研究室紹介
Our Laboratories
研究室紹介
Our Laboratories
井本 効志 業績
原著論文
Imoto K, Tanaka M, Goya T, Azuma Y, Hioki T, Morita Y, Sakaguchi K, Fujita N, Kakino T, Ishikita A, Yamamura K, Sakamoto I, Ishigami K, Abe K, Ogawa Y.
Cisterna Chyli Dilation Is a Risk Factor for Liver Nodules and Hepatocellular Carcinoma in Fontan-Associated Liver Disease: Pathophysiological Role of Lymphatic Dysfunction
Hepatol Res. 2026 Sep 12. doi: 10.1111/hepr.70268. Online ahead of print.
Aoyagi T, Goya T, Imoto K, Azuma Y, Hioki T, Kohjima M, Tanaka M, Oda Y, Ogawa Y.
Two types of regenerative cell populations appear in acute liver injury.
Stem Cell Reports. 20(4):102503, 2025.
Imoto K, Goya T, Azuma Y, Hioki T, Aoyagi T, Nagata H, Nishizaki A, Kakino T, Ishikita A, Yamamura K, Sakamoto I, Tanaka M, Abe K, Ogawa Y.
Strain elastography for detecting advanced Fontan-associated liver disease: a retrospective study.
BMC Gastroenterol. 25:341, 2025.
Kido J, Häberle J, Sugawara K, Watanabe M, Imoto K, Yokota K, Kodaira M, Harai N, Sato K, Kakisaka K, Hattori Y, Nakamura K.
The current social status in adult patients with urea cycle disorders in Japan.
Molecular Genetics and Metabolism. 145(4):109185, 2025.
Hioki T, Imoto K, Goya T, Azuma Y, Horiuchi A, Aoyagi T, Takahashi M, Oda Y, Kato M, Kohjima M, Tanaka M, Ogawa Y.
Clinicopathological features of steroid-refractory immune-mediated hepatotoxicity induced by immune checkpoint inhibitors.
BMC Gastroenterol. 26(1):49, 2025.
Yoshimura R, Tanaka M, Kurokawa M, Nakamura N, Goya T, Imoto K, Kohjima M, Fujiu K, Iwami S, Ogawa Y.
Stratifying and predicting progression to acute liver failure during the early phase of acute liver injury.
PNAS Nexus. 4(2):pgaf004. 2025.
Kurokawa M, Goya T, Kohjima M, Tanaka M, Iwabuchi S, Shichino S, Ueha S, Hioki T, Aoyagi T, Takahashi M, Imoto K, Tashiro S, Suzuki H, Kato M, Hashimoto S, Matsuda H, Matsushima K, Ogawa Y.
Microcirculatory disturbance in acute liver injury is triggered by IFNγ-CD40 axis.
J Inflamm (Lond). 21(1):23, 2024.
Imoto K, Tanaka M, Goya T, Azuma Y, Hioki T, Aoyagi T, Takahashi M, Kurokawa M, Kato M, Kohjima M, Ogawa Y.
Acute kidney injury is an unfavorable prognostic factor in acute liver failure and is associated with tumor necrosis factor-alpha.
Medicine (Baltimore). 102(45):e35931. 2023.
Kuwano A, Okui T, Kohjima M, Kurokawa M, Goya T, Tanaka M, Aoyagi T, Takahashi M, Imoto K, Tashiro S, Suzuki H, Fujita N, Ushijima Y, Ishigami K, Tokunaga S, Kato M, Ogawa Y.Transcatheter arterial steroid injection therapy improves the prognosis of patients with acute liver failure.
Medicine (Baltimore). 102(10):e33090. 2023.
Imoto K, Tanaka M, Goya T, Aoyagi T, Takahashi M, Kurokawa M, Tashiro S, Kato M, Kohjima M, Ogawa Y.
Corticosteroid suppresses urea-cycle-related gene expressions in ornithine transcarbamylase deficiency.
BMC Gastroenterol. 22(1):144. 2022.
Tashiro S, Tanaka M, Goya T, Aoyagi T, Kurokawa M, Imoto K, Kuwano A, Takahashi M, Suzuki H, Kohjima M, Kato M, Ogawa Y.
Pirfenidone attenuates acetaminophen-induced liver injury via suppressing c-Jun N-terminal kinase phosphorylation
Toxicol Appl Pharmacol. 434:115817. 2022.
Suzuki H, Kohjima M, Tanaka M, Goya T, Itoh S, Yoshizumi T, Mori M, Tsuda M, Takahashi M, Kurokawa M, Imoto K, Tashiro S, Kuwano A, Kato M, Okada S, Nakamuta M, Ogawa Y.
Metabolic Alteration in Hepatocellular Carcinoma: Mechanism of Lipid Accumulation in Well-Differentiated Hepatocellular Carcinoma.
Can J Gastroenterol Hepatol. 8813410. 2021.
Kuwano A, Tanaka M, Suzuki H, Kurokawa M, Imoto K, Tashiro S, Goya T, Kohjima M, Kato M, Ogawa Y.
Upregulated expression of hypoxia reactive genes in peripheral blood mononuclear cells from chronic liver disease patients.
Biochem Biophys Rep. 27:101068. 2021.
Kuwano A, Kurokawa M, Kohjima M, Imoto K, Tashiro S, Suzuki H, Tanaka M, Okada S, Kato M, Ogawa Y.
Microcirculatory disturbance in acute liver injury
Exp Ther Med. 21(6):596. 2021.
Imoto K, Kohjima M, Hioki T, Kurashige T, Kurokawa M, Tashiro S, Suzuki H, Kuwano A, Tanaka M, Okada S, Kato M, Ogawa Y.
Clinical Features of Liver Injury Induced by Immune Checkpoint Inhibitors in Japanese Patients.
Can J Gastroenterol Hepatol. 6391712. 2019.
Kuwano A, Kohjima M, Suzuki H, Yamasaki A, Ohashi T, Imoto K, Kurokawa M, Morita Y, Kato M, Ogawa Y.
Recombinant human soluble thrombomodulin ameliorates acetaminophen-induced liver toxicity in mice.
Exp Ther Med. (2):1323-1330. 2019.
Cisterna Chyli Dilation Is a Risk Factor for Liver Nodules and Hepatocellular Carcinoma in Fontan-Associated Liver Disease: Pathophysiological Role of Lymphatic Dysfunction
Hepatol Res. 2026 Sep 12. doi: 10.1111/hepr.70268. Online ahead of print.
Aoyagi T, Goya T, Imoto K, Azuma Y, Hioki T, Kohjima M, Tanaka M, Oda Y, Ogawa Y.
Two types of regenerative cell populations appear in acute liver injury.
Stem Cell Reports. 20(4):102503, 2025.
Imoto K, Goya T, Azuma Y, Hioki T, Aoyagi T, Nagata H, Nishizaki A, Kakino T, Ishikita A, Yamamura K, Sakamoto I, Tanaka M, Abe K, Ogawa Y.
Strain elastography for detecting advanced Fontan-associated liver disease: a retrospective study.
BMC Gastroenterol. 25:341, 2025.
Kido J, Häberle J, Sugawara K, Watanabe M, Imoto K, Yokota K, Kodaira M, Harai N, Sato K, Kakisaka K, Hattori Y, Nakamura K.
The current social status in adult patients with urea cycle disorders in Japan.
Molecular Genetics and Metabolism. 145(4):109185, 2025.
Hioki T, Imoto K, Goya T, Azuma Y, Horiuchi A, Aoyagi T, Takahashi M, Oda Y, Kato M, Kohjima M, Tanaka M, Ogawa Y.
Clinicopathological features of steroid-refractory immune-mediated hepatotoxicity induced by immune checkpoint inhibitors.
BMC Gastroenterol. 26(1):49, 2025.
Yoshimura R, Tanaka M, Kurokawa M, Nakamura N, Goya T, Imoto K, Kohjima M, Fujiu K, Iwami S, Ogawa Y.
Stratifying and predicting progression to acute liver failure during the early phase of acute liver injury.
PNAS Nexus. 4(2):pgaf004. 2025.
Kurokawa M, Goya T, Kohjima M, Tanaka M, Iwabuchi S, Shichino S, Ueha S, Hioki T, Aoyagi T, Takahashi M, Imoto K, Tashiro S, Suzuki H, Kato M, Hashimoto S, Matsuda H, Matsushima K, Ogawa Y.
Microcirculatory disturbance in acute liver injury is triggered by IFNγ-CD40 axis.
J Inflamm (Lond). 21(1):23, 2024.
Imoto K, Tanaka M, Goya T, Azuma Y, Hioki T, Aoyagi T, Takahashi M, Kurokawa M, Kato M, Kohjima M, Ogawa Y.
Acute kidney injury is an unfavorable prognostic factor in acute liver failure and is associated with tumor necrosis factor-alpha.
Medicine (Baltimore). 102(45):e35931. 2023.
Kuwano A, Okui T, Kohjima M, Kurokawa M, Goya T, Tanaka M, Aoyagi T, Takahashi M, Imoto K, Tashiro S, Suzuki H, Fujita N, Ushijima Y, Ishigami K, Tokunaga S, Kato M, Ogawa Y.Transcatheter arterial steroid injection therapy improves the prognosis of patients with acute liver failure.
Medicine (Baltimore). 102(10):e33090. 2023.
Imoto K, Tanaka M, Goya T, Aoyagi T, Takahashi M, Kurokawa M, Tashiro S, Kato M, Kohjima M, Ogawa Y.
Corticosteroid suppresses urea-cycle-related gene expressions in ornithine transcarbamylase deficiency.
BMC Gastroenterol. 22(1):144. 2022.
Tashiro S, Tanaka M, Goya T, Aoyagi T, Kurokawa M, Imoto K, Kuwano A, Takahashi M, Suzuki H, Kohjima M, Kato M, Ogawa Y.
Pirfenidone attenuates acetaminophen-induced liver injury via suppressing c-Jun N-terminal kinase phosphorylation
Toxicol Appl Pharmacol. 434:115817. 2022.
Suzuki H, Kohjima M, Tanaka M, Goya T, Itoh S, Yoshizumi T, Mori M, Tsuda M, Takahashi M, Kurokawa M, Imoto K, Tashiro S, Kuwano A, Kato M, Okada S, Nakamuta M, Ogawa Y.
Metabolic Alteration in Hepatocellular Carcinoma: Mechanism of Lipid Accumulation in Well-Differentiated Hepatocellular Carcinoma.
Can J Gastroenterol Hepatol. 8813410. 2021.
Kuwano A, Tanaka M, Suzuki H, Kurokawa M, Imoto K, Tashiro S, Goya T, Kohjima M, Kato M, Ogawa Y.
Upregulated expression of hypoxia reactive genes in peripheral blood mononuclear cells from chronic liver disease patients.
Biochem Biophys Rep. 27:101068. 2021.
Kuwano A, Kurokawa M, Kohjima M, Imoto K, Tashiro S, Suzuki H, Tanaka M, Okada S, Kato M, Ogawa Y.
Microcirculatory disturbance in acute liver injury
Exp Ther Med. 21(6):596. 2021.
Imoto K, Kohjima M, Hioki T, Kurashige T, Kurokawa M, Tashiro S, Suzuki H, Kuwano A, Tanaka M, Okada S, Kato M, Ogawa Y.
Clinical Features of Liver Injury Induced by Immune Checkpoint Inhibitors in Japanese Patients.
Can J Gastroenterol Hepatol. 6391712. 2019.
Kuwano A, Kohjima M, Suzuki H, Yamasaki A, Ohashi T, Imoto K, Kurokawa M, Morita Y, Kato M, Ogawa Y.
Recombinant human soluble thrombomodulin ameliorates acetaminophen-induced liver toxicity in mice.
Exp Ther Med. (2):1323-1330. 2019.