研究室紹介

血液研究室

原著論文

Shojiro Haji, Taiki Ito, Carla Guenther, Miyako Nakano, Takashi Shimizu, Daiki Mori, Yasunori Chiba, Masato Tanaka, Sushil K Mishra, Janet A Willment, Gordon D Brown, Masamichi Nagae, Sho Yamasaki.
Human Dectin-1 is O-glycosylated and serves as a ligand for C-type lectin receptor CLEC-2.
elife. 2022. doi: 10.7554/eLife.83037
 
Shojiro Haji, Motoaki Shiratsuchi, Akiko Takamatsu, Mariko Tsuda, Hiroki Muta, Toru Masuda, Yasuhiro Nakashima, Yoshihiro Ogawa.
Endothelial function testing before conditioning therapy is useful for predicting transplant-related complications after allogeneic hematopoietic cell transplantation.
International journal of hematology. 2022. doi: 10.1007/s12185-022-03498-3
 
Masuda T, Haji S (equally contributed), Nakashima Y, Tsuda M, Kimura D, Takamatsu A, Iwahashi N, Umakoshi H, Shiratsuchi M, Kikutake C, Suyama M, Ohkawa Y, Ogawa Y.
Identification of a drug-response gene in multiple myeloma through longitudinal single-cell transcriptome sequencing
iScience. 2022 Jul 19;25(8):104781. doi: 10.1016/j.isci.2022.104781. eCollection 2022 Aug 19.
 
Tsuda M, Hirata A, Tokunaga S, Masuda T, Haji S, Kimura D, Nojiri C, Nakashima Y, Shiratsuchi M, Kato K, Miyamoto T, Akashi K, Nakashima N, Ogawa Y.
Rapid decrease in eGFR with concomitant use of tyrosine kinase inhibitors and renin-aldosterone-angiotensin system inhibitors in patients with chronic myelogenous leukemia
Int J Hematol. 2022 Aug 6. doi: 10.1007/s12185-022-03433-6. Online ahead of print.
 
Takamatsu A, Nakashima Y, Haji S, Tsuda M, Masuda T, Kimura D, Shitatsuchi M, Ogawa Y.
Circulating endothelial cells and endothelial progenitor cells as potential predictors of acute GVHD after allogeneic hematopoietic stem cell transplantation.
Eur J Haematol. 2022 Aug;109(2):146-153. doi: 10.1111/ejh.13781. Epub 2022 May 4.
 
Nagata M, Toyonaga K, Ishikawa E, Haji S, Okahashi N, Takahashi M, Izumi Y, Imamura A, Takato K, Ishida H, Nagai S, Illarionov P, Stocker B, Timmer MS, Smith DGM, Williams SJ, Bamba T, Miyamoto T, Arita M, Appelmelk BJ, Yamasaki S. 
Helicobacter metabolites exacerbate gastritis through C-type lectin receptors.
J Exp Med. 2021 Jan 4;218(1):e20200815. doi: 10.1084/jem.20200815.
 
Narazaki T, Shiratsuchi M, Matsushima T, Tsuda M, Tsukamoto Y, Muta H, Masuda T, Kimura D, Takamatsu A, Yamamoto H, Oda Y, Miyoshi H, Ohshima K, Matsuda Y, Sakamoto R, Nakashima Y, Ogawa Y.
Clinico-pathological characteristics of primary adrenal lymphomas – potential efficacy of autologous stem cell transplantation.
Leukemia & Lymphoma. 2020 Jun;61(6):1516-1518. doi: 10.1080/10428194.2020.1725507.
 
Narazaki T, Nakashima Y, Tsukamoto Y, Nishida R, Tsuda M, Muta H, Kimura D, Masuda T, Takamatsu A, Kohashi K, Murakami D, Shiratsuchi M, Ogawa Y.
Schizophyllum commune sinusitis after allogeneic bone marrow transplantation for myelodysplastic syndrome: A case report and literature review.
Transpl Infect Dis. 2020 Feb;22(1):e13205.
 
Narazaki T, Shiratsuchi M, Tsuda M, Tsukamoto Y, Muta H, Masuda T, Kimura D, Takamatsu A, Nakanishi R, Oki E, Fujiwara M, Oda Y, Nakashima Y, Ogawa Y. 
Intestinal Behçet's Disease with Primary Myelofibrosis Involving Trisomy 8.
Acta Haematol. 2019 Jul 10:1-4.
 
Narazaki T, Nakashima Y, Tsukamoto Y, Tsuda M, Masuda T, Kimura D, Takamatsu A, Ohshima K, Shiratsuchi M, Ogawa Y.
Transformation of follicular lymphoma to double-hit lymphoma during adjuvant chemotherapy for concurrent ovarian carcinoma.
Int J Hematol. 2019 Sep;110(3):375-380.
 
Narazaki T, Haji S, Nakashima Y, Tsukamoto Y, Tsuda M, Takamatsu A, Ohno H, Matsushima T, Matsumoto T, Nogami K, Shima M, Shiratsuchi M, Ogawa Y.
Acquired hemophilia A associated with autoimmune pancreatitis with serum IgG4 elevation.
Int J Hematol. 2018 Sep;108(3):335-338.

 
Tsuda M, Shiratsuchi M, Nakashima Y, Ikeda M, Muta H, Narazaki T, Masuda T, Kimura D, Takamatsu A, Matsumoto M, Fujimura Y, Kokame K, Matsushima T and Ogawa Y.
Upshaw-Schulman syndrome diagnosed during pregnancy complicated by reversible cerebral vasoconstriction syndrome.
Transfus Apher Sci. 2018; 57: 790-792.

 
Xiong P, Shiratsuchi M, Matsushima T, Liao J, Tanaka E, Nakashima Y, Takayanagi R, Ogawa Y. Regulation of expression and trafficking of perforin-2 by LPS and TNF-α.
Cell Immunol. 2017 Oct;320:1-10.

 
Haji S, Shiratsuchi M, Matsushima T, Takamatsu A, Tsuda M, Tsukamoto Y, Tanaka E, Ohno H, Fujioka E, Ishikawa Y, Imadome K, Ogawa Y.
Achievement of disease control with donor-derived EB virus-specific cytotoxic T cells after allogeneic peripheral blood stem cell transplantation for aggressive NK-cell leukemia.
Int J Hematol. 105:540-544, 2017
 
Haji S, Kiyasu J, Choi I, Suehiro Y, Toyoda K, Tsuda M, Takamatsu A, Nakashima Y, Miyoshi H, Shiratsuchi M, Yamasaki S, Uike N, Abe Y.
Administration of an anti-CC chemokine receptor 4 monoclonal antibody, mogamulizumab, before allogeneic bone marrow transplantation for adult T-cell leukemia/lymphoma.
Bone Marrow Transplant. 51:432-434, 2015
 
McCormack RM, de Armas LR, Shiratsuchi M, Fiorentino DG, Olsson ML, Lichtenheld MG, Morales A, Lyapichev K, Gonzalez LE, Strbo N, Sukumar N, Stojadinovic O, Plano GV, Munson GP, Tomic-Canic M, Kirsner RS, Russell DG, Podack ER.
Perforin-2 is essential for intracellular defense of parenchymal cells and phagocytes against pathogenic bacteria.
elife 4:pii: e06508, 2015
 
Kiyasu J, Miyoshi H, Hirata A, Arakawa F, Ichikawa A, Niino D, Sugita Y, Yufu Y, Choi I, Abe Y, Uike N, Nagafuji K, Okamura T, Akashi K, Takayanagi R, Shiratsuchi M, Oshima K.
Expression of programmed cell death ligand 1 is associated with poor overall survival in patients with diffuse large B-cell lymphoma.
Blood. 126(19): 2193-2201, 2015
 
Tsuda M, Nakashima Y, Ikeda M, Shimada S, Nomura M, Matsushima T, Takahashi S, Aishima S, Oda Y, Shiratsuchi M, Takayanagi R.
Intravascular Large B-Cell Lymphoma Complicated by Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis that was Successfully Treated with Rituximab-Containing Chemotherapy.
J Clin Exp Hematop. 55(1): 39-43, 2015
 
Nakashima Y, Shiratsuchi M, Abe I, Matsuda Y, Miyata N, Ohno H, Ikeda M, Matsushima T, Nomura M, Takayanagi R.
Pituitary and adrenal involvement in diffuse large B-cell lymphoma, with recovery of their function after chemotherapy.
BMC Endocr Disord. 13: 45, 2013 
 
Sada E, Abe Y, Ohba R, Tachikawa Y, Nagasawa E, Shiratsuchi M, Takayanagi R.
Vitamin K2 modulates differentiation and apoptosis of bith myeloid and erythroid lineages.
Eur J Haematol. 85: 538-548, 2010 
 
Ohtsuka R, Abe Y, Sada E, Kiyasu J, Ashikari A, Shiratsuchi M, Nishimura J, Takayanagi R, Ohshima K.
Adult patient with Epstein-Barr virus (EBV)-associated lymphoproliferative disorder: chronic active EBV infection or de novo extranodal natural killer (NK)/T-cell lymphoma, nasal type?
Intern Med. 48: 471-474, 2009 
 
Abe Y, Ito T, Baba E, Nagafuji K, Kawabe K, Choi I, Arita Y, Miyamoto T, Teshima T, Nakano S, Harada M.
Nonmyeloablative allogeneic hematopoietic stem cell transplantation as immunotherapy for pancreatic cancer.
Pancreas. 38: 815-819, 2009 
 
Miyashita K, Fujii K, Yamada Y, Hattori H, Taguchi K, Yamanaka T, Yoshida MA, Okamura J, Oda S, Muta K, Nawata H, Takayanagi R, Uike N.
Frequent microsatellite instability in non-Hodgkin lymphomas irresponsive to chemotherapy.
Leukemia Research. 32: 1183-1195, 2008 
 
Sarakul O, Vattanaviboon P, Wilairat P, Fucharoen S, Abe Y, Muta K.
Inhibition of alpha-globin gene expression by RNAi.
Biochem Biophys Res Commun. 369: 935-938, 2008 
 
Masaki S, Ohtsuka R, Abe Y, Muta K, Umemura T.
Expression patterns of microRNAs 155 and 451 during normal human erythropoiesis.
Biochem Biophys Res Commun. 364: 509-514, 2007 
 
Ohtsuka R, Abe Y, Fujii T, Yamamoto M, Nishimura J, Takayanagi R, Muta K.
Mortalin is a novel mediator of erythropoietin signaling.
Eur J Haematol. 79: 114-125, 2007 
 
Tachikawa Y, Matsushima T, Abe Y, Sakano S, Yamamoto M, Nishimura J, Nawata H, Takayanagi R, Muta K.
Pivotal role of Notch signaling in regulation of erythroid maturation and proliferation.
Eur J Haematol. 77: 273-281, 2006 
 
Nakashima Y, Tagawa H, Suzuki R, Karnan S, Karube K, Ohshima K, Muta K, Nawata H, Morishima Y, Nakamura S, Seto M.
Genome-wide array-based comparative genomic hybridization of natural killer cell lymphoma/leukemia: different genomic alteration patterns of aggressive NK-cell leukemia and extranodal Nk/T-cell lymphoma, nasal type.
Genes Chromosomes Cancer. 44: 247-255, 2005 
 
Nagasawa E, Abe Y, Nishimura J, Yanase T, Nawata H, Muta K.
Pivotal role of peroxisome proliferator-activated receptor gamma (PPARγ) in regulation of erythroid progenitor cell proliferation and differentiation.
Exp Hematol. 33: 857-864, 2005 
 
Sae-Ung N, Matsushima T, Choi I, Abe Y, Winichagoon P, Fucharoen S, Nawata H, Muta K.
Role of NF-κB in regulation of apoptosis of erythroid progenitor cells.
Eur J Haematol. 74: 315-323, 2005 
 
Zhang M, Abe Y, Matsushima T, Nishimura J, Nawata H, Muta K.
Selective cyclooxygenase 2 inhibitor NS-398 induces apoptosis in myeloma cells via a Bcl-2 independent pathway.
Leuk Lymphoma. 46: 425-433, 2005 
 
Muta K, Ohshima K, Abe Y, Uike N, Choi I, Matsushima T, Nishimura J, Kikuchi M, Nakashima M, Watanabe T, Nawata H.
Expression of human tumor-associated antigen RCAS1 in adult T-cell leukemia/lymphoma.
Int J Hematol. 79: 340-344, 2004 
 
Shiokawa S, Matsushima T, Choi I, Abe Y, Shiratsuchi M, Suehiro Y, Muta K, Ohshima K, Nishimura J.
Re-entry of tumor B cells into the cycle of somatic mutation and isotype switching in follicular lymphoma.
Br J Haematol. 120: 492-495, 2003 
 
Abe Y, Ohshima K, Nakashima M, Hara K, Matsushima T, Choi I, Nishimura J, Kikuchi M, Nawata H, Watanabe T, Muta K.
Expression of apoptosis-associated protein RCAS1 in macrophages of histiocytic necrotizing lymphadenitis.
Int J Hematol. 77: 359-363, 2003 
 
Minami R, Muta K, Umemura T, Motomura S, Abe Y, Nishimura J, Nawata H.
p16(INK4a) induces differentiation and apoptosis in erythroid lineage cells.
Exp Hematol. 31: 355-362, 2003 
 
Abe Y, Choi I, Matsushima T, Nishimura J, Inaba S, Nawata H, Muta K.
Hemophagocytic syndrome: a rare complication of allogeneic nonmyeloablative hematopoietic stem cell transplantation.
Bone Marrow Transplant. 29: 799-801, 2002 
 
Shiratsuchi M, Muta K, Abe Y, Motomura S, Taguchi F, Takatsuki H, Uike N, Umemura T, Nawata H, Nishimura J.
Clinical significance of telomerase activity in multiple myeloma.
Cancer. 94: 2232-2238, 2002 
 
Matsushima T, Nakashima M, Oshima K, Abe Y, Nishimura J, Nawata H, Watanabe T, Muta K.
Receptor binding cancer antigen expressed on SiSo cells, a novel regulator of apoptosis of erythroid progenitor cells.
Blood. 98: 313-321, 2001 
 
Choi I, Muta K, Wickrema A, Krantz SB, Nishimura J, Nawata H.
Interferon gamma delays apoptosis of mature erythroid progenitor cells in the absence of erythropoietin.
Blood. 95: 3742-3749, 2000 
 

著書・総説

西村直矢, 土師正二郎, 本園千尋
結核菌を認識するあらたなC型レクチン受容体
医学のあゆみ Volume 261, Issue 13 (2017), 1243 - 1244
 
Podack ER, Deyev V, Shiratsuchi M.
Pore formers of the immune system.
Adv Exp Med Biol. 598: 325-341, 2007 
 
白土基明
ウイルス感染と血球貪食症候群
血液フロンティア 2013;23:61-68.
 
安部康信, 大島孝一.
EBV関連リンパ腫をどう理解するか
症例検討を通して学ぶ悪性リンパ腫診療の実際-リンフォーマ井戸端会議から学んだこと-:
メディカルレビュー社; 97-102, 2010
 
牟田耕一郎, 安部康信.
サラセミア
専門医のための薬物療法Q&A:
中外医学社; 92-98, 2007
 
白土基明, 牟田耕一郎.
先天性疾患における輸血依存性鉄過剰症の病態
Iron Overloadと鉄キレート療法:
メディカルレビュー社; 117-122, 2007
 

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