研究室紹介
Our Laboratories
研究室紹介
Our Laboratories
合谷 孟 業績
原著論文
Imoto K, Tanaka M, Goya T, Azuma Y, Hioki T, Morita Y, Sakaguchi K, Fujita N, Kakino T, Ishikita A, Yamamura K, Sakamoto I, Ishigami K, Abe K, Ogawa Y.
Cisterna Chyli Dilation Is a Risk Factor for Liver Nodules and Hepatocellular Carcinoma in Fontan-Associated Liver Disease: Pathophysiological Role of Lymphatic Dysfunction
Hepatol Res. 2026 Sep 12. doi: 10.1111/hepr.70268. Online ahead of print.
Aoyagi T, Goya T, Imoto K, Azuma Y, Hioki T, Kohjima M, Tanaka M, Oda Y, Ogawa Y.
Two types of regenerative cell populations appear in acute liver injury.
Stem Cell Reports. 20(4):102503, 2025.
Imoto K, Goya T, Azuma Y, Hioki T, Aoyagi T, Nagata H, Nishizaki A, Kakino T, Ishikita A, Yamamura K, Sakamoto I, Tanaka M, Abe K, Ogawa Y.
Strain elastography for detecting advanced Fontan-associated liver disease: a retrospective study.
BMC Gastroenterol. 25:341, 2025.
Hioki T, Imoto K, Goya T, Azuma Y, Horiuchi A, Aoyagi T, Takahashi M, Oda Y, Kato M, Kohjima M, Tanaka M, Ogawa Y.
Clinicopathological features of steroid-refractory immune-mediated hepatotoxicity induced by immune checkpoint inhibitors.
BMC Gastroenterol. 26(1):49, 2025.
Yoshimura R, Tanaka M, Kurokawa M, Nakamura N, Goya T, Imoto K, Kohjima M, Fujiu K, Iwami S, Ogawa Y.
Stratifying and predicting progression to acute liver failure during the early phase of acute liver injury
PNAS Nexus. 4(2):pgaf004. 2025.
Kurokawa M, Goya T, Kohjima M, Tanaka M, Iwabuchi S, Shichino S, Ueha S, Hioki T, Aoyagi T, Takahashi M, Imoto K, Tashiro S, Suzuki H, Kato M, Hashimoto S, Matsuda H, Matsushima K, Ogawa Y.
Microcirculatory disturbance in acute liver injury is triggered by IFNγ-CD40 axis.
J inflamm(Lond). 21(1):23, 2024.
Imoto K, Tanaka M, Goya T, Azuma Y, Hioki T, Aoyagi T, Takahashi M, Kurokawa M, Kato M, Kohjima M, Ogawa Y.
Acute kidney injury is an unfavorable prognostic factor in acute liver failure and is associated with tumor necrosis factor-alpha
Medicine (Baltimore). 102(45):e35931. 2023.
Fujinuma S, Nakatsumi H, Shimizu H, Sugiyama S, Harada A, Goya T, Tanaka M, Kohjima M, Takahashi M, Izumi Y, Yagi M, Kang D, Kaneko M, Shigeta M, Bamba T, Ohkawa Y, Nakayama KI.
FOXK1 promotes nonalcoholic fatty liver disease by mediating mTORC1-dependent inhibition of hepatic fatty acid oxidation
Cell Rep. 42(5):112530. 2023.
Kuwano A, Okui T, Kohjima M, Kurokawa M, Goya T, Tanaka M, Aoyagi T, Takahashi M, Imoto K, Tashiro S, Suzuki H, Fujita N, Ushijima Y, Ishigami K, Tokunaga S, Kato M, Ogawa Y.
Transcatheter arterial steroid injection therapy improves the prognosis of patients with acute liver failure
Medicine (Baltimore). 102(10):e33090. 2023.
Goya T, Horisawa K, Udono M, Ohkawa Y, Ogawa Y, Sekiya S, Suzuki A.
Direct Conversion of Human Endothelial Cells Into Liver Cancer-Forming Cells Using Nonintegrative Episomal Vectors
Hepatol Commun. 6(7):1725-1740. 2022.
Imoto K, Tanaka M, Goya T, Aoyagi T, Takahashi M, Kurokawa M, Tashiro S, Kato M, Kohjima M, Ogawa Y.
Corticosteroid suppresses urea-cycle-related gene expressions in ornithine transcarbamylase deficiency
MC Gastroenterol. 22(1):144. 2022.
Tashiro S, Tanaka M, Goya T, Aoyagi T, Kurokawa M, Imoto K, Kuwano A, Takahashi M, Suzuki H, Kohjima M, Kato M, Ogawa Y.
Pirfenidone attenuates acetaminophen-induced liver injury via suppressing c-Jun N-terminal kinase phosphorylation
Toxicol Appl Pharmacol. 434:115817. 2022.
Suzuki H, Kohjima M, Tanaka M, Goya T, Itoh S, Yoshizumi T, Mori M, Tsuda M, Takahashi M, Kurokawa M, Imoto K, Tashiro S, Kuwano A, Kato M, Okada S, Nakamuta M, Ogawa Y.
Metabolic Alteration in Hepatocellular Carcinoma: Mechanism of Lipid Accumulation in Well-Differentiated Hepatocellular Carcinoma
Can J Gastroenterol Hepatol. 2021:8813410. 2021.
Kuwano A, Tanaka M, Suzuki H, Kurokawa M, Imoto K, Tashiro S, Goya T, Kohjima M, Kato M, Ogawa Y.
Upregulated expression of hypoxia reactive genes in peripheral blood mononuclear cells from chronic liver disease patients
Biochem Biophys Rep. 27:101068. 2021.
Inada H, Udono M, Matsuda-Ito K, Horisawa K, Ohkawa Y, Miura S, Goya T, Yamamoto J, Nagasaki M, Ueno K, Saitou D, Suyama M, Maehara Y, Kumamaru W, Ogawa Y, Sekiya S, Suzuki A.
Direct reprogramming of human umbilical vein- and peripheral blood-derived endothelial cells into hepatic progenitor cells
Nat Commun. 11(1):5292. 2020.
Miyazaki M, Yada M, Tanaka K, Senjyu T, Goya T, Motomura K, Kohjima M, Kato M, Masumoto A, Kotoh K.
Efficacy of tolvaptan for the patients with advanced hepatocellular carcinoma
World J Gastroenterol. 23(29):5379-5385. 2017.
Cisterna Chyli Dilation Is a Risk Factor for Liver Nodules and Hepatocellular Carcinoma in Fontan-Associated Liver Disease: Pathophysiological Role of Lymphatic Dysfunction
Hepatol Res. 2026 Sep 12. doi: 10.1111/hepr.70268. Online ahead of print.
Aoyagi T, Goya T, Imoto K, Azuma Y, Hioki T, Kohjima M, Tanaka M, Oda Y, Ogawa Y.
Two types of regenerative cell populations appear in acute liver injury.
Stem Cell Reports. 20(4):102503, 2025.
Imoto K, Goya T, Azuma Y, Hioki T, Aoyagi T, Nagata H, Nishizaki A, Kakino T, Ishikita A, Yamamura K, Sakamoto I, Tanaka M, Abe K, Ogawa Y.
Strain elastography for detecting advanced Fontan-associated liver disease: a retrospective study.
BMC Gastroenterol. 25:341, 2025.
Hioki T, Imoto K, Goya T, Azuma Y, Horiuchi A, Aoyagi T, Takahashi M, Oda Y, Kato M, Kohjima M, Tanaka M, Ogawa Y.
Clinicopathological features of steroid-refractory immune-mediated hepatotoxicity induced by immune checkpoint inhibitors.
BMC Gastroenterol. 26(1):49, 2025.
Yoshimura R, Tanaka M, Kurokawa M, Nakamura N, Goya T, Imoto K, Kohjima M, Fujiu K, Iwami S, Ogawa Y.
Stratifying and predicting progression to acute liver failure during the early phase of acute liver injury
PNAS Nexus. 4(2):pgaf004. 2025.
Kurokawa M, Goya T, Kohjima M, Tanaka M, Iwabuchi S, Shichino S, Ueha S, Hioki T, Aoyagi T, Takahashi M, Imoto K, Tashiro S, Suzuki H, Kato M, Hashimoto S, Matsuda H, Matsushima K, Ogawa Y.
Microcirculatory disturbance in acute liver injury is triggered by IFNγ-CD40 axis.
J inflamm(Lond). 21(1):23, 2024.
Imoto K, Tanaka M, Goya T, Azuma Y, Hioki T, Aoyagi T, Takahashi M, Kurokawa M, Kato M, Kohjima M, Ogawa Y.
Acute kidney injury is an unfavorable prognostic factor in acute liver failure and is associated with tumor necrosis factor-alpha
Medicine (Baltimore). 102(45):e35931. 2023.
Fujinuma S, Nakatsumi H, Shimizu H, Sugiyama S, Harada A, Goya T, Tanaka M, Kohjima M, Takahashi M, Izumi Y, Yagi M, Kang D, Kaneko M, Shigeta M, Bamba T, Ohkawa Y, Nakayama KI.
FOXK1 promotes nonalcoholic fatty liver disease by mediating mTORC1-dependent inhibition of hepatic fatty acid oxidation
Cell Rep. 42(5):112530. 2023.
Kuwano A, Okui T, Kohjima M, Kurokawa M, Goya T, Tanaka M, Aoyagi T, Takahashi M, Imoto K, Tashiro S, Suzuki H, Fujita N, Ushijima Y, Ishigami K, Tokunaga S, Kato M, Ogawa Y.
Transcatheter arterial steroid injection therapy improves the prognosis of patients with acute liver failure
Medicine (Baltimore). 102(10):e33090. 2023.
Goya T, Horisawa K, Udono M, Ohkawa Y, Ogawa Y, Sekiya S, Suzuki A.
Direct Conversion of Human Endothelial Cells Into Liver Cancer-Forming Cells Using Nonintegrative Episomal Vectors
Hepatol Commun. 6(7):1725-1740. 2022.
Imoto K, Tanaka M, Goya T, Aoyagi T, Takahashi M, Kurokawa M, Tashiro S, Kato M, Kohjima M, Ogawa Y.
Corticosteroid suppresses urea-cycle-related gene expressions in ornithine transcarbamylase deficiency
MC Gastroenterol. 22(1):144. 2022.
Tashiro S, Tanaka M, Goya T, Aoyagi T, Kurokawa M, Imoto K, Kuwano A, Takahashi M, Suzuki H, Kohjima M, Kato M, Ogawa Y.
Pirfenidone attenuates acetaminophen-induced liver injury via suppressing c-Jun N-terminal kinase phosphorylation
Toxicol Appl Pharmacol. 434:115817. 2022.
Suzuki H, Kohjima M, Tanaka M, Goya T, Itoh S, Yoshizumi T, Mori M, Tsuda M, Takahashi M, Kurokawa M, Imoto K, Tashiro S, Kuwano A, Kato M, Okada S, Nakamuta M, Ogawa Y.
Metabolic Alteration in Hepatocellular Carcinoma: Mechanism of Lipid Accumulation in Well-Differentiated Hepatocellular Carcinoma
Can J Gastroenterol Hepatol. 2021:8813410. 2021.
Kuwano A, Tanaka M, Suzuki H, Kurokawa M, Imoto K, Tashiro S, Goya T, Kohjima M, Kato M, Ogawa Y.
Upregulated expression of hypoxia reactive genes in peripheral blood mononuclear cells from chronic liver disease patients
Biochem Biophys Rep. 27:101068. 2021.
Inada H, Udono M, Matsuda-Ito K, Horisawa K, Ohkawa Y, Miura S, Goya T, Yamamoto J, Nagasaki M, Ueno K, Saitou D, Suyama M, Maehara Y, Kumamaru W, Ogawa Y, Sekiya S, Suzuki A.
Direct reprogramming of human umbilical vein- and peripheral blood-derived endothelial cells into hepatic progenitor cells
Nat Commun. 11(1):5292. 2020.
Miyazaki M, Yada M, Tanaka K, Senjyu T, Goya T, Motomura K, Kohjima M, Kato M, Masumoto A, Kotoh K.
Efficacy of tolvaptan for the patients with advanced hepatocellular carcinoma
World J Gastroenterol. 23(29):5379-5385. 2017.