi, R. Takayanagi, M. Nomura: Dietary vitamin D3 improves postprandial hyperglycemia in aged mice.
Biochem Biophys Res Commun 461: 165-171, 2015
T. Ishihara, R. Ban-Ishihara, M. Maeda, Y. Matsunaga, A. Ichimura, S. Kyogoku, H. Aoki, S. Katada, K. Nakada, M. Nomura, N. Mizushima, K. Mihara, N. Ishihara: Dynamics of mitochondrial DNA nucleoids regulated by mitochondrial fission is essential for maintenance of homogeneously active mitochondria during neonatal heart development.
Mol Cell Biol 35: 211-223, 2015
T. Inoue, T. Inoguchi, N. Sonoda, H. Hendarto, H. Makimura, S. Sasaki, H. Yokomizo, Y. Fujimura, D. Miura, and R. Takayanagi. GLP-1 analog liraglutide protects against cardiac steatosis, oxidative stress and apoptosis in streptozotocin-induced diabetic rats.
Atherosclerosis 240: 250-259, 2015.
S. Sakamoto, T. Miyaji, M. Hiasa, R. Ichikawa, A. Uematsu, K. Iwatsuki, A. Shibata, H. Uneyama, R. Takayanagi, A. Yamamoto, H. Omote, M. Nomura, Y. Moriyama:
Impairment of vesicular ATP release affects glucose metabolism and increases insulin sensitivity.
Sci Rep 4: 6689, 2014
O. Udagawa, T. Ishihara, M. Maeda, Y. Matsunaga, S. Tsukamoto, N. Kawano, K. Miyado, H. Shitara, S. Yokota, M. Nomura, K. Mihara, N. Mizushima, N. Ishihara:
Mitochondrial fission factor Drp1maintains oocyte quality via dynamic rearrangement of multiple organelles.
Curr Biol 24: 2451-2458, 2014
H. Kawate, M. Kohno, Y. Matsuda, Y. Akehi, M. Tanabe, T. Horiuchi, K. Ohnaka, M. Nomura, T. Yanase, R. Takayanagi: Long term study of subclinical Cushing’s syndrome shows high prevalence of extra-adrenal malignancy in patients with functioning bilateral adrenal tumors.
Endocrine J 61: 1205-1212, 2014.
Y. Shinozaki, M. Nomura, K. Iwatsuki, Y. Moriyama, C. Gachet, S. Koizumi: Microglia triggers astrocyte-mediated neuroprotection via purinergic gliotransmission.
Sci Rep 4: 4329, 2014
M. Nomura, HL. Zhu, L. Wang, H. Morinaga, R. Takayanagi, N. Teramoto : SMAD2 disruption in mouse pancreatic beta cells leads to islet hyperplasia and impaired insulin secretion due to the attenuation of ATP-sensitive K+ channel activity.
Diabetologia 57: 157-166, 2014
Y. Maeda, T. Inoguchi, E. Etoh, Y. Kodama, S. Sasaki, N. Sonoda, H. Nawata, M. Shimabukuro, and R. Takayanagi.
Brachial-ankle pulse wave velocity predicts all-cause mortality and cardiovascular events in patients with diabetes: the Kyushu Prevention Study of Atherosclerosis.
Diabetes Care 37: 2383-90, 2014.
C. Natsuaki, T. Inoguchi, Y. Maeda, T. Yamada, S. Sasaki, N. Sonoda, M. Shimabukuro, H. Nawata, and R. Takayanagi.
Association of borderline ankle-brachial index with mortality and the incidence of peripheral artery disease in diabetic patients.
Atherosclerosis 234: 360-365, 2014.
H. Yokomizo, T. Inoguchi, N. Sonoda, Y. Sakaki, Y. Maeda, T. Inoue, E. Hirata, R. Takei, N. Ikeda, M. Fujii, K. Fukuda, H. Sasaki, R. Takayanagi.
Maternal high-fat diet induces insulin resistance and deterioration of pancreatic β-cell function in adult offspring with sex differences in mice.
Am. J. Physiol. Endocrinol Metab. 306: E1163-75, 2014.
B. Batchuluun, T. Inoguchi, N. Sonoda, S. Sasaki, T. Inoue, Y. Fujimura, D. Miura, and R. Takayanagi.
Metformin and liraglutide ameliorate high glucose-induced oxidative stress via inhibition of PKC-NAD(P)H oxidase pathway in human aortic endothelial cells.
Atherosclerosis 232: 156-164, 2014.
R. Sakamoto, E. Matsubara, M. Nomura, L. Wang, Y. Kawahara, T. Yanase, H. Nawata: Roles for corticotropin-releasing factor receptor type 1 in energy homeostasis in mice.
Metabolism 62: 1739-1748, 2013
Y. Akehi, H. Kawate, K. Murase, R. Nagaishi, T. Nomiyama, M. Nomura, R. Takayanagi, T Yanase : Proposed diagnostic criteria for subclinical Cushing's syndrome associated with adrenal incidentaloma.
Endocrine J 60: 903-912, 2013
K. Kuramoto, T Okamura, T Yamaguchi, Y. Nakamura, S. Wakabayashi, H. Morinaga, M. Nomura, T. Yanase, K. Otsu, N. Usuda, S. Matsumura, K. Inoue, T. Fushiki, Y. Kojima, T. Hashimoto, F. Sakai, F. Hirose, T. Osumi: Perilipin 5, a lipid droplet-binding protein, protects heart from oxidative burden by sequestering fatty acid from excessive oxidation.
J Biol Chem 287: 23852-23863, 2012
H. Hendarto, T. Inoguchi, Y. Maeda, N. Ikeda, J. Zheng, R. Takei, H. Yokomizo, E. Hirata, N. Sonoda, and R. Takayanagi.
GLP-1 analog liraglutide protects against oxidative stress and albuminuria in streptozotocin-induced diabetic rats via protein kinase A-mediated inhibition of renal NAD(P)H oxidases.
Metabolism 61: 1422-1434, 2012.
L. Wang, M. Nomura, Y. Goto, K. Tanaka, R. Sakamoto, I. Abe, S. Sakamoto, A. Shibata, PL. Enciso , M. Adachi, K. Ohnaka, H. Kawate, R. Takayanagi: Smad2 disruption in the central nervous system leads to aberrant cerebellar development and early postnatal ataxia in mice.
J Biol Chem 286: 18766-18774, 2011
GC. Chen, Y. Goto, R. Sakamoto, K. Tanaka, E. Matsubara, M. Nakamura, H. Zheng, J. Lu, R. Takayanagi, M. Nomura: GLI1, a crucial mediator of sonic hedgehog signaling in prostate cancer, functions as a negative modulator for androgen receptor.
Biochem Biophys Res Commun 404: 809-815, 2011
T. Inoue, K. Kobayashi, T. Inoguchi, N. Sonoda, M. Fujii, Y. Maeda, Y. Fujimura, D. Miura, K. Hirano, and R. Takayanagi.
Reduced expression of adipose triglyceride lipase enhances tumor necrosis factor α-induced intercellular adhesion molecule-1 expression in human aortic endothelial cells via protein kinase c-dependent activation of nuclear factor-κB.
J. Biol. Chem. 286: 32045-32053, 2011.
N. Ikeda, T. Inoguchi, N. Sonoda, M. Fujii, R. Takei, E. Hirata, H. Yokomizo, J. Zheng, Y. Maeda, K. Kobayashi, and R. Takayanagi.
Biliverdin protects against the deterioration of glucose tolerance in db/db mice.
Diabetologia 54: 2183-2191, 2011.
K. Iwatsuki, M. Nomura, A. Shibata, R. Ichikawa, L.M.P. Enciso, L. Wang, R. Takayanagi. K. Torii, H. Uneyama: Generation and characterization of T1R2-LacZ knock-in mouse.
Biochem Biophys Res Commun 402: 495-499, 2010
Y. Maeda, T. Inoguchi, R. Takei, F. Sawada, S. Sasaki, M. Fujii, K. Kobayashi, H. Urata, A. Nishiyama, and R. Takayanagi.
Inhibition of chymase protects against diabetes-induced oxidative stress and renal dysfunction in hamsters.
Am. J. Physiol. Renal Physiol. 299: F1328-1338, 2010.
M. Fujii, T. Inoguchi, S. Sasaki, Y. Maeda, J. Zheng, K. Kobayashi, and R. Takayanagi.
Bilirubin and biliverdin protect rodents against diabetic nephropathy by downregulating NAD(P)H oxidase.
Kidney Int. 78: 905-919, 2010.
Y. Matoba, T. Inoguchi, S. Suzuki, S. Nasu, T. Hashimoto, T. Yanase, H. Nawata, and R. Takayanagi.
Impact of metabolic syndrome on the progression of Intima-Media Thickening in Japanese--a follow-up study.
Diabetes Res. Clin. Pract. 86: e50-53, 2009.
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