研究室紹介
総合消化器研究室 消化器グループ
原著論文
Esaki M, Ihara E, Manabe N, Kawami N, Iwakiri K, Akiyama J, Kuribayashi S, Uraoka T, Ogino H, Chinen T, Misumi A, Watanabe H, Suzuki M, Kishimoto J, Ogawa Y: Evaluating the efficacy and safety of acotiamide in patients with esophagogastric junction outflow obstruction: study protocol for an investigator-initiated, multi-center,randomized, double-blind, placebo-controlled phase II trial.
Trials 24(1): 459, 2023
Kawasaki A, Tsuji K, Uedo N, Kanesaka T, Miyamoto H, Gushima R, Minoda Y, Ihara E, Amano R, Yao K, Naito Y, Aoyagi H, Iwasaki T, Uchita K, Arima H, Doyama H: Non-atrophic gastric mucosa is an independent associated factor for superficial non-ampullary duodenal epithelial tumors: a multicenter, matched, case-control study.
Clin Endosc 56(1): 75-82, 2023
Minoda Y, Esaki M, Ihara E, Nagatomo S, Nishioka K, Fujimori N, Ogino H, Bai X, Tanaka Y, Chinen T, Hu Q, Ota M, Umekita S, Yamamoto H, Ogawa Y: Auxilliary diagnosis of subepithelial lesions by impedance measurement during endoscopic ultrasound fine-needle aspiration biopsy.
Gastrointest Endosc 97(5): 977-984, 2023
Minoda Y, Ihara E, Itaba S, Sumida Y, Haraguchi K, Aso A, Mizutani T, Osoegawa T, Esaki M, Nagatomo S, Nishioka K, Muta K, Bai X, Ogino H, Fujimori N, Tsurumaru D, Ohuchida K, Qingjiang H, Oki E, Yamamoto H, Ogawa Y: Negligible procedure-related dissemination risk of mucosal incision-assisted biopsy for gastrointestinal stromal tumors versus endoscopic ultrasound-guided fine-needle aspiration/biopsy.
Surg Endosc 37(1): 101-108, 2023
Hata Y, Sato H, Shimaura Y, Abe H, Shiwaku A, Shiota J, Sato C, Ominami M, Fukuda H, Ogawa R, Nakamura J, Tatsuta T, Ikebuchi Y, Yokomichi H, Ihara E, Inoue H: Impact of peroral endoscopic myotomy on high-resolution manometry findings and their association with the procedure’s outcomes.
Gastrointest Endosc 97(4): 673-683.e2, 2023
Igarashi HY, Ihara E, Bai X, Higashi C, Ikeda H, Tanaka Y, Hirano M, Ogino H, Chinen T, Taguchi Y, Ogawa Y: Determination of region-specific roles of the M3 muscarinic acetylcholine receptor in gastrointestinal motility.
Dig Dis Sci 68(2): 439-450,2023
Esaki M, Ihara E, Sumida Y, Fujii H, Takahashi S, Haraguchi K, Iwasa T, Somada S, Minoda Y, Ogino H, Tagawa K, Ogawa Y: Hybrid- and conventional endoscopic submucosal dissection for early gastric neoplasm: a multi-center randomized controlled trial.
Clin Gastroenterol Hepatol 21(7):1810-1818.e8, 2023
Ogino H, Morikubo H, Fukaura K, Okui T, Gardiner S, Sugiyama N, Yoshii N, Kawaguchi T, Chen H, Nonnenmacher E, Setoguchi S, Nakashima N, Kobayashi T: Validation of a claims-based algorithm to identify cases of ulcerative colitis in Japan. J Gastroenterol Hepatol37(3):499-506, 2022
Yamakawa M, Nakane S, Ihara E, Tawara N, Ikeda H, Igarashi Y, Komohara Y, Takamatsu K, Ikeda T, Tomita Y, Murai S, Ando Y, Mukaino A, Ogawa Y, Ueda M: A novel murine model of autoimmune dysautonomia by alpha3 nicotinic acetylcholine receptor immunization. Front Neurosci 161006923, 2022
Sasaki T, Kohashi K, Kawatoko S, Ihara E, Oki E, Nakamura M, Ogawa Y, Oda Y: Tumor progression by epithelial-mesenchymal transition in arid1a- and smarca4-aberrant solid-type poorly differentiated gastric adenocarcinoma. Virchows Arch 480(5): 1063-1075, 2022
Ohkubo A, Osoegawa T, Harada N, Iboshi Y, Sumida Y, Nakamuta M, Suematsu E, Kobayashi H, Ihara E: A rare case of rheumatoid arthritis with tocilizumab-induced intestinal mucosal injury. Intern Med 61(7): 1011-1014, 2022
Minoda Y, Ogino H, Sumida Y, Osoegawa T, Itaba S, Hashimoto N, Esaki M, Kitagawa Y, Yodoe K, Iboshi Y, Matsuguchi T, Tadokoro M, Chaen T, Kubo H, Kubokawa M, Harada N, Nishizima K, Fujii H, Hata Y, Tanaka Y, Ihara E, Ogawa Y: Is a small-caliber or large-caliber endoscope more suitable for colonic self-expandable metallic stent placement? A randomized controlled study. Therap Adv Gastroenterol 1517562848211065331, 2022
Minoda Y, Ihara E, Itaba S, Sumida Y, Haraguchi K, Aso A, Mizutani T, Osoegawa T, Esaki M, Nagatomo S, Nishioka K, Muta K, Bai X, Ogino H, Fujimori N, Tsurumaru D, Ohuchida K, Qingjiang H, Oki E, Yamamoto H, Ogawa Y: Negligible procedure-related dissemination risk of mucosal incision-assisted biopsy for gastrointestinal stromal tumors versus endoscopic ultrasound-guided fine-needle aspiration/biopsy. Surg Endosc 2022
Minoda Y, Ihara E, Fujimori N, Nagatomo S, Esaki M, Hata Y, Bai X, Tanaka Y, Ogino H, Chinen T, Hu Q, Oki E, Yamamoto H, Ogawa Y: Efficacy of ultrasound endoscopy with artificial intelligence for the differential diagnosis of non-gastric gastrointestinal stromal tumors. Sci Rep 12(1): 16640, 2022
Minoda Y, Esaki M, Ihara E, Nagatomo S, Nishioka K, Fujimori N, Ogino H, Bai X, Tanaka Y, Chinen T, Hu Q, Ota M, Umekita S, Yamamoto H, Ogawa Y: Auxiliary diagnosis of subepithelial lesions by impedance measurement during endoscopic ultrasound guided fine-needle biopsy. Gastrointest Endosc 2022
Matsumoto K, Fujimori N, Hata Y, Minoda Y, Murakami M, Teramatsu K, Takamatsu Y, Takeno A, Oono T, Ihara E, Nakata K, Nakamura M, Yamamoto T, Koga Y, Oda Y, Ito T, Ogawa Y: Ampullary neuroendocrine neoplasm: Clinicopathological characteristics and novel endoscopic entity. Dig Dis 2022
Iwakiri K, Fujiwara Y, Manabe N, Ihara E, Kuribayashi S, Akiyama J, Kondo T, Yamashita H, Ishimura N, Kitasako Y, Iijima K, Koike T, Omura N, Nomura T, Kawamura O, Ohara S, Ozawa S, Kinoshita Y, Mochida S, Enomoto N, Shimosegawa T, Koike K: Evidence-based clinical practice guidelines for gastroesophageal reflux disease 2021. J Gastroenterol 57(4): 267-285, 2022
Ihara E, Ogino H, Muta K, Hamada S, Wada M, Hata Y, Ikeda H, Bai X, Minoda Y, Esaki M, Tanaka Y, Chinen T, Ogawa Y: The treatment effects of acotiamide in esophagogastric outflow obstruction: A prospective longitudinal observational study. Esophagus 19(2): 332-342, 2022
Iboshi Y, Sumida Y, Ihara E, Fujii H, Harada N, Nakamuta M, Ogawa Y: Over-the-catheter endoscope replacement for stenting in patients with inaccessible malignant colonic obstruction with coexisting peritoneal carcinomatosis. Dig Endosc 2022
Hata Y, Ihara E, Wada M, Tsuru H, Muta K, Minoda Y, Bai X, Esaki M, Tanaka Y, Chinen T, Ogino H, Sakamoto R, Ogawa Y: Improved esophagography screening for esophageal motility disorders using wave appearance and supra-junctional ballooning. J Gastroenterol 57(11): 838-847, 2022
Hamada S, Ihara E, Yoshitake C, Inada T, Fukuya H, Ohkubo A, Tomoeda N, Iboshi Y, Sumida Y, Yoshimura D, Nakamuta M, Harada N: Clip stopper closure method using a detachable snare in combination with zeoclip for endoscopic submucosal dissection-induced mucosal defects. Dig Endosc 2022
Hamada S, Ihara E, Muta K, Wada M, Hata Y, Ikeda H, Tanaka Y, Ogino H, Chinen T, Ogawa Y: Onigiri esophagography as a screening test for esophageal motility disorders. J Neurogastroenterol Motil 28(1): 43-52, 2022
Fukuda S, Ichida K, Kitagawa Y, Nakano K, Chaen T, Yoshimura D, Ochiai T, Ihara E, Ogawa Y: An adult case of congenital duodenal diaphragm that was successfully treated by endoscopic resection using a grasping-type scissor forceps. DEN Open 2e93, 2022
Esaki M, Yamakawa S, Ichijima R, Suzuki S, Kusano C, Ikehara H, Minoda Y, Ihara E, Gotoda T: Self-completion method of endoscopic submucosal dissection using the endosaber for treating colorectal neoplasms (with video). Sci Rep 12(1): 5821, 2022
Esaki M, Minoda Y, Ihara E: In living color: Linked color imaging for the detection of early gastric cancer. Dig Dis Sci 67(6): 1922-1924, 2022
Esaki M, Maehara R, Nagatomo S, Nishioka K, Minoda Y, Ogino H, Ihara E: Application of traction-method to hybrid endoscopic submucosal dissection for gastrointestinal tumors. Endoscopy 54(4): E160-E161, 2022
Esaki M, Ihara E, Sumida Y, Fujii H, Takahashi S, Haraguchi K, Iwasa T, Somada S, Minoda Y, Ogino H, Tagawa K, Ogawa Y: Hybrid- and conventional endoscopic submucosal dissection for early gastric neoplasms: A multi-center randomized controlled trial. Clin Gastroenterol Hepatol 2022
Esaki M, Ihara E, Fujii H, Sumida Y, Haraguchi K, Takahashi S, Iwasa T, Nakano K, Wada M, Somada S, Minoda Y, Ogino H, Tagawa K, Ogawa Y: Comparison of the procedure time differences between hybrid endoscopic submucosal dissection and conventional endoscopic submucosal dissection in patients with early gastric neoplasms: A study protocol for a multi-center randomized controlled trial (hybrid-g trial). Trials 23(1): 166, 2022
Esaki M, Ihara E, Esaki M, Nishioka K, Kimura Y, Hata Y, Tsuru H, Wada M, Minoda Y, Bai X, Shoguchi Y, Nasu T, Nagatomo S, Muta K, Ogino H, Ogawa Y: Comparisons of outcomes between proknife injection endoscopic submucosal dissection and conventional endoscopic submucosal dissection for large gastric lesions in ex vivo porcine model study: A randomized controlled trial. DEN open 2(1): e91, 2022
Otsuka Y, Bai X, Tanaka Y, Ihara E, Chinen T, Ogino H, Ogawa Y: Involvement of interstitial cells of cajal in nicotinic acetylcholine receptor-induced relaxation of the porcine lower esophageal sphincter. Eur J Pharmacol 910174491, 2021
Okuno H, Ogino H, Ihara E, Nishioka K, Tanaka Y, Chinen T, Kohjima M, Oono T, Tanaka M, Goya T, Fujimori N, Iboshi Y, Gotoda T, Ogawa Y: Discriminant equation using mucosally expressed cytokines and transcription factor for making definite diagnosis of inflammatory bowel disease unclassified. BMC Gastroenterol 21(1): 73, 2021
Okuno H, Ogino H, Ihara E, Nishioka K, Iboshi Y, Chinen T, Ochiai T, Akiho H, Nakamura K, Gotoda T, Ogawa Y: Interleukin-1beta as a predictor of glucocorticoid response in ulcerative colitis. Digestion 102(3): 357-367, 2021
Ogino H, Fukaura K, Iboshi Y, Nagamatsu Y, Okuno H, Nishioka K, Nishihara Y, Tanaka Y, Chinen T, Ihara E, Ogawa Y: Role of the il-23-t-bet/gata3 axis for the pathogenesis of ulcerative colitis. Inflammation 44(2): 592-603, 2021
Nishioka K, Ogino H, Chinen T, Ihara E, Tanaka Y, Nakamura K, Ogawa Y: Mucosal il23a expression predicts the response to ustekinumab in inflammatory bowel disease. J Gastroenterol 56(11): 976-987, 2021
Nishihara Y, Ogino H, Tanaka M, Ihara E, Fukaura K, Nishioka K, Chinen T, Tanaka Y, Nakayama J, Kang D, Ogawa Y: Mucosa-associated gut microbiota reflects clinical course of ulcerative colitis. Sci Rep 11(1): 13743, 2021
Nasu T, Esaki M, Shoguchi Y, Bai X, Minoda Y, Ogino H, Ihara E: Traction-assisted hybrid endoscopic submucosal dissection for small rectal neuroendocrine tumors. Endoscopy 2021
Nakane S, Mukaino A, Ihara E, Ogawa Y: Autoimmune gastrointestinal dysmotility: The interface between clinical immunology and neurogastroenterology. Immunol Med 44(2): 74-85, 2021
Nagatomo S, Minoda Y, Ihara E: Double scope recovery technique to manage procedure-related trouble during wire trimming with a loop cutter. Dig Endosc 33(4): e83-e84, 2021
Muta K, Ihara E, Hamada S, Ikeda H, Wada M, Hata Y, Bai X, Nishihara Y, Tanaka Y, Ogino H, Ogawa Y: Physiological and pathological roles of the accommodation response in lower esophageal sphincter relaxation during wet swallows. Sci Rep 11(1): 7898, 2021
Minoda Y, Hisamatsu Y, Ihara E: Usefulness of preoperative site marking with an indocyanine green fluorescent clip for gastrointestinal stromal tumor. Dig Endosc 33(5): e95-e96, 2021
Hamada S, Ihara E, Ikeda H, Muta K, Ogino H, Chinen T, Tanaka Y, Ogawa Y: Clinical characterization of vonoprazan-refractory gastroesophageal reflux disease. Digestion 102(2): 197-204, 2021
Fujimori N, Osoegawa T, Aso A, Itaba S, Minoda Y, Murakami M, Matsumoto K, Teramatsu K, Takamatsu Y, Takaoka T, Oono T, Ihara E, Yoshizumi T, Ohtsuka T, Nakamura M, Ogawa Y: Efficacy of early endoscopic ultrasound-guided transluminal drainage for postoperative pancreatic fistula. Can J Gastroenterol Hepatol 20216691705, 2021
Esaki M, Minoda Y, Wada M, Sakisaka S, Tsuruta S, Hosokawa T, Matsuguchi T, Ichijima R, Suzuki S, Tamura Y, Iwao A, Yamakawa S, Irie A, Ihara E, Ogawa Y: Self-completion method of endoscopic submucosal dissection using endosaber without any other device or assistance: An ex vivo porcine model study. Digestion 102(2): 139-146, 2021
Esaki M, Ihara E, Hashimoto N, Abe S, Aratono C, Shiga N, Sumida Y, Fujii H, Haraguchi K, Takahashi S, Iwasa T, Nakano K, Wada M, Somada S, Nishioka K, Minoda Y, Ogino H, Ogawa Y: Efficacy of hybrid endoscopic submucosal dissection with souten in gastric lesions: An ex vivo porcine model basic study. World J Gastrointest Surg 13(6): 563-573, 2021
Esaki M, Ihara E, Gotoda T: Endoscopic instruments and techniques in endoscopic submucosal dissection for early gastric cancer. Expert Rev Gastroenterol Hepatol 15(9): 1009-1020, 2021
Esaki M, Horii T, Ichijima R, Wada M, Sakisaka S, Abe S, Tomoeda N, Kitagawa Y, Nishioka K, Minoda Y, Tsuruta S, Suzuki S, Akiho H, Ihara E, Ogawa Y, Gotoda T: Assistant skill in gastric endoscopic submucosal dissection using a clutch cutter. World J Gastrointest Surg 13(2): 116-126, 2021
Esaki M, Esaki M, Maehara K, Minoda Y, Ogino H, Ihara E, Ogawa Y: Rubber band-assisted, one-person-operated cold snare polypectomy for colorectal polyps. Endosc Int Open 9(11): E1845-E1846, 2021
Tsuruta S, Kohashi K, Yamada Y, Fujiwara M, Koga Y, Ihara E, Ogawa Y, Oki E, Nakamura M, Oda Y: Solid-type poorly differentiated adenocarcinoma of the stomach: Deficiency of mismatch repair and swi/snf complex. Cancer Sci 111(3): 1008-1019, 2020
Oyama K, Ohuchida K, Shindo K, Moriyama T, Hata Y, Wada M, Ihara E, Nagai S, Ohtsuka T, Nakamura M: Thoracoscopic surgery combined with endoscopic creation of a submucosal tunnel for a large complicated esophageal leiomyoma. Surg Case Rep 6(1): 92, 2020
Minoda Y, Ihara E, Ogino H, Komori K, Otsuka Y, Ikeda H, Esaki M, Chinen T, Matsuguchi T, Takahashi S, Shiga N, Yoshimura R, Ogawa Y: The efficacy and safety of a promising single-channel endoscopic closure technique for endoscopic treatment-related artificial ulcers: A pilot study. Gastrointest Tumors 7(1-2): 21-29, 2020
Minoda Y, Ihara E, Komori K, Ogino H, Otsuka Y, Chinen T, Tsuda Y, Ando K, Yamamoto H, Ogawa Y: Efficacy of endoscopic ultrasound with artificial intelligence for the diagnosis of gastrointestinal stromal tumors. J Gastroenterol 55(12): 1119-1126, 2020
Minoda Y, Chinen T, Osoegawa T, Itaba S, Haraguchi K, Akiho H, Aso A, Sumida Y, Komori K, Ogino H, Ihara E, Ogawa Y: Superiority of mucosal incision-assisted biopsy over ultrasound-guided fine needle aspiration biopsy in diagnosing small gastric subepithelial lesions: A propensity score matching analysis. BMC Gastroenterol 20(1): 19, 2020
Harada N, Hirowatari M, Ihara E, Ishihara E, Inoue M, Miyamura T, Nakamuta M: A case of suspicious allergic reaction to peracetic acid following endoscopy. Clin Endosc 53(6): 743-745, 2020
Fujimori N, Minoda Y, Murakami M, Suehiro Y, Oono T, Ihara E, Ogawa Y: Endoscopic removal of a lumen-apposing metal stent that migrated into the walled-off necrosis during the first drainage procedure. Endoscopy 52(2): E51-E52, 2020
Esaki M, Minoda Y, Ihara E, Sakisaka S, Tsuruta S, Hosokawa T, Wada M, Hata Y, Suzuki S, Iwao A, Yamakawa S, Irie A, Akiho H, Ogawa Y: Efficacy of traction, using a clip-with-thread, for esophageal endoscopic submucosal dissection for esophageal lesions with fibrosis in an ex vivo pig training model. Turk J Gastroenterol 31(1): 58-64, 2020
Esaki M, Hayashi Y, Ikehara H, Ihara E, Horii T, Tamura Y, Ichijima R, Yamakawa S, Irie A, Shibuya H, Suzuki S, Kusano C, Minoda Y, Akiho H, Ogawa Y, Gotoda T: The effect of scissor-type versus non-scissor-type knives on the technical outcomes in endoscopic submucosal dissection for superficial esophageal cancer: A multi-center retrospective study. Dis Esophagus 33(4): 2020
Esaki M, Haraguchi K, Akahoshi K, Tomoeda N, Aso A, Itaba S, Ogino H, Kitagawa Y, Fujii H, Nakamura K, Kubokawa M, Harada N, Minoda Y, Suzuki S, Ihara E, Ogawa Y: Endoscopic mucosal resection vs endoscopic submucosal dissection for superficial non-ampullary duodenal tumors. World J Gastrointest Oncol 12(8): 918-930, 2020
Tsuruta S, Ohishi Y, Fujiwara M, Ihara E, Ogawa Y, Oki E, Nakamura M, Oda Y: Gastric hepatoid adenocarcinomas are a genetically heterogenous group; most tumors show chromosomal instability, but msi tumors do exist. Hum Pathol 8827-38, 2019
Osoegawa T, Minoda Y, Ihara E, Komori K, Aso A, Goto A, Itaba S, Ogino H, Nakamura K, Harada N, Makihara K, Tsuruta S, Yamamoto H, Ogawa Y: Mucosal incision-assisted biopsy versus endoscopic ultrasound-guided fine-needle aspiration with a rapid on-site evaluation for gastric subepithelial lesions: A randomized cross-over study. Dig Endosc 31(4): 413-421, 2019
Minoda Y, Ogino H, Chinen T, Ihara E, Haraguchi K, Akiho H, Takizawa N, Aso A, Tomita Y, Esaki M, Komori K, Otsuka Y, Iwasa T, Ogawa Y: Objective validity of the japan narrow-band imaging expert team classification system for the differential diagnosis of colorectal polyps. Dig Endosc 31(5): 544-551, 2019
Minoda Y, Fujimori N, Ihara E: Forward-viewing endoscopic ultrasound-guided fine-needle biopsy using the clip-with-thread method for small gastric subepithelial lesions. Dig Endosc 31(6): e103-e104, 2019
Komori K, Ihara E, Minoda Y, Ogino H, Sasaki T, Fujiwara M, Oda Y, Ogawa Y: The altered mucosal barrier function in the duodenum plays a role in the pathogenesis of functional dyspepsia. Dig Dis Sci 64(11): 3228-3239, 2019
Fukaura K, Iboshi Y, Ogino H, Ihara E, Nakamura K, Nishihara Y, Nishioka K, Chinen T, Iwasa T, Aso A, Goto A, Haraguchi K, Akiho H, Harada N, Ogawa Y: Mucosal profiles of immune molecules related to t helper and regulatory t cells predict future relapse in patients with quiescent ulcerative colitis. Inflamm Bowel Dis 25(6): 1019-1027, 2019
Bai X, Ihara E, Otsuka Y, Tsuruta S, Hirano K, Tanaka Y, Ogino H, Hirano M, Chinen T, Akiho H, Nakamura K, Oda Y, Ogawa Y: Involvement of different receptor subtypes in prostaglandin e2-induced contraction and relaxation in the lower esophageal sphincter and esophageal body. Eur J Pharmacol 857172405, 2019
H. Hayashi, M. Esaki, S. Suzuki, T. Hosokawa, Y. Tanaka, T. Mizutani, S. Tsuruta, A. Iwao, S. Yamakawa, A. Irie, Y. Minoda, Y. Hata, H. Ogino, H. Akiho, E. Ihara, Y. Ogawa. The efficacy of scissor-type knife in endoscopic submucosal dissection for early gastric neoplasms: a propensity score matching analysis. World Journal of Gastrointestinal Oncology. 10:487-495,2018
Campbell C, Dikiy S, Bhattarai SK, Chinen T, Matheis F, Calafiore M, Hoyos B, Hanash A, Mucida D, Bucci V, Rudensky AY. Extrathymically Generated Regulatory T Cells Establish a Niche for Intestinal Border-Dwelling Bacteria and Affect Physiologic Metabolite Balance. Immunity. 48:1245-1257,2018
M. Esaki, S. Suzuki, Y. Hayashi, A. Yokoyama, S. Abe, T. Hosokawa, S. Tsuruta, Y. Minoda, Y. Hata, H. Ogino, H. Akiho, E. Ihara and Y. Ogawa. Propensity score-matching analysis to compare clinical outcomes of endoscopic submucosal dissection for early gastric cancer in the postoperative and non-operative stomachs. BMC Gastroenterol 18:125, 2018
A. Mukaino, H. Minami, H. Isomoto, H. Hamamoto, E. Ihara. Y. Maeda, O. Higuchi, T. Okanishi, Y. Kokudo, K. Deguchi, F. Sasaki, T. Ueki, K. Murata, T. Yoshida, M. Kinjo, Y. Ogawa, A. Ido, H. Matsuo, K. Nakao, S. Nakane. Anti-ganglionic acetylcholine receptor antibodies in Japanese patients with motility disorders. J Gastroenterol 53:1227-1240, 2018
T. Iwasa, R. Nakadate, S. Onogi, Y. Okamoto, J. Arata, S. Oguri, H. Ogino H, E. Ihara, K. Ohuchida, T. Akahoshi, T. Ikeda, Y. Ogawa, M. Hashizume. A new robotic-assisted flexible endoscope with single-hand control: endoscopic submucosal dissection in the ex vivo porcine stomach. Surgical Endoscopy 32:3386-3392, 2018
K. Fukaura, E. Ihara, H. Ogino, Y. Iboshi, K. Muta, X. Bai, S. Hamada, Y. Hata, T. Iwasa, A. Aso, K. Nakamura, Y. Ogawa. Mucosally expressed cytokines are associated with the esophageal motility function. Digestion 98:95-103, 2018
M. Esaki, S. Suzuki, Y. Hayashi, A. Yokoyama, S. Abe, T. Hosokawa, H. Ogino, H. Akiho, E. Ihara, Y. Ogawa. Splash M-knife versus Flush Knife BT in the technical outcomes of endoscopic submucosal dissection for early gastric cancer: a propensity score matching analysis. BMC Gastroenterol 18:35, 2018
K. Nakano, H. Yamamoto, M. Fujiwara, Y. Koga, S. Tsuruta, E. Ihara, E. Oki, M. Nakamura, Y. Ogawa, Y. Oda. Clinicopathogenic and molecular characteristics of synchronous colorectal carcinoma with mismatch repair deficiency. Am J Surg Pathol 42:172-182, 2018
Bai X, Ihara E, Hirano K, Tanaka Y, Nakano K, Kita S, Iwamoto T, Ogino H, Hirano M, Nakamura K, Ogawa Y. Endogenous hydrogen sulfide contributes to tone generation in porcine lower esophageal sphincter via Na+/Ca2+ exchanger. Cell Mol Gastroenterol Hepatol 5;209-221, 2017
Otsuka Y, Akahoshi K, Yasunaga K, Kubokawa M, Gibo J, Osada S, Tokumaru K, Miyamoto K, Sato T, Shiratsuchi Y, Oya M, Koga H, Ihara E and Nakamura K. Clinical outcome of Clutch Cutter endoscopic submucosal dissection for older patients with early gastric cancer. World J Gastrointest Oncol 9:416-422, 2017
Motomura Y, Akahoshi K, Kajiyama K, Gibo J, Miyamoto K, Ikeda H, Yamaguchi E, Teramatsu K, Utsunomiya R, Miyagaki A, Ooya M and Ihara E. Utility of lavage cytology plus targeted biopsy during cholangioscopy for the diagnosis of indeterminate biliary lesions. Gastroenterol Hepatol Endosc 2:1-4, 2017
Akahoshi K, Kubokawa M, Gibo J, Osada S, Tokumaru K, Yamaguchi E, Ikeda H, Sato T, Miyamoto K, Kimura Y, Shiratsuchi Y, Oya M, Koga H, Ihara E, Nakamura K. Endoscopic submucosal dissection of gastric adenoma using the clutch cutter. World J Gastrointest Endosc. 9:334-340, 2017
Komori K, Kubokawa M, Ihara E, Akahoshi K, Nakamura K, Motomura K, Masumoto A. Prognostic factors associated with mortality in patients with gastric fundal varieal bleeding World J Gastroenterol. 23:496-504, 2017
Bai X, Tanaka Y, Ihara E, Hirano K, Nakano K, Hirano M, Oda Y and Nakamura K. Trypsin induces biphasic muscle contraction and relaxation via transient receptor vanilloid 1 and neurokinin receptor 1/2 in porcine esophageal body. Eur J Pharmacol. 797:65-74, 2017
Akahoshi K, Kubokawa M, Gibo J, Osada S, Tokumaru K, Shiratsuchi Y, Oya M, Ihara E, Nakamura K. Endoscopic resection using the Clutch Cutter and a detachable snare for large pedunculated colonic polyps. Endoscopy 49:54-58, 2017
Chinen T, Kannan AK, Levine AG, Fan X, Klein U, Gasteiger G, Feng Y, Fontenot JD, Rudensky AY.An essential role for the IL-2 receptor in Treg cell function.Nat Immunol. 17:1322-1333, 2016
Tanaka Y, Ihara E, Nakamura K, Muta K, Fukaura K, Mukai K, Xiaopeng B, Takayanagi R: Clinical characteristics associated with esophageal motility function. J Gastroenterol Hepatol 31:1133-1140, 2016
Nakamura K, Ihara E, Akiho H, Akahoshi K, Harada N, Ochiai T, Nakamura N, Ogino H, Iwasa T, Aso A, Iboshi Y, Takayanagi R: Limited effects of rebamipide in addition to proton pump inhibitor (PPI) in the treatment of post-endoscopic submucosal dissection gastric ulcers: a randomized controlled trial comparing PPI plus rebamipide combination therapy with PPI monotherapy. Gut and Liver 10:917-924, 2016
Muta K, Ihara E, Fukaura K, Tsuchida O, Ochiai T, Nakamura K: Effects of acotiamide on esophageal motility function in patients with esophageal motility disorders: a pilot study. Digestion 94:9-16, 2016
Komori K, Nakamura K, Ihara E, Iwasa T, Hirahashi M, Oda Y, Takayanagi R: Endoscopic submucosal dissection is feasible for very elderly patients with early gastric cancer: comparison of short-term and long-term outcomes in very elderly and non-elderly patients. Fukuoka Acta Medica 107:72-81, 2016
Aso A, Yoshinaga S: Future potential means of diagnosing gastric subepithelial lesions: Beyond conventional endoscopic ultrasound and endoscopic ultrasound-guided fine-needle aspiration. Dig Endosc Suppl1:32-33, 2016
Nakamura K, Osada M, Goto A, Iwasa T, Takahashi S, Takizawa N, Akahoshi K, Ochiai T, Nakamura N, Akiho H, Itaba S, Harada N, Iji M, Tanaka M, Kubo H, Somada S, Ihara E, Oda Y, Ito T, Takayanagi R: Short- and long-term outcomes of endoscopic resection of rectal neuroendocrine tumors: analyses according to the WHO 2010 classification. Scand J Gastroenterol 51:448-455, 2016
Tanaka Y, Ihara E, Hirano K, Takahashi S, Hirano M, Nakamura K, Akiho H, Oda Y, Takayanagi R: Trypsin-induced biphasic regulation of tone in the porcine lower esophageal sphincter. Eur J Phamacol 752:97-105, 2015
Ihara E, Yu Q, Chappellaz M, MacDonald JA: ERK and p38MAPK pathways regulate myosin light chain phosphatase and contribute to Ca2+ sensitization of intestinal smooth muscle contraction. Neurogastroenterol Motil 27:135-146, 2015
Feng Y, Arvey A, Chinen T, van der Veeken J, Gasteiger G, Rudensky AY.Control of the inheritance of regulatory T cell identity by a cis element in the Foxp3 locus.Cell. 158:749-63, 2014
Osada M, Aishima S, Hirahashi M, Takizawa N, Takahashi S, Nakamura K, Tanaka M, Maehara Y, Takayanagi R, Oda Y: Combination of hepatocellular markers is useful for prognostication in gastric hepatoid adenocarcinoma. Human Pathology 45:1243-1250, 2014
Iboshi Y, Nakamura K, Ihara E, Iwasa T, Akiho H, Harada N, Nakamuta M, Takayanagi R: Multigene analysis unveils distinctive expression profiles of helper T cell-related genes in the intestinal mucosa that discriminate between ulcerative colitis and Crohn' disease. Inflammatory Bowel Diseases 20:967-977, 2014
Akiho H, Tokita Y, Nakamura K, Satoh K, Nishiyama M, Tsuchiya N, Tsuchiya K, Ohbuchi K, Iwakura Y, Ihara E, Takayanagi R, Yamamoto M: Involvement of interleukin-17A-induced hypercontractility of intestinal smooth muscle cells in persistent gut motor dysfunction. PLOS ONE 9:e92960, 2014
Aso A, Ihara E, Osoegawa T, Nakamura K, Itaba S, Igarashi H, Ito T, Aishima S, Oda Y, Tanaka M, Takayanagi R: Key endoscopic ultrasound features of pancreatic ductal adenocarcinoma smaller than 20 mm. Scand J Gastroenterol 49:332-338, 2014
Ihara E, Matsuzaka H, Honda K, Hata Y, Sumida Y, Akiho H, Misawa T, Toyoshima S, Chijiiwa Y, Nakamura K, Takayanagi R: Mucosal-incision assisted biopsy for suspected gastric gastrointestinal stromal tumors. World J Gastrointest Endosc 5:191-196, 2013
Akahoshi K, Minoda Y, Komori K, Motomura Y, Kubokawa M, Otsuka Y, Hamada S, Fukuda S, Iwao R, Gibo J, Oya M, Nakamura K: Endoscopic submucosal dissection using the "Clutch Cutter" for early esophageal squamous cell carcinoma. Endoscopy 45:1035-1038, 2013
Itaba S, Nakamura K, Aso A, Tokunaga S, Akiho H, Ihara E, Iboshi Y, Iwasa T, Akahoshi K, Ito T, Takayanagi R: Prospective, randomized, double-blind, placebo-controlled trial of ulinastatin for prevention of hyperenzymemia after double balloon endoscopy via the antegrade approach. Dig Endosc 25:421-427, 2013
Higuchi N, Nakamura K, Ihara E, Akahoshi K, Akiho H, Sumida Y, Motomura Y, Kubokawa M, Ito T, Takayanagi R: Preserved gastric motility in patients with early gastric cancer after endoscopic submucosal dissection. J Gastroenterol Hepatol 28:494-498, 2013
Josefowicz S, Niec R, Kim HY, Treuting P, Chinen T, Umetsu DT, Rudensky AY. Extrathymically generated regulatory T cells control mucosal Th2 inflammation. Nature. 482:395-9, 2012
Ihara E, Chappellaz M, Turner SR, MacDonald JA: The contribution of protein kinase C and CPI-17 signaling pathways to hypercontractility in murine experimental colitis. Neurogastroenterol Motil 24:e15-26, 2012
Iwasa T, Ogino H, Nakamura K, Ihara E, Akiho H, Takayanagi R: Feeding administration of Daikenchuto suppresses colitis induced by naive CD4+ T cell transfer into SCID mice. Dig Dis Sci 57:2571-2579, 2012
Somada S, Muta H, Nakamura K, Sun X, Honda K, Ihara E, Akiho H, Takayanagi R, Yoshikai Y, Podack ER, Tani K: CD30 ligand/CD30 interaction is involved in pathogenesis of inflammatory bowel disease. Dig Dis Sci 57: 2031-2037, 2012
Ogino H, Nakamura K, Iwasa T, Ihara E, Akiho H, Motomura Y, Akahoshi K, Igarashi H, Kato M, Kotoh K, Ito T, Takayanagi R: Regulatory T cells expanded by rapamycin in vitro suppress colitis in an experimental mouse model. J Gastroenterol 47: 366-376, 2012
Ihara E, Chappellaz M, Turner SR, MacDonald JA: The contribution of protein kinase C and CPI-17 signaling pathways to hypercontractility in murine experimental colitis. Neurogastroenterol Motil 24:e15-26, 2012
Chinen T, Komai K, Muto G, Morita R, Inoue N, Yoshida H, Sekiya T, Nakamura K, Yoshimura A. Prostaglandin E2 and SOCS1 have a role in intestinal immune tolerance. Nat Commun. 2:190, 2011
Takahashi R, Nishimoto S, Muto G, Sekiya T, Tamiya T, Kimura A, Morita R, Chinen T, Yoshimura A. SOCS1 is essential for Treg cell functions by preventing loss of Foxp3 expression as well as IFN-g and IL-17A production. J Exp Med. 208:2055-67, 2011
Itaba S, Iboshi Y, Nakamura K, Ogino H, Sumida Y, Aso A, Yoshinaga S, Akiho H, Igarashi H, Kato M, Kotoh K, Ito T, Takayanagi R: Low-frequency of bacteremia after endoscopic submucosal dissection of the stomach. Dig Endosc 23: 69-72, 2011
Goto A, Hirahashi M, Osada M, Nakamura K, Yao T, Tsuneyoshi M, Takayanagi R, Oda Y:
Aberrant activation-induced cytidine deaminase expression is associated with mucosal intestinalization in the early stage of gastric cancer. Virchows Arch 458: 717-724, 2011
Kanayama K, Nakamura K, Ogino H, Sumida Y, Ihara E, Akiho H, Takayanagi R: Th1 responses are more susceptible to infliximab-mediated immunosuppression than Th17 responses. Dig Dis Sci 56: 3525-3533, 2011
Ogino H, Nakamura K, Iwasa T, Ihara E, Akiho H, Motomura Y, Akahoshi K, Igarashi H, Kato M, Kotoh K, Ito T, Takayanagi R: Regulatory T Cells expanded by rapamycin in vitro suppress colitis in an experimental mouse model. J Gastroenterol 47: 366-376, 2012
Akiho H, Nakamura K: Daikenchuto ameliorated muscle hypercontractility in a murine T-cell-mediated persistent gut motor dysfunction model. Digestion 83: 173-179, 2011
Ogino H, Nakamura K, Ihara E, Akiho H, Takayanagi R: CD4+CD25+ regulatory T cells suppress Th17-responses in an experimental colitis model. Dig Dis Sci 56: 376-386, 2011
Iwasa T, Nakamura K, Ogino H, Itaba S, Akiho H, Okamoto R, Iboshi Y, Aso A, Murao H, Kanayama K, Ito T, Takayanagi R: Multiple ulcers in the small and large intestines occurred during tocilizumab therapy for rheumatoid arthritis. Endoscopy 43: 70-72, 2011
Akahoshi K, Honda K, Motomura Y, Kubokawa M, Okamoto R, Osoegawa T, Nakama N, Kashiwabara Y, Higuchi N, Tanaka Y, Oya M, Nakamura K: Endoscopic submucosal dissection using a grasping-type scissors forceps for early gastric cancers and adenomas. Dig Endosc 23: 24-29, 2011
Chinen T, Volchkov PY, Chervonsky AV, Rudensky AY. A critical role for regulatory T cell-mediated control of inflammation in the absence of commensal microbiota. J Exp Med. 207:2323-30, 2010
Mizutani T, Akiho H, Khan WI, Murao H, Ogino H, Kanayama K, Nakamura K, Takayanagi R: Persistent gut motor dysfunction in a murine model of T-cell-induced enteropathy. Neurogastroenterol Motil 22: 196-203, 2010
Yoshinaga M, Kitamura Y, Chaen T, Yamashita S, Tsuruta S, Hisano T, Ikeda Y, Sakai H, Nakamura K, Takayanagi R, Muto Y: The simultaneous expression of peroxisome proliferator-activated receptor delta and cyclooxygenase-2 may enhance angiogenesis and tumor venous invasion in tissues of colorectal cancers. Dig Dis Sci 54: 1108-1114, 2009
Higuchi N, Sumida Y, Nakamura K, Itaba S, Yoshinaga S, Mizutani T, Honda K, Taki K, Murao H, Ogino H, Kanayama K, Akiho H, Goto A, Segawa Y, Yao T, Takayanagi R: Impact of double-balloon endoscopy on the diagnosis of jejunoileal involvement in primary intestinal follicular lymphomas: a case series. Endoscopy 41: 175-178, 2009
Kubo H, Nakamura K, Itaba S, Yoshinaga S, Kinukawa N, Sadamoto Y, Ito T, Yonemasu H, Takayanagi R: Differential diagnosis of cystic tumors of the pancreas by endoscopic ultrasonography. Endoscopy 41: 684-689, 2009
Ihara E, Moffat L, Borman MA, Amon JE, Walsh MP, MacDonald JA: Ca2+-independent contraction of longitudinal ileal smooth muscle is potentiated by a zipper-interacting protein kinase pseudosubstrate peptide. Am J Physiol Gastrointest Liver Physiol 297: G361-370, 2009
Ichiyama K, Yoshida H, Wakabayashi Y, Chinen T, Saeki K, Takaesu G, Hori S, Yoshimura A, Kobayashi T. Foxp3 inhibits RORgt-mediated IL-17A mRNA transcription through direct interaction with RORgt. J Biol Chem. 283:17003-8, 2008
Sumida Y, Nakamura K, Kanayama K, Akiho H, Teshima T, Takayanagi R: Preparation of functionally preserved CD4+CD25high regulatory T cells from leukapheresis products from ulcerative colitis patients, applicable to regulatory T-cell-transfer therapy. Cytotherapy 10: 698-710, 2008
Motomura Y, Ghia J-E, Wang H, Akiho H, El-Sharkawy RT, Collins M, Wan Y, McLaughlin JT, Khan WI: Enterochromaffin cell and 5-hydroxytryptamine responses to the same infectious agent differ in Th1 and Th2 dominant environments. Gut 57:475-481, 2008
Sun X, Somada S, Shibata K, Muta H, Yamada H, Yoshihara H, Honda K, Nakamura K, Takayanagi R, Tani K, Podack ER, Yoshikai Y: A critical role of CD30 ligand/CD30 in controlling inflammatory bowel diseases in mice. Gastroenterology 134: 447-58, 2008
Yoshinaga S, Gotoda T, Kusano C, Oda I, Nakamura K, Takayanagi R: Clinical impact of endoscopic submucosal dissection for superficial adenocarcinoma located at the esophagogastric junction. Gastrointest Endosc 67: 202-9, 2008
Trials 24(1): 459, 2023
Kawasaki A, Tsuji K, Uedo N, Kanesaka T, Miyamoto H, Gushima R, Minoda Y, Ihara E, Amano R, Yao K, Naito Y, Aoyagi H, Iwasaki T, Uchita K, Arima H, Doyama H: Non-atrophic gastric mucosa is an independent associated factor for superficial non-ampullary duodenal epithelial tumors: a multicenter, matched, case-control study.
Clin Endosc 56(1): 75-82, 2023
Minoda Y, Esaki M, Ihara E, Nagatomo S, Nishioka K, Fujimori N, Ogino H, Bai X, Tanaka Y, Chinen T, Hu Q, Ota M, Umekita S, Yamamoto H, Ogawa Y: Auxilliary diagnosis of subepithelial lesions by impedance measurement during endoscopic ultrasound fine-needle aspiration biopsy.
Gastrointest Endosc 97(5): 977-984, 2023
Minoda Y, Ihara E, Itaba S, Sumida Y, Haraguchi K, Aso A, Mizutani T, Osoegawa T, Esaki M, Nagatomo S, Nishioka K, Muta K, Bai X, Ogino H, Fujimori N, Tsurumaru D, Ohuchida K, Qingjiang H, Oki E, Yamamoto H, Ogawa Y: Negligible procedure-related dissemination risk of mucosal incision-assisted biopsy for gastrointestinal stromal tumors versus endoscopic ultrasound-guided fine-needle aspiration/biopsy.
Surg Endosc 37(1): 101-108, 2023
Hata Y, Sato H, Shimaura Y, Abe H, Shiwaku A, Shiota J, Sato C, Ominami M, Fukuda H, Ogawa R, Nakamura J, Tatsuta T, Ikebuchi Y, Yokomichi H, Ihara E, Inoue H: Impact of peroral endoscopic myotomy on high-resolution manometry findings and their association with the procedure’s outcomes.
Gastrointest Endosc 97(4): 673-683.e2, 2023
Igarashi HY, Ihara E, Bai X, Higashi C, Ikeda H, Tanaka Y, Hirano M, Ogino H, Chinen T, Taguchi Y, Ogawa Y: Determination of region-specific roles of the M3 muscarinic acetylcholine receptor in gastrointestinal motility.
Dig Dis Sci 68(2): 439-450,2023
Esaki M, Ihara E, Sumida Y, Fujii H, Takahashi S, Haraguchi K, Iwasa T, Somada S, Minoda Y, Ogino H, Tagawa K, Ogawa Y: Hybrid- and conventional endoscopic submucosal dissection for early gastric neoplasm: a multi-center randomized controlled trial.
Clin Gastroenterol Hepatol 21(7):1810-1818.e8, 2023
Ogino H, Morikubo H, Fukaura K, Okui T, Gardiner S, Sugiyama N, Yoshii N, Kawaguchi T, Chen H, Nonnenmacher E, Setoguchi S, Nakashima N, Kobayashi T: Validation of a claims-based algorithm to identify cases of ulcerative colitis in Japan. J Gastroenterol Hepatol37(3):499-506, 2022
Yamakawa M, Nakane S, Ihara E, Tawara N, Ikeda H, Igarashi Y, Komohara Y, Takamatsu K, Ikeda T, Tomita Y, Murai S, Ando Y, Mukaino A, Ogawa Y, Ueda M: A novel murine model of autoimmune dysautonomia by alpha3 nicotinic acetylcholine receptor immunization. Front Neurosci 161006923, 2022
Sasaki T, Kohashi K, Kawatoko S, Ihara E, Oki E, Nakamura M, Ogawa Y, Oda Y: Tumor progression by epithelial-mesenchymal transition in arid1a- and smarca4-aberrant solid-type poorly differentiated gastric adenocarcinoma. Virchows Arch 480(5): 1063-1075, 2022
Ohkubo A, Osoegawa T, Harada N, Iboshi Y, Sumida Y, Nakamuta M, Suematsu E, Kobayashi H, Ihara E: A rare case of rheumatoid arthritis with tocilizumab-induced intestinal mucosal injury. Intern Med 61(7): 1011-1014, 2022
Minoda Y, Ogino H, Sumida Y, Osoegawa T, Itaba S, Hashimoto N, Esaki M, Kitagawa Y, Yodoe K, Iboshi Y, Matsuguchi T, Tadokoro M, Chaen T, Kubo H, Kubokawa M, Harada N, Nishizima K, Fujii H, Hata Y, Tanaka Y, Ihara E, Ogawa Y: Is a small-caliber or large-caliber endoscope more suitable for colonic self-expandable metallic stent placement? A randomized controlled study. Therap Adv Gastroenterol 1517562848211065331, 2022
Minoda Y, Ihara E, Itaba S, Sumida Y, Haraguchi K, Aso A, Mizutani T, Osoegawa T, Esaki M, Nagatomo S, Nishioka K, Muta K, Bai X, Ogino H, Fujimori N, Tsurumaru D, Ohuchida K, Qingjiang H, Oki E, Yamamoto H, Ogawa Y: Negligible procedure-related dissemination risk of mucosal incision-assisted biopsy for gastrointestinal stromal tumors versus endoscopic ultrasound-guided fine-needle aspiration/biopsy. Surg Endosc 2022
Minoda Y, Ihara E, Fujimori N, Nagatomo S, Esaki M, Hata Y, Bai X, Tanaka Y, Ogino H, Chinen T, Hu Q, Oki E, Yamamoto H, Ogawa Y: Efficacy of ultrasound endoscopy with artificial intelligence for the differential diagnosis of non-gastric gastrointestinal stromal tumors. Sci Rep 12(1): 16640, 2022
Minoda Y, Esaki M, Ihara E, Nagatomo S, Nishioka K, Fujimori N, Ogino H, Bai X, Tanaka Y, Chinen T, Hu Q, Ota M, Umekita S, Yamamoto H, Ogawa Y: Auxiliary diagnosis of subepithelial lesions by impedance measurement during endoscopic ultrasound guided fine-needle biopsy. Gastrointest Endosc 2022
Matsumoto K, Fujimori N, Hata Y, Minoda Y, Murakami M, Teramatsu K, Takamatsu Y, Takeno A, Oono T, Ihara E, Nakata K, Nakamura M, Yamamoto T, Koga Y, Oda Y, Ito T, Ogawa Y: Ampullary neuroendocrine neoplasm: Clinicopathological characteristics and novel endoscopic entity. Dig Dis 2022
Iwakiri K, Fujiwara Y, Manabe N, Ihara E, Kuribayashi S, Akiyama J, Kondo T, Yamashita H, Ishimura N, Kitasako Y, Iijima K, Koike T, Omura N, Nomura T, Kawamura O, Ohara S, Ozawa S, Kinoshita Y, Mochida S, Enomoto N, Shimosegawa T, Koike K: Evidence-based clinical practice guidelines for gastroesophageal reflux disease 2021. J Gastroenterol 57(4): 267-285, 2022
Ihara E, Ogino H, Muta K, Hamada S, Wada M, Hata Y, Ikeda H, Bai X, Minoda Y, Esaki M, Tanaka Y, Chinen T, Ogawa Y: The treatment effects of acotiamide in esophagogastric outflow obstruction: A prospective longitudinal observational study. Esophagus 19(2): 332-342, 2022
Iboshi Y, Sumida Y, Ihara E, Fujii H, Harada N, Nakamuta M, Ogawa Y: Over-the-catheter endoscope replacement for stenting in patients with inaccessible malignant colonic obstruction with coexisting peritoneal carcinomatosis. Dig Endosc 2022
Hata Y, Ihara E, Wada M, Tsuru H, Muta K, Minoda Y, Bai X, Esaki M, Tanaka Y, Chinen T, Ogino H, Sakamoto R, Ogawa Y: Improved esophagography screening for esophageal motility disorders using wave appearance and supra-junctional ballooning. J Gastroenterol 57(11): 838-847, 2022
Hamada S, Ihara E, Yoshitake C, Inada T, Fukuya H, Ohkubo A, Tomoeda N, Iboshi Y, Sumida Y, Yoshimura D, Nakamuta M, Harada N: Clip stopper closure method using a detachable snare in combination with zeoclip for endoscopic submucosal dissection-induced mucosal defects. Dig Endosc 2022
Hamada S, Ihara E, Muta K, Wada M, Hata Y, Ikeda H, Tanaka Y, Ogino H, Chinen T, Ogawa Y: Onigiri esophagography as a screening test for esophageal motility disorders. J Neurogastroenterol Motil 28(1): 43-52, 2022
Fukuda S, Ichida K, Kitagawa Y, Nakano K, Chaen T, Yoshimura D, Ochiai T, Ihara E, Ogawa Y: An adult case of congenital duodenal diaphragm that was successfully treated by endoscopic resection using a grasping-type scissor forceps. DEN Open 2e93, 2022
Esaki M, Yamakawa S, Ichijima R, Suzuki S, Kusano C, Ikehara H, Minoda Y, Ihara E, Gotoda T: Self-completion method of endoscopic submucosal dissection using the endosaber for treating colorectal neoplasms (with video). Sci Rep 12(1): 5821, 2022
Esaki M, Minoda Y, Ihara E: In living color: Linked color imaging for the detection of early gastric cancer. Dig Dis Sci 67(6): 1922-1924, 2022
Esaki M, Maehara R, Nagatomo S, Nishioka K, Minoda Y, Ogino H, Ihara E: Application of traction-method to hybrid endoscopic submucosal dissection for gastrointestinal tumors. Endoscopy 54(4): E160-E161, 2022
Esaki M, Ihara E, Sumida Y, Fujii H, Takahashi S, Haraguchi K, Iwasa T, Somada S, Minoda Y, Ogino H, Tagawa K, Ogawa Y: Hybrid- and conventional endoscopic submucosal dissection for early gastric neoplasms: A multi-center randomized controlled trial. Clin Gastroenterol Hepatol 2022
Esaki M, Ihara E, Fujii H, Sumida Y, Haraguchi K, Takahashi S, Iwasa T, Nakano K, Wada M, Somada S, Minoda Y, Ogino H, Tagawa K, Ogawa Y: Comparison of the procedure time differences between hybrid endoscopic submucosal dissection and conventional endoscopic submucosal dissection in patients with early gastric neoplasms: A study protocol for a multi-center randomized controlled trial (hybrid-g trial). Trials 23(1): 166, 2022
Esaki M, Ihara E, Esaki M, Nishioka K, Kimura Y, Hata Y, Tsuru H, Wada M, Minoda Y, Bai X, Shoguchi Y, Nasu T, Nagatomo S, Muta K, Ogino H, Ogawa Y: Comparisons of outcomes between proknife injection endoscopic submucosal dissection and conventional endoscopic submucosal dissection for large gastric lesions in ex vivo porcine model study: A randomized controlled trial. DEN open 2(1): e91, 2022
Otsuka Y, Bai X, Tanaka Y, Ihara E, Chinen T, Ogino H, Ogawa Y: Involvement of interstitial cells of cajal in nicotinic acetylcholine receptor-induced relaxation of the porcine lower esophageal sphincter. Eur J Pharmacol 910174491, 2021
Okuno H, Ogino H, Ihara E, Nishioka K, Tanaka Y, Chinen T, Kohjima M, Oono T, Tanaka M, Goya T, Fujimori N, Iboshi Y, Gotoda T, Ogawa Y: Discriminant equation using mucosally expressed cytokines and transcription factor for making definite diagnosis of inflammatory bowel disease unclassified. BMC Gastroenterol 21(1): 73, 2021
Okuno H, Ogino H, Ihara E, Nishioka K, Iboshi Y, Chinen T, Ochiai T, Akiho H, Nakamura K, Gotoda T, Ogawa Y: Interleukin-1beta as a predictor of glucocorticoid response in ulcerative colitis. Digestion 102(3): 357-367, 2021
Ogino H, Fukaura K, Iboshi Y, Nagamatsu Y, Okuno H, Nishioka K, Nishihara Y, Tanaka Y, Chinen T, Ihara E, Ogawa Y: Role of the il-23-t-bet/gata3 axis for the pathogenesis of ulcerative colitis. Inflammation 44(2): 592-603, 2021
Nishioka K, Ogino H, Chinen T, Ihara E, Tanaka Y, Nakamura K, Ogawa Y: Mucosal il23a expression predicts the response to ustekinumab in inflammatory bowel disease. J Gastroenterol 56(11): 976-987, 2021
Nishihara Y, Ogino H, Tanaka M, Ihara E, Fukaura K, Nishioka K, Chinen T, Tanaka Y, Nakayama J, Kang D, Ogawa Y: Mucosa-associated gut microbiota reflects clinical course of ulcerative colitis. Sci Rep 11(1): 13743, 2021
Nasu T, Esaki M, Shoguchi Y, Bai X, Minoda Y, Ogino H, Ihara E: Traction-assisted hybrid endoscopic submucosal dissection for small rectal neuroendocrine tumors. Endoscopy 2021
Nakane S, Mukaino A, Ihara E, Ogawa Y: Autoimmune gastrointestinal dysmotility: The interface between clinical immunology and neurogastroenterology. Immunol Med 44(2): 74-85, 2021
Nagatomo S, Minoda Y, Ihara E: Double scope recovery technique to manage procedure-related trouble during wire trimming with a loop cutter. Dig Endosc 33(4): e83-e84, 2021
Muta K, Ihara E, Hamada S, Ikeda H, Wada M, Hata Y, Bai X, Nishihara Y, Tanaka Y, Ogino H, Ogawa Y: Physiological and pathological roles of the accommodation response in lower esophageal sphincter relaxation during wet swallows. Sci Rep 11(1): 7898, 2021
Minoda Y, Hisamatsu Y, Ihara E: Usefulness of preoperative site marking with an indocyanine green fluorescent clip for gastrointestinal stromal tumor. Dig Endosc 33(5): e95-e96, 2021
Hamada S, Ihara E, Ikeda H, Muta K, Ogino H, Chinen T, Tanaka Y, Ogawa Y: Clinical characterization of vonoprazan-refractory gastroesophageal reflux disease. Digestion 102(2): 197-204, 2021
Fujimori N, Osoegawa T, Aso A, Itaba S, Minoda Y, Murakami M, Matsumoto K, Teramatsu K, Takamatsu Y, Takaoka T, Oono T, Ihara E, Yoshizumi T, Ohtsuka T, Nakamura M, Ogawa Y: Efficacy of early endoscopic ultrasound-guided transluminal drainage for postoperative pancreatic fistula. Can J Gastroenterol Hepatol 20216691705, 2021
Esaki M, Minoda Y, Wada M, Sakisaka S, Tsuruta S, Hosokawa T, Matsuguchi T, Ichijima R, Suzuki S, Tamura Y, Iwao A, Yamakawa S, Irie A, Ihara E, Ogawa Y: Self-completion method of endoscopic submucosal dissection using endosaber without any other device or assistance: An ex vivo porcine model study. Digestion 102(2): 139-146, 2021
Esaki M, Ihara E, Hashimoto N, Abe S, Aratono C, Shiga N, Sumida Y, Fujii H, Haraguchi K, Takahashi S, Iwasa T, Nakano K, Wada M, Somada S, Nishioka K, Minoda Y, Ogino H, Ogawa Y: Efficacy of hybrid endoscopic submucosal dissection with souten in gastric lesions: An ex vivo porcine model basic study. World J Gastrointest Surg 13(6): 563-573, 2021
Esaki M, Ihara E, Gotoda T: Endoscopic instruments and techniques in endoscopic submucosal dissection for early gastric cancer. Expert Rev Gastroenterol Hepatol 15(9): 1009-1020, 2021
Esaki M, Horii T, Ichijima R, Wada M, Sakisaka S, Abe S, Tomoeda N, Kitagawa Y, Nishioka K, Minoda Y, Tsuruta S, Suzuki S, Akiho H, Ihara E, Ogawa Y, Gotoda T: Assistant skill in gastric endoscopic submucosal dissection using a clutch cutter. World J Gastrointest Surg 13(2): 116-126, 2021
Esaki M, Esaki M, Maehara K, Minoda Y, Ogino H, Ihara E, Ogawa Y: Rubber band-assisted, one-person-operated cold snare polypectomy for colorectal polyps. Endosc Int Open 9(11): E1845-E1846, 2021
Tsuruta S, Kohashi K, Yamada Y, Fujiwara M, Koga Y, Ihara E, Ogawa Y, Oki E, Nakamura M, Oda Y: Solid-type poorly differentiated adenocarcinoma of the stomach: Deficiency of mismatch repair and swi/snf complex. Cancer Sci 111(3): 1008-1019, 2020
Oyama K, Ohuchida K, Shindo K, Moriyama T, Hata Y, Wada M, Ihara E, Nagai S, Ohtsuka T, Nakamura M: Thoracoscopic surgery combined with endoscopic creation of a submucosal tunnel for a large complicated esophageal leiomyoma. Surg Case Rep 6(1): 92, 2020
Minoda Y, Ihara E, Ogino H, Komori K, Otsuka Y, Ikeda H, Esaki M, Chinen T, Matsuguchi T, Takahashi S, Shiga N, Yoshimura R, Ogawa Y: The efficacy and safety of a promising single-channel endoscopic closure technique for endoscopic treatment-related artificial ulcers: A pilot study. Gastrointest Tumors 7(1-2): 21-29, 2020
Minoda Y, Ihara E, Komori K, Ogino H, Otsuka Y, Chinen T, Tsuda Y, Ando K, Yamamoto H, Ogawa Y: Efficacy of endoscopic ultrasound with artificial intelligence for the diagnosis of gastrointestinal stromal tumors. J Gastroenterol 55(12): 1119-1126, 2020
Minoda Y, Chinen T, Osoegawa T, Itaba S, Haraguchi K, Akiho H, Aso A, Sumida Y, Komori K, Ogino H, Ihara E, Ogawa Y: Superiority of mucosal incision-assisted biopsy over ultrasound-guided fine needle aspiration biopsy in diagnosing small gastric subepithelial lesions: A propensity score matching analysis. BMC Gastroenterol 20(1): 19, 2020
Harada N, Hirowatari M, Ihara E, Ishihara E, Inoue M, Miyamura T, Nakamuta M: A case of suspicious allergic reaction to peracetic acid following endoscopy. Clin Endosc 53(6): 743-745, 2020
Fujimori N, Minoda Y, Murakami M, Suehiro Y, Oono T, Ihara E, Ogawa Y: Endoscopic removal of a lumen-apposing metal stent that migrated into the walled-off necrosis during the first drainage procedure. Endoscopy 52(2): E51-E52, 2020
Esaki M, Minoda Y, Ihara E, Sakisaka S, Tsuruta S, Hosokawa T, Wada M, Hata Y, Suzuki S, Iwao A, Yamakawa S, Irie A, Akiho H, Ogawa Y: Efficacy of traction, using a clip-with-thread, for esophageal endoscopic submucosal dissection for esophageal lesions with fibrosis in an ex vivo pig training model. Turk J Gastroenterol 31(1): 58-64, 2020
Esaki M, Hayashi Y, Ikehara H, Ihara E, Horii T, Tamura Y, Ichijima R, Yamakawa S, Irie A, Shibuya H, Suzuki S, Kusano C, Minoda Y, Akiho H, Ogawa Y, Gotoda T: The effect of scissor-type versus non-scissor-type knives on the technical outcomes in endoscopic submucosal dissection for superficial esophageal cancer: A multi-center retrospective study. Dis Esophagus 33(4): 2020
Esaki M, Haraguchi K, Akahoshi K, Tomoeda N, Aso A, Itaba S, Ogino H, Kitagawa Y, Fujii H, Nakamura K, Kubokawa M, Harada N, Minoda Y, Suzuki S, Ihara E, Ogawa Y: Endoscopic mucosal resection vs endoscopic submucosal dissection for superficial non-ampullary duodenal tumors. World J Gastrointest Oncol 12(8): 918-930, 2020
Tsuruta S, Ohishi Y, Fujiwara M, Ihara E, Ogawa Y, Oki E, Nakamura M, Oda Y: Gastric hepatoid adenocarcinomas are a genetically heterogenous group; most tumors show chromosomal instability, but msi tumors do exist. Hum Pathol 8827-38, 2019
Osoegawa T, Minoda Y, Ihara E, Komori K, Aso A, Goto A, Itaba S, Ogino H, Nakamura K, Harada N, Makihara K, Tsuruta S, Yamamoto H, Ogawa Y: Mucosal incision-assisted biopsy versus endoscopic ultrasound-guided fine-needle aspiration with a rapid on-site evaluation for gastric subepithelial lesions: A randomized cross-over study. Dig Endosc 31(4): 413-421, 2019
Minoda Y, Ogino H, Chinen T, Ihara E, Haraguchi K, Akiho H, Takizawa N, Aso A, Tomita Y, Esaki M, Komori K, Otsuka Y, Iwasa T, Ogawa Y: Objective validity of the japan narrow-band imaging expert team classification system for the differential diagnosis of colorectal polyps. Dig Endosc 31(5): 544-551, 2019
Minoda Y, Fujimori N, Ihara E: Forward-viewing endoscopic ultrasound-guided fine-needle biopsy using the clip-with-thread method for small gastric subepithelial lesions. Dig Endosc 31(6): e103-e104, 2019
Komori K, Ihara E, Minoda Y, Ogino H, Sasaki T, Fujiwara M, Oda Y, Ogawa Y: The altered mucosal barrier function in the duodenum plays a role in the pathogenesis of functional dyspepsia. Dig Dis Sci 64(11): 3228-3239, 2019
Fukaura K, Iboshi Y, Ogino H, Ihara E, Nakamura K, Nishihara Y, Nishioka K, Chinen T, Iwasa T, Aso A, Goto A, Haraguchi K, Akiho H, Harada N, Ogawa Y: Mucosal profiles of immune molecules related to t helper and regulatory t cells predict future relapse in patients with quiescent ulcerative colitis. Inflamm Bowel Dis 25(6): 1019-1027, 2019
Bai X, Ihara E, Otsuka Y, Tsuruta S, Hirano K, Tanaka Y, Ogino H, Hirano M, Chinen T, Akiho H, Nakamura K, Oda Y, Ogawa Y: Involvement of different receptor subtypes in prostaglandin e2-induced contraction and relaxation in the lower esophageal sphincter and esophageal body. Eur J Pharmacol 857172405, 2019
H. Hayashi, M. Esaki, S. Suzuki, T. Hosokawa, Y. Tanaka, T. Mizutani, S. Tsuruta, A. Iwao, S. Yamakawa, A. Irie, Y. Minoda, Y. Hata, H. Ogino, H. Akiho, E. Ihara, Y. Ogawa. The efficacy of scissor-type knife in endoscopic submucosal dissection for early gastric neoplasms: a propensity score matching analysis. World Journal of Gastrointestinal Oncology. 10:487-495,2018
Campbell C, Dikiy S, Bhattarai SK, Chinen T, Matheis F, Calafiore M, Hoyos B, Hanash A, Mucida D, Bucci V, Rudensky AY. Extrathymically Generated Regulatory T Cells Establish a Niche for Intestinal Border-Dwelling Bacteria and Affect Physiologic Metabolite Balance. Immunity. 48:1245-1257,2018
M. Esaki, S. Suzuki, Y. Hayashi, A. Yokoyama, S. Abe, T. Hosokawa, S. Tsuruta, Y. Minoda, Y. Hata, H. Ogino, H. Akiho, E. Ihara and Y. Ogawa. Propensity score-matching analysis to compare clinical outcomes of endoscopic submucosal dissection for early gastric cancer in the postoperative and non-operative stomachs. BMC Gastroenterol 18:125, 2018
A. Mukaino, H. Minami, H. Isomoto, H. Hamamoto, E. Ihara. Y. Maeda, O. Higuchi, T. Okanishi, Y. Kokudo, K. Deguchi, F. Sasaki, T. Ueki, K. Murata, T. Yoshida, M. Kinjo, Y. Ogawa, A. Ido, H. Matsuo, K. Nakao, S. Nakane. Anti-ganglionic acetylcholine receptor antibodies in Japanese patients with motility disorders. J Gastroenterol 53:1227-1240, 2018
T. Iwasa, R. Nakadate, S. Onogi, Y. Okamoto, J. Arata, S. Oguri, H. Ogino H, E. Ihara, K. Ohuchida, T. Akahoshi, T. Ikeda, Y. Ogawa, M. Hashizume. A new robotic-assisted flexible endoscope with single-hand control: endoscopic submucosal dissection in the ex vivo porcine stomach. Surgical Endoscopy 32:3386-3392, 2018
K. Fukaura, E. Ihara, H. Ogino, Y. Iboshi, K. Muta, X. Bai, S. Hamada, Y. Hata, T. Iwasa, A. Aso, K. Nakamura, Y. Ogawa. Mucosally expressed cytokines are associated with the esophageal motility function. Digestion 98:95-103, 2018
M. Esaki, S. Suzuki, Y. Hayashi, A. Yokoyama, S. Abe, T. Hosokawa, H. Ogino, H. Akiho, E. Ihara, Y. Ogawa. Splash M-knife versus Flush Knife BT in the technical outcomes of endoscopic submucosal dissection for early gastric cancer: a propensity score matching analysis. BMC Gastroenterol 18:35, 2018
K. Nakano, H. Yamamoto, M. Fujiwara, Y. Koga, S. Tsuruta, E. Ihara, E. Oki, M. Nakamura, Y. Ogawa, Y. Oda. Clinicopathogenic and molecular characteristics of synchronous colorectal carcinoma with mismatch repair deficiency. Am J Surg Pathol 42:172-182, 2018
Bai X, Ihara E, Hirano K, Tanaka Y, Nakano K, Kita S, Iwamoto T, Ogino H, Hirano M, Nakamura K, Ogawa Y. Endogenous hydrogen sulfide contributes to tone generation in porcine lower esophageal sphincter via Na+/Ca2+ exchanger. Cell Mol Gastroenterol Hepatol 5;209-221, 2017
Otsuka Y, Akahoshi K, Yasunaga K, Kubokawa M, Gibo J, Osada S, Tokumaru K, Miyamoto K, Sato T, Shiratsuchi Y, Oya M, Koga H, Ihara E and Nakamura K. Clinical outcome of Clutch Cutter endoscopic submucosal dissection for older patients with early gastric cancer. World J Gastrointest Oncol 9:416-422, 2017
Motomura Y, Akahoshi K, Kajiyama K, Gibo J, Miyamoto K, Ikeda H, Yamaguchi E, Teramatsu K, Utsunomiya R, Miyagaki A, Ooya M and Ihara E. Utility of lavage cytology plus targeted biopsy during cholangioscopy for the diagnosis of indeterminate biliary lesions. Gastroenterol Hepatol Endosc 2:1-4, 2017
Akahoshi K, Kubokawa M, Gibo J, Osada S, Tokumaru K, Yamaguchi E, Ikeda H, Sato T, Miyamoto K, Kimura Y, Shiratsuchi Y, Oya M, Koga H, Ihara E, Nakamura K. Endoscopic submucosal dissection of gastric adenoma using the clutch cutter. World J Gastrointest Endosc. 9:334-340, 2017
Komori K, Kubokawa M, Ihara E, Akahoshi K, Nakamura K, Motomura K, Masumoto A. Prognostic factors associated with mortality in patients with gastric fundal varieal bleeding World J Gastroenterol. 23:496-504, 2017
Bai X, Tanaka Y, Ihara E, Hirano K, Nakano K, Hirano M, Oda Y and Nakamura K. Trypsin induces biphasic muscle contraction and relaxation via transient receptor vanilloid 1 and neurokinin receptor 1/2 in porcine esophageal body. Eur J Pharmacol. 797:65-74, 2017
Akahoshi K, Kubokawa M, Gibo J, Osada S, Tokumaru K, Shiratsuchi Y, Oya M, Ihara E, Nakamura K. Endoscopic resection using the Clutch Cutter and a detachable snare for large pedunculated colonic polyps. Endoscopy 49:54-58, 2017
Chinen T, Kannan AK, Levine AG, Fan X, Klein U, Gasteiger G, Feng Y, Fontenot JD, Rudensky AY.An essential role for the IL-2 receptor in Treg cell function.Nat Immunol. 17:1322-1333, 2016
Tanaka Y, Ihara E, Nakamura K, Muta K, Fukaura K, Mukai K, Xiaopeng B, Takayanagi R: Clinical characteristics associated with esophageal motility function. J Gastroenterol Hepatol 31:1133-1140, 2016
Nakamura K, Ihara E, Akiho H, Akahoshi K, Harada N, Ochiai T, Nakamura N, Ogino H, Iwasa T, Aso A, Iboshi Y, Takayanagi R: Limited effects of rebamipide in addition to proton pump inhibitor (PPI) in the treatment of post-endoscopic submucosal dissection gastric ulcers: a randomized controlled trial comparing PPI plus rebamipide combination therapy with PPI monotherapy. Gut and Liver 10:917-924, 2016
Muta K, Ihara E, Fukaura K, Tsuchida O, Ochiai T, Nakamura K: Effects of acotiamide on esophageal motility function in patients with esophageal motility disorders: a pilot study. Digestion 94:9-16, 2016
Komori K, Nakamura K, Ihara E, Iwasa T, Hirahashi M, Oda Y, Takayanagi R: Endoscopic submucosal dissection is feasible for very elderly patients with early gastric cancer: comparison of short-term and long-term outcomes in very elderly and non-elderly patients. Fukuoka Acta Medica 107:72-81, 2016
Aso A, Yoshinaga S: Future potential means of diagnosing gastric subepithelial lesions: Beyond conventional endoscopic ultrasound and endoscopic ultrasound-guided fine-needle aspiration. Dig Endosc Suppl1:32-33, 2016
Nakamura K, Osada M, Goto A, Iwasa T, Takahashi S, Takizawa N, Akahoshi K, Ochiai T, Nakamura N, Akiho H, Itaba S, Harada N, Iji M, Tanaka M, Kubo H, Somada S, Ihara E, Oda Y, Ito T, Takayanagi R: Short- and long-term outcomes of endoscopic resection of rectal neuroendocrine tumors: analyses according to the WHO 2010 classification. Scand J Gastroenterol 51:448-455, 2016
Tanaka Y, Ihara E, Hirano K, Takahashi S, Hirano M, Nakamura K, Akiho H, Oda Y, Takayanagi R: Trypsin-induced biphasic regulation of tone in the porcine lower esophageal sphincter. Eur J Phamacol 752:97-105, 2015
Ihara E, Yu Q, Chappellaz M, MacDonald JA: ERK and p38MAPK pathways regulate myosin light chain phosphatase and contribute to Ca2+ sensitization of intestinal smooth muscle contraction. Neurogastroenterol Motil 27:135-146, 2015
Feng Y, Arvey A, Chinen T, van der Veeken J, Gasteiger G, Rudensky AY.Control of the inheritance of regulatory T cell identity by a cis element in the Foxp3 locus.Cell. 158:749-63, 2014
Osada M, Aishima S, Hirahashi M, Takizawa N, Takahashi S, Nakamura K, Tanaka M, Maehara Y, Takayanagi R, Oda Y: Combination of hepatocellular markers is useful for prognostication in gastric hepatoid adenocarcinoma. Human Pathology 45:1243-1250, 2014
Iboshi Y, Nakamura K, Ihara E, Iwasa T, Akiho H, Harada N, Nakamuta M, Takayanagi R: Multigene analysis unveils distinctive expression profiles of helper T cell-related genes in the intestinal mucosa that discriminate between ulcerative colitis and Crohn' disease. Inflammatory Bowel Diseases 20:967-977, 2014
Akiho H, Tokita Y, Nakamura K, Satoh K, Nishiyama M, Tsuchiya N, Tsuchiya K, Ohbuchi K, Iwakura Y, Ihara E, Takayanagi R, Yamamoto M: Involvement of interleukin-17A-induced hypercontractility of intestinal smooth muscle cells in persistent gut motor dysfunction. PLOS ONE 9:e92960, 2014
Aso A, Ihara E, Osoegawa T, Nakamura K, Itaba S, Igarashi H, Ito T, Aishima S, Oda Y, Tanaka M, Takayanagi R: Key endoscopic ultrasound features of pancreatic ductal adenocarcinoma smaller than 20 mm. Scand J Gastroenterol 49:332-338, 2014
Ihara E, Matsuzaka H, Honda K, Hata Y, Sumida Y, Akiho H, Misawa T, Toyoshima S, Chijiiwa Y, Nakamura K, Takayanagi R: Mucosal-incision assisted biopsy for suspected gastric gastrointestinal stromal tumors. World J Gastrointest Endosc 5:191-196, 2013
Akahoshi K, Minoda Y, Komori K, Motomura Y, Kubokawa M, Otsuka Y, Hamada S, Fukuda S, Iwao R, Gibo J, Oya M, Nakamura K: Endoscopic submucosal dissection using the "Clutch Cutter" for early esophageal squamous cell carcinoma. Endoscopy 45:1035-1038, 2013
Itaba S, Nakamura K, Aso A, Tokunaga S, Akiho H, Ihara E, Iboshi Y, Iwasa T, Akahoshi K, Ito T, Takayanagi R: Prospective, randomized, double-blind, placebo-controlled trial of ulinastatin for prevention of hyperenzymemia after double balloon endoscopy via the antegrade approach. Dig Endosc 25:421-427, 2013
Higuchi N, Nakamura K, Ihara E, Akahoshi K, Akiho H, Sumida Y, Motomura Y, Kubokawa M, Ito T, Takayanagi R: Preserved gastric motility in patients with early gastric cancer after endoscopic submucosal dissection. J Gastroenterol Hepatol 28:494-498, 2013
Josefowicz S, Niec R, Kim HY, Treuting P, Chinen T, Umetsu DT, Rudensky AY. Extrathymically generated regulatory T cells control mucosal Th2 inflammation. Nature. 482:395-9, 2012
Ihara E, Chappellaz M, Turner SR, MacDonald JA: The contribution of protein kinase C and CPI-17 signaling pathways to hypercontractility in murine experimental colitis. Neurogastroenterol Motil 24:e15-26, 2012
Iwasa T, Ogino H, Nakamura K, Ihara E, Akiho H, Takayanagi R: Feeding administration of Daikenchuto suppresses colitis induced by naive CD4+ T cell transfer into SCID mice. Dig Dis Sci 57:2571-2579, 2012
Somada S, Muta H, Nakamura K, Sun X, Honda K, Ihara E, Akiho H, Takayanagi R, Yoshikai Y, Podack ER, Tani K: CD30 ligand/CD30 interaction is involved in pathogenesis of inflammatory bowel disease. Dig Dis Sci 57: 2031-2037, 2012
Ogino H, Nakamura K, Iwasa T, Ihara E, Akiho H, Motomura Y, Akahoshi K, Igarashi H, Kato M, Kotoh K, Ito T, Takayanagi R: Regulatory T cells expanded by rapamycin in vitro suppress colitis in an experimental mouse model. J Gastroenterol 47: 366-376, 2012
Ihara E, Chappellaz M, Turner SR, MacDonald JA: The contribution of protein kinase C and CPI-17 signaling pathways to hypercontractility in murine experimental colitis. Neurogastroenterol Motil 24:e15-26, 2012
Chinen T, Komai K, Muto G, Morita R, Inoue N, Yoshida H, Sekiya T, Nakamura K, Yoshimura A. Prostaglandin E2 and SOCS1 have a role in intestinal immune tolerance. Nat Commun. 2:190, 2011
Takahashi R, Nishimoto S, Muto G, Sekiya T, Tamiya T, Kimura A, Morita R, Chinen T, Yoshimura A. SOCS1 is essential for Treg cell functions by preventing loss of Foxp3 expression as well as IFN-g and IL-17A production. J Exp Med. 208:2055-67, 2011
Itaba S, Iboshi Y, Nakamura K, Ogino H, Sumida Y, Aso A, Yoshinaga S, Akiho H, Igarashi H, Kato M, Kotoh K, Ito T, Takayanagi R: Low-frequency of bacteremia after endoscopic submucosal dissection of the stomach. Dig Endosc 23: 69-72, 2011
Goto A, Hirahashi M, Osada M, Nakamura K, Yao T, Tsuneyoshi M, Takayanagi R, Oda Y:
Aberrant activation-induced cytidine deaminase expression is associated with mucosal intestinalization in the early stage of gastric cancer. Virchows Arch 458: 717-724, 2011
Kanayama K, Nakamura K, Ogino H, Sumida Y, Ihara E, Akiho H, Takayanagi R: Th1 responses are more susceptible to infliximab-mediated immunosuppression than Th17 responses. Dig Dis Sci 56: 3525-3533, 2011
Ogino H, Nakamura K, Iwasa T, Ihara E, Akiho H, Motomura Y, Akahoshi K, Igarashi H, Kato M, Kotoh K, Ito T, Takayanagi R: Regulatory T Cells expanded by rapamycin in vitro suppress colitis in an experimental mouse model. J Gastroenterol 47: 366-376, 2012
Akiho H, Nakamura K: Daikenchuto ameliorated muscle hypercontractility in a murine T-cell-mediated persistent gut motor dysfunction model. Digestion 83: 173-179, 2011
Ogino H, Nakamura K, Ihara E, Akiho H, Takayanagi R: CD4+CD25+ regulatory T cells suppress Th17-responses in an experimental colitis model. Dig Dis Sci 56: 376-386, 2011
Iwasa T, Nakamura K, Ogino H, Itaba S, Akiho H, Okamoto R, Iboshi Y, Aso A, Murao H, Kanayama K, Ito T, Takayanagi R: Multiple ulcers in the small and large intestines occurred during tocilizumab therapy for rheumatoid arthritis. Endoscopy 43: 70-72, 2011
Akahoshi K, Honda K, Motomura Y, Kubokawa M, Okamoto R, Osoegawa T, Nakama N, Kashiwabara Y, Higuchi N, Tanaka Y, Oya M, Nakamura K: Endoscopic submucosal dissection using a grasping-type scissors forceps for early gastric cancers and adenomas. Dig Endosc 23: 24-29, 2011
Chinen T, Volchkov PY, Chervonsky AV, Rudensky AY. A critical role for regulatory T cell-mediated control of inflammation in the absence of commensal microbiota. J Exp Med. 207:2323-30, 2010
Mizutani T, Akiho H, Khan WI, Murao H, Ogino H, Kanayama K, Nakamura K, Takayanagi R: Persistent gut motor dysfunction in a murine model of T-cell-induced enteropathy. Neurogastroenterol Motil 22: 196-203, 2010
Yoshinaga M, Kitamura Y, Chaen T, Yamashita S, Tsuruta S, Hisano T, Ikeda Y, Sakai H, Nakamura K, Takayanagi R, Muto Y: The simultaneous expression of peroxisome proliferator-activated receptor delta and cyclooxygenase-2 may enhance angiogenesis and tumor venous invasion in tissues of colorectal cancers. Dig Dis Sci 54: 1108-1114, 2009
Higuchi N, Sumida Y, Nakamura K, Itaba S, Yoshinaga S, Mizutani T, Honda K, Taki K, Murao H, Ogino H, Kanayama K, Akiho H, Goto A, Segawa Y, Yao T, Takayanagi R: Impact of double-balloon endoscopy on the diagnosis of jejunoileal involvement in primary intestinal follicular lymphomas: a case series. Endoscopy 41: 175-178, 2009
Kubo H, Nakamura K, Itaba S, Yoshinaga S, Kinukawa N, Sadamoto Y, Ito T, Yonemasu H, Takayanagi R: Differential diagnosis of cystic tumors of the pancreas by endoscopic ultrasonography. Endoscopy 41: 684-689, 2009
Ihara E, Moffat L, Borman MA, Amon JE, Walsh MP, MacDonald JA: Ca2+-independent contraction of longitudinal ileal smooth muscle is potentiated by a zipper-interacting protein kinase pseudosubstrate peptide. Am J Physiol Gastrointest Liver Physiol 297: G361-370, 2009
Ichiyama K, Yoshida H, Wakabayashi Y, Chinen T, Saeki K, Takaesu G, Hori S, Yoshimura A, Kobayashi T. Foxp3 inhibits RORgt-mediated IL-17A mRNA transcription through direct interaction with RORgt. J Biol Chem. 283:17003-8, 2008
Sumida Y, Nakamura K, Kanayama K, Akiho H, Teshima T, Takayanagi R: Preparation of functionally preserved CD4+CD25high regulatory T cells from leukapheresis products from ulcerative colitis patients, applicable to regulatory T-cell-transfer therapy. Cytotherapy 10: 698-710, 2008
Motomura Y, Ghia J-E, Wang H, Akiho H, El-Sharkawy RT, Collins M, Wan Y, McLaughlin JT, Khan WI: Enterochromaffin cell and 5-hydroxytryptamine responses to the same infectious agent differ in Th1 and Th2 dominant environments. Gut 57:475-481, 2008
Sun X, Somada S, Shibata K, Muta H, Yamada H, Yoshihara H, Honda K, Nakamura K, Takayanagi R, Tani K, Podack ER, Yoshikai Y: A critical role of CD30 ligand/CD30 in controlling inflammatory bowel diseases in mice. Gastroenterology 134: 447-58, 2008
Yoshinaga S, Gotoda T, Kusano C, Oda I, Nakamura K, Takayanagi R: Clinical impact of endoscopic submucosal dissection for superficial adenocarcinoma located at the esophagogastric junction. Gastrointest Endosc 67: 202-9, 2008
