研究室紹介
Our Laboratories
研究室紹介
Our Laboratories
田中 正剛 業績
原著論文
T. Hioki, K. Imoto, T. Goya, Y. Azuma, A. Horiuchi, T. Aoyagi, M. Takahashi, Y. Oda, M. Kato, M. Kohjima, M. Tanaka, Y. Ogawa. Clinicopathological features of steroid-refractory immune-mediated hepatotoxicity induced by immune checkpoint inhibitors. BMC Gastroenterol. 26(1):49, 2025.
Y. Morita, R. Sugimoto, M. Kurokawa, Y. Tanaka, T. Senju, T. Ichimaru, L. Lee, Y. Niina, T. Hisano, M. Furukawa, K. Sugimachi, M. Tanaka. Gemcitabine + Cisplatin + S-1 Treatment for Advanced Cholangiocarcinoma: Cost-Effective, with Better Progression-Free Survival Versus Standard Treatment with Gemcitabine + Cisplatin + Durvalumab. Cancers. 17(24):3971, 2025
K. Imoto, T. Goya, Y. Azuma, T. Hioki, T. Aoyagi, H. Nagata, A. Nishizaki, T. Kakino, A. Ishikita, K. Yamamura, I. Sakamoto, M. Tanaka, K. Abe, Y. Ogawa. Strain elastography for detecting advanced Fontan-associated liver disease: a retrospective study. BMC Gastroenterol. 25:341, 2025.
T. Aoyagi, T. Goya, K. Imoto, Y. Azuma, T. Hioki, M. Kohjima, M. Tanaka, Y. Oda, Y. Ogawa. Two types of regenerative cell populations appear in acute liver injury. Stem Cell Reports. 20(4):102503, 2025.
J. Kido, J. Häberle, K. Sugawara, M. Watanabe, K. Imoto, K. Yokota, M. Kodaira, N. Harai, K. Sato, K. Kakisaka, Y. Hattori, K. Nakamura. The current social status in adult patients with urea cycle disorders in Japan. Molecular Genetics and Metabolism. 145(4):109185, 2025.
E. Ogawa, M. Kohjima, T. Koyanagi, K. Dohmen, A. Ooho, A. Kawano, Furusyo N, Kajiwara E, Satoh T, Takahashi K, Azuma K, Sugimoto R, Ichiki Y, Senju T, Amagase H, Tanaka M, Nakamuta M, Nomura H, Hayashi J; Kyushu University Liver Disease Study (KULDS) Group. Five-Year Effectiveness and Renal Safety Following Switching to Tenofovir Alafenamide in Chronic Hepatitis B Patients with Renal Impairment. J Gastroenterol Hepatol. 40(10):2560-2567, 2025.
R. Yoshimura, M. Tanaka, M. Kurokawa, N. Nakamura, T. Goya, K. Imoto, M. Kohjima, et al. Stratifying and predicting progression to acute liver failure during the early phase of acute liver injury, PNAS Nexus. Vol. 4 Issue 2 Pages pgaf004, 2025.
E. Ogawa, A. Kawano, M. Kohjima, T. Koyanagi, K. Dohmen, A. Ooho, T. Satoh, et al. Long-Term Liver Morbidity and Mortality After Hepatitis C Virus Elimination by Direct-Acting Antivirals. J Gastroenterol Hepatol. 40(4):971-978, 2025.
M. Kurokawa, T. Goya, M. Kohjima, M. Tanaka, S. Iwabuchi, S. Shichino, S. Ueha, T. Hioki, T. Aoyagi, M. Takahashi, K. Imoto, S. Tashiro, H. Suzuki, M. Kato, S. Hashimoto, H. Matsuda, K. Matsushima, Y. Ogawa. Microcirculatory disturbance in acute liver injury is triggered by IFNγ-CD40 axis. J inflamm(Lond). 21(1):23, 2024.
M. Kurokawa, T. Hioki , T. Aoyagi, M. Takahashi, K. Imoto, T. Goya, M. Tanaka, M. Kohjima, Y. Ogawa. Clinicopathologic Features of Adult-onset Still's Disease Complicated by Severe Liver Injury. Intern med. 63(4):503-511, 2024.
J. Jeong, M. Tanaka, Y. Yang, N. Arefyev, J. DiRito, G. Tietjen, X. Zhang, M.J. McConnell, T. Utsumi, Y. Iwakiri. An optimized visualization and quantitative protocol for in-depth evaluation of lymphatic vessel architecture in the liver. Am J Physiol Gastrointest Liver Physiol 325:G379-g390, 2023.
K. Imoto, M. Tanaka, T. Goya, Y. Azuma, T. Hioki, T. Aoyagi, M. Takahashi, M. Kurokawa, M. Kato, M. Kohjima, Y. Ogawa. Acute kidney injury is an unfavorable prognostic factor in acute liver failure and is associated with tumor necrosis factor-alpha. Medicine (Baltimore) 102:e35931, 2023.
S. Fujinuma, H. Nakatsumi, H. Shimizu, S. Sugiyama, A. Harada, T. Goya, M. Tanaka, M. Kohjima, M. Takahashi, Y. Izumi, M. Yagi, D. Kang, M. Kaneko, M. Shigeta, T. Bamba, Y. Ohkawa, K. Nakayama. FOXK1 promotes nonalcoholic fatty liver disease by mediating mTORC1-dependent inhibition of hepatic fatty acid oxidation. Cell Rep 42:112530, 2023.
M. Tanaka, J. Jeong, C. Thomas, X. Zhang, P. Zhang, J. Saruwatari, R. Kondo, M. J. McConnell, T. Utsumi, Y. Iwakiri. The sympathetic nervous system promotes hepatic lymphangiogenesis, which is protective against liver fibrosis. Am J Pathol 193(12):2182-2202, 2023.
A. Kuwano, T. Okui, M. Kohjima, M. Kurokawa, T. Goya, M. Tanaka, T. Aoyagi, M. Takahashi, K. Imoto, S. Tashiro, H. Suzuki, N. Fujita, Y. Ushijima, K. Ishigami, S. Tokunaga, M. Kato, Y. Ogawa. Transcatheter arterial steroid injection therapy improves the prognosis of patients with acute liver failure. Medicine(Baltimore) 102(10):e33090, 2023.
R. Ohue-Kitano, H. Nonaka, A. Nishida, Y. Masujima, D. Takahashi, T. Ikeda, A. Uwamizu, M. Tanaka, M. Kohjima, M. Igarashi, H. Katoh, T. Tanaka, A. Inoue, T. Suganami, K. Hase, Y. Ogawa, J. Aoki, I. Kimura. Medium-chain fatty acids suppress lipotoxicity-induced hepatic fibrosis via the immunomodulating receptor GPR84. JCI Insight. 8(2): 165469,2023.
R. Sugimoto, K. Motomura, A. Ooho, Y. Aratake, A. Ueda, T. Senju, Y. Tanaka, M. Yada, K. Tanaka, A. Kuwano, Y. Morita, S. Nagasawa, M. Ooe, T. Mutsuki, T. Yoshimoto, N. Yamashita , M. Nakashima, T. Hioki, T. Koyanagi, N. Higuchi, T. Nakamura, S. Harada, M. Tanaka, S. Tada, T. Satoh, K. Uchimura, M. Kuniyoshi, M. Nakamuta, M. Kohjima; Liver Disease Investigators' Network of Kyushu University & Surrounding Hospitals (LINKS). Factors Contributing to the Prognosis after Second-line Therapy with Ramucirumab in Advanced Hepatocellular Carcinoma. Intern med 61(21):3157-3164, 2022.
T. Goya, M. Kurokawa, T. Hioki, T. Aoyagi, M. Takahashi, K. Imoto, S. Tashiro, H. Suzuki, M. Tanaka, M. Kato, M. Kohjima, Y. Ogawa. Elevated pancreatic enzymes associated with acute liver injury were mediated by tumor necrosis factor-alpha signaling. Hepat Mon 22(1):e128106, 2022.
T. Goya, K. Horisawa, M. Udono, Y. Ohkawa, Y. Ogawa, S. Sekiya, A. Suzuki. Direct conversion of human endothelial cells into liver cancer-forming cells using nonintegrateive episomal vectors. Hepatol Commun 6(7):1725-1740,2022.
K. Imoto, M. Tanaka, T. Goya, T. Aoyagi, M. Takahashi, M. Kurokawa, S. Tashiro, M. Kato, M. Kohjima, Y. Ogawa. Corticosteroid suppresses urea-cycle-related gene expressions in ornithine transcarbamylase deficiency. BMC Gastroenterol 22(1):144, 2022.
S. Tashiro, M. Tanaka, T. Goya, T. Aoyagi, M. Kurokawa, K. Imoto, A. Kuwano, M. Takahashi, H. Suzuki, M. Kohjima, M. Kato, Y. Ogawa. Pirfenidone attenuates acetaminophen-induced liver injury via suppressing c-Jun N-terminal kinase phosphorylation. Toxicol Appl Pharmacol 434:115817, 2022.
T. Goya, K. Imoto, S. Tashiro, T. Aoyagi, M. Takahashi, M. Kurokawa, H. Suzuki, M. Tanaka, M. Kato, M. Kohjima, Y. Ogawa. The Efficacy of Tofogliflozin on Metabolic Dysfunction-Associated Fatty Liver Disease. Gastroenterol Insights 13(1):20-26, 2022.
T. Goya, T. Kurashige, M. Kurokawa, M. Tanaka, T. Aoyagi, M. Takahashi, K. Imoto, S. Tashiro, H. Suzuki, M. Kato, M. Kohjima, Y. Ogawa. The Combination of Nucleotide Analog Therapy and Steroid Pulse Therapy for Acute HBV Infection Effectively Promotes HBV Clearance. Gastroenterol Insights 13(1):1-8, 2022.
A. Kuwano, M. Tanaka, H. Suzuki, M. Kurokawa, K. Imoto, S. Tashiro, T. Goya, M. Kohjima, M. Kato, Y. Ogawa. Upregulated expression of hypoxia reactive genes in peripheral blood mononuclear cells from chronic liver disease patients. Biochem Biophys Rep 27:101068, 2021.
A. Kuwano, M. Kurokawa, M. Kohjima, K. Imoto, S. Tashiro, H. Suzuki, M. Tanaka, S. Okada, M. Kato, Y. Ogawa. Microcirculatory disturbance in acute liver injury. Exp Ther Med 21(6):596-596, 2021.
M. Tanaka, T. Goya, H. Suzuki, M. Takahashi, K. Imoto, M. Kurokawa, S. Tashiro, A. Kuwano, S. Okada, M. Kato, M. Kohjima, K. Kotoh, Y. Ogawa. Hypoxic hepatitis with marked elevation of serum ferritin probably due to activation of intrahepatic macrophages: another form of hypoxic hepatitis hitherto not reported? Acta Gastro Enterologica Belgica 84(2):317-320, 2021.
H. Suzuki, M. Kohjima, M. Tanaka, T. Goya, S. Itoh, T. Yoshizumi, M. Mori, M. Tsuda, M. Takahashi, M. Kurokawa, K. Imoto, S. Tashiro, A. Kuwano, M. Kato, S. Okada, M. Nakamuta, Y. Ogawa. Metabolic Alteration in Hepatocellular Carcinoma: Mechanism of Lipid Accumulation in Well-Differentiated Hepatocellular Carcinoma. Can J Gastroenterol Hepatol 8813410, 2021.
S. Yoshizaki, K. Yokota, K. Kubota, T. Saito, M. Tanaka, D. J. Konno, T. Maeda, Y. Matsumoto, Y. Nakashima and S. Okada: The beneficial aspects of spasticity in relation to ambulatory ability in mice with spinal cord injury. Spinal Cord 58(5): 537-543, 2020.
Y. Okumura, K. Kohashi, Y. Tanaka, M. Kato, Y. Maehara, Y. Ogawa, Y. Oda. Activation of the Akt/mammalian target of rapamycin pathway in combined hepatocellular carcinoma and cholangiocarcinoma: significant correlation between p-4E-BP1 expression in cholangiocarcinoma component and prognosis. Virchows Arch. 476(6):881-890, 2020.
S. Yoshizaki, K. Kijima, M. Hara, T. Saito, T. Tamaru, M. Tanaka, D. J. Konno, Y. Nakashima and S. Okada: Tranexamic acid reduces heme cytotoxicity via the TLR4/TNF axis and ameliorates functional recovery after spinal cord injury. J Neuroinflammation 16(1): 160, 2019.
R. Takei, T. Inoue, N. Sonoda, M. Kohjima, M. Okamoto, R. Sakamoto, T. Inoguchi and Y. Ogawa: Bilirubin reduces visceral obesity and insulin resistance by suppression of inflammatory cytokines. PLoS One 14(10): e0223302, 2019.
A. Kuwano, M. Kohjima, H. Suzuki, A. Yamasaki, T. Ohashi, K. Imoto, M. Kurokawa, Y. Morita, M. Kato and Y. Ogawa: Recombinant human soluble thrombomodulin ameliorates acetaminophen-induced liver toxicity in mice. Exp Ther Med 18(2): 1323-1330, 2019.
M. Kido-Nakahara, T. Nakahara, N. Furusyo, S. Shimoda, K. Kotoh, M. Kato, J. Hayashi, T. Koyanagi and M. Furue: Pruritus in Chronic Liver Disease: A Questionnaire Survey on 216 Patients. Acta Derm Venereol 99(2):220-221, 2019.
K. Imoto, M. Kohjima, T. Hioki, T. Kurashige, M. Kurokawa, S. Tashiro, H. Suzuki, A. Kuwano, M. Tanaka, S. Okada, M. Kato and Y. Ogawa: Clinical Features of Liver Injury Induced by Immune Checkpoint Inhibitors in Japanese Patients. Can J Gastroenterol Hepatol 2019: 6391712, 2019.
M. Tanaka and Y. Iwakiri: Lymphatics in the liver. Curr Opin Immunol 53:137-142, 2018.
J. Saruwatari, C. Dong, T. Utsumi, M. Tanaka, M. McConnell and Y. Iwakiri: Integrated analysis of microRNA and mRNA expression profiles in splenomegaly induced by non-cirrhotic portal hypertension in rats. Sci Rep 8(1):17983, 2018.
M. Tanaka and Y. Iwakiri: The Hepatic Lymphatic Vascular System: Structure, Function, Markers, and Lymphangiogenesis. Cell Mol Gastroenterol Hepatol 2(6):733-749, 2016.
M. Tanaka, K. Tanaka, Y. Masaki, M. Miyazaki, M. Kato, K. Kotoh, M. Enjoji, M. Nakamuta and R. Takayanagi: Intrahepatic microcirculatory disorder, parenchymal hypoxia and NOX4 upregulation result in zonal differences in hepatocyte apoptosis following lipopolysaccharide- and D-galactosamine-induced acute liver failure in rats. Int J Mol Med 33(2):254-62, 2014.
K. Tanaka, Y. Masaki, M. Tanaka, M. Miyazaki, M. Enjoji, M. Nakamuta, M. Kato, M. Nomura, T. Inoguchi, K. Kotoh and R. Takayanagi: Exenatide improves hepatic steatosis by enhancing lipid use in adipose tissue in nondiabetic rats. World J Gastroenterol 20(10):2653-63, 2014.
M. Tanaka, Y. Masaki, K. Tanaka, M. Miyazaki, M. Kato, R. Sugimoto, K. Nakamura, S. Aishima, K. Shirabe, M. Nakamuta, M. Enjoji, K. Kotoh and R. Takayanagi: Reduction of fatty acid oxidation and responses to hypoxia correlate with the progression of de-differentiation in HCC. Mol Med Rep 7(2):365-70, 2013.
S. Takao, K. Tanaka, M. Miyazaki, M. Tanaka, T. Ohashi, M. Kato, K. Kotoh, S. Aishima and R. Takayanagi: A case of fatal intrahepatic cholestasis with primary AL amyloidosis: is early diagnosis possible? Clin J Gastroenterol 6(5):386-9, 2013.
M. Miyazaki, M. Kato, M. Tanaka, K. Tanaka, S. Takao, M. Kohjima, T. Ito, M. Enjoji, M. Nakamuta, K. Kotoh and R. Takayanagi: Antithrombin III injection via the portal vein suppresses liver damage. World J Gastroenterol 18(16):1884-91, 2012.
M. Miyazaki, M. Kato, K. Tanaka, M. Tanaka, M. Kohjima, K. Nakamura, M. Enjoji, M. Nakamuta, K. Kotoh and R. Takayanagi: Increased hepatic expression of dipeptidyl peptidase-4 in non-alcoholic fatty liver disease and its association with insulin resistance and glucose metabolism. Mol Med Rep 5(3):729-33, 2012.
M. Miyazaki, M. Tanaka, A. Ueda, T. Yoshimoto, M. Kato, M. Nakamuta, K. Kotoh and R. Takayanagi: Acute liver failure caused by drug-induced hypersensitivity syndrome associated with hyperferritinemia. World J Gastroenterol 17(44):4928-31, 2011.
M. Miyazaki, M. Kato, M. Tanaka, K. Tanaka, S. Takao, M. Kohjima, T. Ito, M. Enjoji, M. Nakamuta, K. Kotoh and R. Takayanagi: Contrast-enhanced ultrasonography using Sonazoid to evaluate changes in hepatic hemodynamics in acute liver injury. J Gastroenterol Hepatol 26(12):1749-56, 2011.
K. Kotoh, M. Kato, M. Kohjima, M. Tanaka, M. Miyazaki, K. Nakamura, M. Enjoji, M. Nakamuta and R. Takayanagi: Lactate dehydrogenase production in hepatocytes is increased at an early stage of acute liver failure. Exp Ther Med 2(2):195-199, 2011.
N. Higuchi, M. Kato, M. Tanaka, M. Miyazaki, S. Takao, M. Kohjima, K. Kotoh, M. Enjoji, M. Nakamuta and R. Takayanagi: Effects of insulin resistance and hepatic lipid accumulation on hepatic mRNA expression levels of apoB, MTP and L-FABP in non-alcoholic fatty liver disease. Exp Ther Med 2(6):1077-1081, 2011.
N. Higuchi, M. Kato, M. Miyazaki, M. Tanaka, M. Kohjima, T. Ito, M. Nakamuta, M. Enjoji, K. Kotoh and R. Takayanagi: Potential role of branched-chain amino acids in glucose metabolism through the accelerated induction of the glucose-sensing apparatus in the liver. J Cell Biochem 112(1):30-8, 2011.
M. Nakamuta, R. Yada, T. Fujino, M. Yada, N. Higuchi, M. Tanaka, M. Miyazaki, M. Kohjima, M. Kato, T. Yoshimoto, N. Harada, A. Taketomi, Y. Maehara, M. Koga, T. Nishinakagawa, M. Nakashima, K. Kotoh and M. Enjoji: Changes in the expression of cholesterol metabolism-associated genes in HCV-infected liver: a novel target for therapy? Int J Mol Med 24(6):825-8, 2009.
K. Kotoh, A. Ueda, M. Tanaka, M. Miyazaki, M. Kato, M. Kohjima, M. Enjoji, M. Nakamuta and R. Takayanagi: A high prevalence of extreme hyperferritinemia in acute hepatitis patients. Hepat Med 1:1-8, 2009.
N. Higuchi, M. Kato, Y. Shundo, H. Tajiri, M. Tanaka, N. Yamashita, M. Kohjima, K. Kotoh, M. Nakamuta, R. Takayanagi and M. Enjoji: Liver X receptor in cooperation with SREBP-1c is a major lipid synthesis regulator in nonalcoholic fatty liver disease. Hepatol Res 38(11):1122-9, 2008.
Y. Morita, R. Sugimoto, M. Kurokawa, Y. Tanaka, T. Senju, T. Ichimaru, L. Lee, Y. Niina, T. Hisano, M. Furukawa, K. Sugimachi, M. Tanaka. Gemcitabine + Cisplatin + S-1 Treatment for Advanced Cholangiocarcinoma: Cost-Effective, with Better Progression-Free Survival Versus Standard Treatment with Gemcitabine + Cisplatin + Durvalumab. Cancers. 17(24):3971, 2025
K. Imoto, T. Goya, Y. Azuma, T. Hioki, T. Aoyagi, H. Nagata, A. Nishizaki, T. Kakino, A. Ishikita, K. Yamamura, I. Sakamoto, M. Tanaka, K. Abe, Y. Ogawa. Strain elastography for detecting advanced Fontan-associated liver disease: a retrospective study. BMC Gastroenterol. 25:341, 2025.
T. Aoyagi, T. Goya, K. Imoto, Y. Azuma, T. Hioki, M. Kohjima, M. Tanaka, Y. Oda, Y. Ogawa. Two types of regenerative cell populations appear in acute liver injury. Stem Cell Reports. 20(4):102503, 2025.
J. Kido, J. Häberle, K. Sugawara, M. Watanabe, K. Imoto, K. Yokota, M. Kodaira, N. Harai, K. Sato, K. Kakisaka, Y. Hattori, K. Nakamura. The current social status in adult patients with urea cycle disorders in Japan. Molecular Genetics and Metabolism. 145(4):109185, 2025.
E. Ogawa, M. Kohjima, T. Koyanagi, K. Dohmen, A. Ooho, A. Kawano, Furusyo N, Kajiwara E, Satoh T, Takahashi K, Azuma K, Sugimoto R, Ichiki Y, Senju T, Amagase H, Tanaka M, Nakamuta M, Nomura H, Hayashi J; Kyushu University Liver Disease Study (KULDS) Group. Five-Year Effectiveness and Renal Safety Following Switching to Tenofovir Alafenamide in Chronic Hepatitis B Patients with Renal Impairment. J Gastroenterol Hepatol. 40(10):2560-2567, 2025.
R. Yoshimura, M. Tanaka, M. Kurokawa, N. Nakamura, T. Goya, K. Imoto, M. Kohjima, et al. Stratifying and predicting progression to acute liver failure during the early phase of acute liver injury, PNAS Nexus. Vol. 4 Issue 2 Pages pgaf004, 2025.
E. Ogawa, A. Kawano, M. Kohjima, T. Koyanagi, K. Dohmen, A. Ooho, T. Satoh, et al. Long-Term Liver Morbidity and Mortality After Hepatitis C Virus Elimination by Direct-Acting Antivirals. J Gastroenterol Hepatol. 40(4):971-978, 2025.
M. Kurokawa, T. Goya, M. Kohjima, M. Tanaka, S. Iwabuchi, S. Shichino, S. Ueha, T. Hioki, T. Aoyagi, M. Takahashi, K. Imoto, S. Tashiro, H. Suzuki, M. Kato, S. Hashimoto, H. Matsuda, K. Matsushima, Y. Ogawa. Microcirculatory disturbance in acute liver injury is triggered by IFNγ-CD40 axis. J inflamm(Lond). 21(1):23, 2024.
M. Kurokawa, T. Hioki , T. Aoyagi, M. Takahashi, K. Imoto, T. Goya, M. Tanaka, M. Kohjima, Y. Ogawa. Clinicopathologic Features of Adult-onset Still's Disease Complicated by Severe Liver Injury. Intern med. 63(4):503-511, 2024.
J. Jeong, M. Tanaka, Y. Yang, N. Arefyev, J. DiRito, G. Tietjen, X. Zhang, M.J. McConnell, T. Utsumi, Y. Iwakiri. An optimized visualization and quantitative protocol for in-depth evaluation of lymphatic vessel architecture in the liver. Am J Physiol Gastrointest Liver Physiol 325:G379-g390, 2023.
K. Imoto, M. Tanaka, T. Goya, Y. Azuma, T. Hioki, T. Aoyagi, M. Takahashi, M. Kurokawa, M. Kato, M. Kohjima, Y. Ogawa. Acute kidney injury is an unfavorable prognostic factor in acute liver failure and is associated with tumor necrosis factor-alpha. Medicine (Baltimore) 102:e35931, 2023.
S. Fujinuma, H. Nakatsumi, H. Shimizu, S. Sugiyama, A. Harada, T. Goya, M. Tanaka, M. Kohjima, M. Takahashi, Y. Izumi, M. Yagi, D. Kang, M. Kaneko, M. Shigeta, T. Bamba, Y. Ohkawa, K. Nakayama. FOXK1 promotes nonalcoholic fatty liver disease by mediating mTORC1-dependent inhibition of hepatic fatty acid oxidation. Cell Rep 42:112530, 2023.
M. Tanaka, J. Jeong, C. Thomas, X. Zhang, P. Zhang, J. Saruwatari, R. Kondo, M. J. McConnell, T. Utsumi, Y. Iwakiri. The sympathetic nervous system promotes hepatic lymphangiogenesis, which is protective against liver fibrosis. Am J Pathol 193(12):2182-2202, 2023.
A. Kuwano, T. Okui, M. Kohjima, M. Kurokawa, T. Goya, M. Tanaka, T. Aoyagi, M. Takahashi, K. Imoto, S. Tashiro, H. Suzuki, N. Fujita, Y. Ushijima, K. Ishigami, S. Tokunaga, M. Kato, Y. Ogawa. Transcatheter arterial steroid injection therapy improves the prognosis of patients with acute liver failure. Medicine(Baltimore) 102(10):e33090, 2023.
R. Ohue-Kitano, H. Nonaka, A. Nishida, Y. Masujima, D. Takahashi, T. Ikeda, A. Uwamizu, M. Tanaka, M. Kohjima, M. Igarashi, H. Katoh, T. Tanaka, A. Inoue, T. Suganami, K. Hase, Y. Ogawa, J. Aoki, I. Kimura. Medium-chain fatty acids suppress lipotoxicity-induced hepatic fibrosis via the immunomodulating receptor GPR84. JCI Insight. 8(2): 165469,2023.
R. Sugimoto, K. Motomura, A. Ooho, Y. Aratake, A. Ueda, T. Senju, Y. Tanaka, M. Yada, K. Tanaka, A. Kuwano, Y. Morita, S. Nagasawa, M. Ooe, T. Mutsuki, T. Yoshimoto, N. Yamashita , M. Nakashima, T. Hioki, T. Koyanagi, N. Higuchi, T. Nakamura, S. Harada, M. Tanaka, S. Tada, T. Satoh, K. Uchimura, M. Kuniyoshi, M. Nakamuta, M. Kohjima; Liver Disease Investigators' Network of Kyushu University & Surrounding Hospitals (LINKS). Factors Contributing to the Prognosis after Second-line Therapy with Ramucirumab in Advanced Hepatocellular Carcinoma. Intern med 61(21):3157-3164, 2022.
T. Goya, M. Kurokawa, T. Hioki, T. Aoyagi, M. Takahashi, K. Imoto, S. Tashiro, H. Suzuki, M. Tanaka, M. Kato, M. Kohjima, Y. Ogawa. Elevated pancreatic enzymes associated with acute liver injury were mediated by tumor necrosis factor-alpha signaling. Hepat Mon 22(1):e128106, 2022.
T. Goya, K. Horisawa, M. Udono, Y. Ohkawa, Y. Ogawa, S. Sekiya, A. Suzuki. Direct conversion of human endothelial cells into liver cancer-forming cells using nonintegrateive episomal vectors. Hepatol Commun 6(7):1725-1740,2022.
K. Imoto, M. Tanaka, T. Goya, T. Aoyagi, M. Takahashi, M. Kurokawa, S. Tashiro, M. Kato, M. Kohjima, Y. Ogawa. Corticosteroid suppresses urea-cycle-related gene expressions in ornithine transcarbamylase deficiency. BMC Gastroenterol 22(1):144, 2022.
S. Tashiro, M. Tanaka, T. Goya, T. Aoyagi, M. Kurokawa, K. Imoto, A. Kuwano, M. Takahashi, H. Suzuki, M. Kohjima, M. Kato, Y. Ogawa. Pirfenidone attenuates acetaminophen-induced liver injury via suppressing c-Jun N-terminal kinase phosphorylation. Toxicol Appl Pharmacol 434:115817, 2022.
T. Goya, K. Imoto, S. Tashiro, T. Aoyagi, M. Takahashi, M. Kurokawa, H. Suzuki, M. Tanaka, M. Kato, M. Kohjima, Y. Ogawa. The Efficacy of Tofogliflozin on Metabolic Dysfunction-Associated Fatty Liver Disease. Gastroenterol Insights 13(1):20-26, 2022.
T. Goya, T. Kurashige, M. Kurokawa, M. Tanaka, T. Aoyagi, M. Takahashi, K. Imoto, S. Tashiro, H. Suzuki, M. Kato, M. Kohjima, Y. Ogawa. The Combination of Nucleotide Analog Therapy and Steroid Pulse Therapy for Acute HBV Infection Effectively Promotes HBV Clearance. Gastroenterol Insights 13(1):1-8, 2022.
A. Kuwano, M. Tanaka, H. Suzuki, M. Kurokawa, K. Imoto, S. Tashiro, T. Goya, M. Kohjima, M. Kato, Y. Ogawa. Upregulated expression of hypoxia reactive genes in peripheral blood mononuclear cells from chronic liver disease patients. Biochem Biophys Rep 27:101068, 2021.
A. Kuwano, M. Kurokawa, M. Kohjima, K. Imoto, S. Tashiro, H. Suzuki, M. Tanaka, S. Okada, M. Kato, Y. Ogawa. Microcirculatory disturbance in acute liver injury. Exp Ther Med 21(6):596-596, 2021.
M. Tanaka, T. Goya, H. Suzuki, M. Takahashi, K. Imoto, M. Kurokawa, S. Tashiro, A. Kuwano, S. Okada, M. Kato, M. Kohjima, K. Kotoh, Y. Ogawa. Hypoxic hepatitis with marked elevation of serum ferritin probably due to activation of intrahepatic macrophages: another form of hypoxic hepatitis hitherto not reported? Acta Gastro Enterologica Belgica 84(2):317-320, 2021.
H. Suzuki, M. Kohjima, M. Tanaka, T. Goya, S. Itoh, T. Yoshizumi, M. Mori, M. Tsuda, M. Takahashi, M. Kurokawa, K. Imoto, S. Tashiro, A. Kuwano, M. Kato, S. Okada, M. Nakamuta, Y. Ogawa. Metabolic Alteration in Hepatocellular Carcinoma: Mechanism of Lipid Accumulation in Well-Differentiated Hepatocellular Carcinoma. Can J Gastroenterol Hepatol 8813410, 2021.
S. Yoshizaki, K. Yokota, K. Kubota, T. Saito, M. Tanaka, D. J. Konno, T. Maeda, Y. Matsumoto, Y. Nakashima and S. Okada: The beneficial aspects of spasticity in relation to ambulatory ability in mice with spinal cord injury. Spinal Cord 58(5): 537-543, 2020.
Y. Okumura, K. Kohashi, Y. Tanaka, M. Kato, Y. Maehara, Y. Ogawa, Y. Oda. Activation of the Akt/mammalian target of rapamycin pathway in combined hepatocellular carcinoma and cholangiocarcinoma: significant correlation between p-4E-BP1 expression in cholangiocarcinoma component and prognosis. Virchows Arch. 476(6):881-890, 2020.
S. Yoshizaki, K. Kijima, M. Hara, T. Saito, T. Tamaru, M. Tanaka, D. J. Konno, Y. Nakashima and S. Okada: Tranexamic acid reduces heme cytotoxicity via the TLR4/TNF axis and ameliorates functional recovery after spinal cord injury. J Neuroinflammation 16(1): 160, 2019.
R. Takei, T. Inoue, N. Sonoda, M. Kohjima, M. Okamoto, R. Sakamoto, T. Inoguchi and Y. Ogawa: Bilirubin reduces visceral obesity and insulin resistance by suppression of inflammatory cytokines. PLoS One 14(10): e0223302, 2019.
A. Kuwano, M. Kohjima, H. Suzuki, A. Yamasaki, T. Ohashi, K. Imoto, M. Kurokawa, Y. Morita, M. Kato and Y. Ogawa: Recombinant human soluble thrombomodulin ameliorates acetaminophen-induced liver toxicity in mice. Exp Ther Med 18(2): 1323-1330, 2019.
M. Kido-Nakahara, T. Nakahara, N. Furusyo, S. Shimoda, K. Kotoh, M. Kato, J. Hayashi, T. Koyanagi and M. Furue: Pruritus in Chronic Liver Disease: A Questionnaire Survey on 216 Patients. Acta Derm Venereol 99(2):220-221, 2019.
K. Imoto, M. Kohjima, T. Hioki, T. Kurashige, M. Kurokawa, S. Tashiro, H. Suzuki, A. Kuwano, M. Tanaka, S. Okada, M. Kato and Y. Ogawa: Clinical Features of Liver Injury Induced by Immune Checkpoint Inhibitors in Japanese Patients. Can J Gastroenterol Hepatol 2019: 6391712, 2019.
M. Tanaka and Y. Iwakiri: Lymphatics in the liver. Curr Opin Immunol 53:137-142, 2018.
J. Saruwatari, C. Dong, T. Utsumi, M. Tanaka, M. McConnell and Y. Iwakiri: Integrated analysis of microRNA and mRNA expression profiles in splenomegaly induced by non-cirrhotic portal hypertension in rats. Sci Rep 8(1):17983, 2018.
M. Tanaka and Y. Iwakiri: The Hepatic Lymphatic Vascular System: Structure, Function, Markers, and Lymphangiogenesis. Cell Mol Gastroenterol Hepatol 2(6):733-749, 2016.
M. Tanaka, K. Tanaka, Y. Masaki, M. Miyazaki, M. Kato, K. Kotoh, M. Enjoji, M. Nakamuta and R. Takayanagi: Intrahepatic microcirculatory disorder, parenchymal hypoxia and NOX4 upregulation result in zonal differences in hepatocyte apoptosis following lipopolysaccharide- and D-galactosamine-induced acute liver failure in rats. Int J Mol Med 33(2):254-62, 2014.
K. Tanaka, Y. Masaki, M. Tanaka, M. Miyazaki, M. Enjoji, M. Nakamuta, M. Kato, M. Nomura, T. Inoguchi, K. Kotoh and R. Takayanagi: Exenatide improves hepatic steatosis by enhancing lipid use in adipose tissue in nondiabetic rats. World J Gastroenterol 20(10):2653-63, 2014.
M. Tanaka, Y. Masaki, K. Tanaka, M. Miyazaki, M. Kato, R. Sugimoto, K. Nakamura, S. Aishima, K. Shirabe, M. Nakamuta, M. Enjoji, K. Kotoh and R. Takayanagi: Reduction of fatty acid oxidation and responses to hypoxia correlate with the progression of de-differentiation in HCC. Mol Med Rep 7(2):365-70, 2013.
S. Takao, K. Tanaka, M. Miyazaki, M. Tanaka, T. Ohashi, M. Kato, K. Kotoh, S. Aishima and R. Takayanagi: A case of fatal intrahepatic cholestasis with primary AL amyloidosis: is early diagnosis possible? Clin J Gastroenterol 6(5):386-9, 2013.
M. Miyazaki, M. Kato, M. Tanaka, K. Tanaka, S. Takao, M. Kohjima, T. Ito, M. Enjoji, M. Nakamuta, K. Kotoh and R. Takayanagi: Antithrombin III injection via the portal vein suppresses liver damage. World J Gastroenterol 18(16):1884-91, 2012.
M. Miyazaki, M. Kato, K. Tanaka, M. Tanaka, M. Kohjima, K. Nakamura, M. Enjoji, M. Nakamuta, K. Kotoh and R. Takayanagi: Increased hepatic expression of dipeptidyl peptidase-4 in non-alcoholic fatty liver disease and its association with insulin resistance and glucose metabolism. Mol Med Rep 5(3):729-33, 2012.
M. Miyazaki, M. Tanaka, A. Ueda, T. Yoshimoto, M. Kato, M. Nakamuta, K. Kotoh and R. Takayanagi: Acute liver failure caused by drug-induced hypersensitivity syndrome associated with hyperferritinemia. World J Gastroenterol 17(44):4928-31, 2011.
M. Miyazaki, M. Kato, M. Tanaka, K. Tanaka, S. Takao, M. Kohjima, T. Ito, M. Enjoji, M. Nakamuta, K. Kotoh and R. Takayanagi: Contrast-enhanced ultrasonography using Sonazoid to evaluate changes in hepatic hemodynamics in acute liver injury. J Gastroenterol Hepatol 26(12):1749-56, 2011.
K. Kotoh, M. Kato, M. Kohjima, M. Tanaka, M. Miyazaki, K. Nakamura, M. Enjoji, M. Nakamuta and R. Takayanagi: Lactate dehydrogenase production in hepatocytes is increased at an early stage of acute liver failure. Exp Ther Med 2(2):195-199, 2011.
N. Higuchi, M. Kato, M. Tanaka, M. Miyazaki, S. Takao, M. Kohjima, K. Kotoh, M. Enjoji, M. Nakamuta and R. Takayanagi: Effects of insulin resistance and hepatic lipid accumulation on hepatic mRNA expression levels of apoB, MTP and L-FABP in non-alcoholic fatty liver disease. Exp Ther Med 2(6):1077-1081, 2011.
N. Higuchi, M. Kato, M. Miyazaki, M. Tanaka, M. Kohjima, T. Ito, M. Nakamuta, M. Enjoji, K. Kotoh and R. Takayanagi: Potential role of branched-chain amino acids in glucose metabolism through the accelerated induction of the glucose-sensing apparatus in the liver. J Cell Biochem 112(1):30-8, 2011.
M. Nakamuta, R. Yada, T. Fujino, M. Yada, N. Higuchi, M. Tanaka, M. Miyazaki, M. Kohjima, M. Kato, T. Yoshimoto, N. Harada, A. Taketomi, Y. Maehara, M. Koga, T. Nishinakagawa, M. Nakashima, K. Kotoh and M. Enjoji: Changes in the expression of cholesterol metabolism-associated genes in HCV-infected liver: a novel target for therapy? Int J Mol Med 24(6):825-8, 2009.
K. Kotoh, A. Ueda, M. Tanaka, M. Miyazaki, M. Kato, M. Kohjima, M. Enjoji, M. Nakamuta and R. Takayanagi: A high prevalence of extreme hyperferritinemia in acute hepatitis patients. Hepat Med 1:1-8, 2009.
N. Higuchi, M. Kato, Y. Shundo, H. Tajiri, M. Tanaka, N. Yamashita, M. Kohjima, K. Kotoh, M. Nakamuta, R. Takayanagi and M. Enjoji: Liver X receptor in cooperation with SREBP-1c is a major lipid synthesis regulator in nonalcoholic fatty liver disease. Hepatol Res 38(11):1122-9, 2008.