九州大学大学院医学研究院 病態制御内学科(第三内科) 九州大学大学院医学研究院 病態制御内学科(第三内科)

Our Laboratories

土師 正二郎 業績

原著論文

Akihisa Ohno, Nao Fujimori, Kazuhide Matsumoto, Shojiro Haji, Osamu Sugahara, Ayumu Takeno, Takeo Yamamoto, Akihiko Suenaga, Shotaro Kakehashi, Takahiro Ueda, Masatoshi Murakami, Katsuhito Teramatsu, Keijiro Ueda, Takamasa Oono, Yoshinao Oda, Keiichi I Nakayama, Yoshihiro Ogawa.
Role of the transmembrane protein, epithelial membrane protein 1, in the pathogenesis of pancreatic ductal adenocarcinoma
Oncogene. 2025 Dec 10. doi: 10.1038/s41388-025-03633-4. Online ahead of print.

Shojiro Haji, Yoshihiro Ogawa.
TET3-overexpressing macrophages are a unifying pathogenic feature with therapeutic potential in chronic inflammatory diseases.

The Journal of clinical investigation. 2025;135(21):e198802. https://doi.org/10.1172/JCI198802.

Yasuhiro Tsukamoto, Atsuki Kawamura, Ayhan Yurtsever, Hidefumi Suzuki, Nichole Marcela Rojas-Chaverra, Hiroki Sato, Daisuke Ino, Takehiko Ichikawa, Weilin Wei, Shojiro Haji, Dominic Chih-Cheng Voon, Akinobu Matsumoto, Kunio Matsumoto, Hidehisa Takahashi, Noriyuki Kodera, Takeshi Fukuma, Yoshihiro Ogawa, Masaaki Nishiyama, Katsuya Sakai.
Condensation-dependent interactome of a chromatin remodeler underlies tumor suppressor activities.
Nat Communications 16, 9599 (2025). https://doi.org/10.1038/s41467-025-64655-w


Fujioka E, Kiyasu J, Choi I, Yagi Y, Sawabe T, Oyama M, Hoashi K, Tsuda M, Takamatsu A, Haji S, Yufu Y, Suehiro Y, Shiratsuchi M.
Efficacy and Safety of Rituximab plus Modified EPOCH (Etoposide, Vincristine, Doxorubicin, Carboplatin, and Prednisolone) for Transplant-ineligible Relapsed/Refractory Diffuse Large B-cell Lymphoma.
Intern Med. 2025 Apr 12.  Online ahead of print.

Haji S, Ito T, Guenther G, Nakano M, Shimizu T, Mori D, Chiba Y, Tanaka M, Mishra SK, Willment JA, Brown GD, Nagae M, Yamasaki S.
Human Dectin-1 is O-glycosylated and serves as a ligand for C-type lectin receptor CLEC-2.
Elife. 2022 Dec 8;11:e83037. 

Haji S, Shiratsuchi M, Takamatsu A, Tsuda M, Muta H, Masuda T, Nakashima Y, Ogawa Y.
Endothelial function testing before conditioning therapy is useful for predicting transplant-related complications after allogeneic hematopoietic cell transplantation
Int J Hematol. 2023 Mar;117(3):438-445.  

Masuda T, Haji S, Nakashima Y, Tsuda M, Kimura D, Takamatsu A, Iwahashi N, Umakoshi H,  Shiratsuchi M, Kikutake C, Suyama M, Ohkawa Y, Ogawa Y.
Identification of a drug-response gene in multiple myeloma through longitudinal single-cell transcriptome sequencing
iScience. 2022 Jul 19; 25(8):104781.

Tsuda M, Hirata A, Tokunaga S, Masuda T, Haji S, Kimura D, Nojiri C, Nakashima Y, Shitatsuchi M, Kato K, Miyamoto T, Akashi K, Nakashima N, Ogawa Y.
Rapid decrease in eGFR with concomitant use of tyrosine kinase inhibitors and renin-aldosterone-angiotensin system inhibitors in patients with chronic myelogeous leukemia.
Int J Hematol. 2022 Aug 6. 

Takamatsu A, Nakashima Y, Haji S, Tsuda M, Masuda T, Kimura D, Shitatsuchi M, Ogawa Y.
Circulating endothelial cells and endothelial progenitor cells as potential predictors of acute GVHD after allogeneic hematopoietic stem cell transplantation.
Eur J Haematol. 2022 Apr 23.  

Nagata M, Toyonaga K, Ishikawa E, Haji S, Okahashi N, Takahashi M, Izumi Y, Imamura A, Takato K, Ishida H, Nagai S, Illarionov P, Stocker B, Timmer MS, Smith DGM, Williams SJ, Bamba T, Miyamoto T, Arita M, Appelmelk BJ, Yamasaki S.
Helicobactermetabolites exacerbate gastritis through C-type lectin receptors. 
Journal of Experimental Medicine, 2021 Jan 4;218(1):e20200815. 

Tsukamoto Y, Kiyasu J, Choi I, Kozuru M, Uike N, Utsunomiya H, Hirata A, Fujioka E, Ohno H, Nakashima E, Nakashima Y, Miyashita K, Tachikawa Y, Narazaki T, Tsuda M, Haji S, Takamatsu A, Tanaka E, Goto T, Takatsuki H, Oyama M, Muta H, Yagi Y, Ikeda M, Matsushima T, Yufu Y, Suehiro Y: Efficacy and Safety of the Modified EPOCH Regimen (Etoposide, Vincristine, Doxorubicin, Carboplatin, and Prednisolone) for Adult T-cell Leukemia/Lymphoma: A Multicenter Retrospective Study.
Clinical Lymphoma, Myeloma and Leukemia. 20(7):e445-e453, 2020

Kiyasu J, Arakawa F, , Tachikawa Y, Tsuda M, Tsukamoto Y, Ikeda M, Muta H, Haji S, Matsushima T, Miyoshi H, Shiratsuchi M, Ogawa Y, Oshima K, Yufu Y: Methotrexate‐associated lymphoproliferative disorders with angioimmunoblastic T‐cell lymphoma‐like features accompanied by gamma‐heavy chain disease in a patient with rheumatoid arthritis. 
Pathology international 68(8): 485-490, 2018

Haji S, Kiyasu J, Choi I, Suehiro Y, Toyoda K, Tsuda M, Takamatsu A, Nakashima Y, Miyoshi, H, Shiratsuchi M, Yamasaki S, Uike N, Abe Y: Administration of an anti-CC chemokine receptor 4 monoclonal antibody, mogamulizumab, before allogeneic bone marrow transplantation for adult T-cell leukemia/lymphoma. 
Bone marrow transplantation. 51(3): 432-434, 2017

Haji S, Shiratsuchi M, Matsushima T, Takamatsu A, Tsuda M, Tsukamoto Y, Tanaka E, Ohno H, Fujioka E, Ishikawa Y, Imadome K, Ogawa Y: Achievement of disease control with donor-derived B virus-specific cytotoxic T cells after allogeneic peripheral blood stem cell transplantation for aggressive NK-cell leukemia. 
International journal of hematology105(4): 540-544, 2017

Narazaki T, Haji S, Nakashima Y, Tsukamoto Y, Tsuda M, Takamatsu A, Ohno H, Matsushima T, Matsumoto T, Nogami K, Shima M, Shiratsuchi M, Ogawa Y: Acquired hemophilia A associated with autoimmune pancreatitis with serum IgG4 elevation. 
International journal of hematology, 108(3): 335-338, 2017

土師 正二郎, 喜安 純一, 立川 義倫, 豊永 次郎, 池田 元彦, 津田 麻理子, 塚本 康寛, 小鶴 三男, 油布 祐二: 自家末梢血幹細胞移植後に自然脾破裂を合併した軽鎖沈着症.
臨床血液, 57(6): 754-759, 2016. 

土師 正二郎, 安部 康信, 津田 麻理子, 豊田 康祐, 崔 日承, 末廣 陽子, 白土 基明, 喜安 純一, 鵜池 直邦: リンパ形質細胞様形態を呈し低悪性度B細胞リンパ腫との鑑別を要したCD20陽性骨髄腫.
臨床血液, 56(3): 335-338, 2015.

著書・総説

西村 直矢, 土師 正二郎, 本園 千尋. 結核菌を認識するあらたなC型レクチン受容体. 
医学のあゆみ 261(13):1243-1244, 2017.