研究室紹介
Our Laboratories
研究室紹介
Our Laboratories
知念 孝敏 業績
原著論文
Igarashi-Hisayoshi Y, Ihara E, Bai X, Tanaka Y, Ogino H, Chinen T, et al. Protective role of M(3) muscarinic acetylcholine receptor in indomethacin-induced small intestinal injury. J Mol Med (Berl). 2024;102(9):1175-86. Epub 20240822.
Nishioka K, Ogino H, Ihara E, Chinen T, Kimura Y, Esaki M, et al. Importance of rectal over colon status in ulcerative colitis remission: the role of microinflammation and mucosal barrier dysfunction in relapse. J Gastroenterol. 2024. Epub 20241213.
Igarashi HY, Ihara E, Bai X, Higashi C, Ikeda H, Tanaka Y, Hirano M, Ogino H, Chinen T, Taguchi Y, Ogawa Y:
Determination of region-specific roles of the M3 muscarinic acetylcholine receptor in gastrointestinal motility.
Dig Dis Sci 68(2): 439-450,2023
Minoda Y, Esaki M, Ihara E, Nagatomo S, Nishioka K, Fujimori N, Ogino H, Bai X,Tanaka Y,i Chnen T, Hu Q, Ota M, Umekita S, Yamamoto H, Ogawa Y:Auxilliary diagnosis of subepithelial lesions by impedance measurement during endoscopic ultrasound fine-needle aspiration biopsy. gastrointest Endosc 97(5): 977-984, 2023
Ihara E, Ogino H, Muta K, Hamada S, Wada M, Hata Y, Ikeda H, Bai X, Minoda Y, Esaki M, Tanaka Y, Chinen T, Ogawa Y: The treatment effects of acotiamide in esophagogastric outflow obstruction: A prospective longitudinal observational study. Esophagus 19(2): 332-342, 2022
Igarashi-Hisayoshi Y, Ihara E, Bai X, Higashi C, Ikeda H, Tanaka Y, Hirano M, Ogino H, Chinen T, Taguchi Y, Ogawa Y: Determination of region-specific roles of the m3 muscarinic acetylcholine receptor in gastrointestinal motility. Dig Dis Sci 2022
Hata Y, Ihara E, Wada M, Tsuru H, Muta K, Minoda Y, Bai X, Esaki M, Tanaka Y, Chinen T, Ogino H, Sakamoto R, Ogawa Y: Improved esophagography screening for esophageal motility disorders using wave appearance and supra-junctional ballooning. J Gastroenterol 57(11): 838-847, 2022
Hamada S, Ihara E, Muta K, Wada M, Hata Y, Ikeda H, Tanaka Y, Ogino H, Chinen T, Ogawa Y: Onigiri esophagography as a screening test for esophageal motility disorders. J Neurogastroenterol Motil 28(1): 43-52, 2022
Campbell C, Dikiy S, Bhattarai SK, Chinen T, Matheis F, Calafiore M, Hoyos B, Hanash A, Mucida D, Bucci V, Rudensky AY. Extrathymically Generated Regulatory T Cells Establish a Niche for Intestinal Border-Dwelling Bacteria and Affect Physiologic Metabolite Balance. Immunity. 48:1245-1257,2018
Chinen T, Kannan AK, Levine AG, Fan X, Klein U, Gasteiger G, Feng Y, Fontenot JD, Rudensky AY.An essential role for the IL-2 receptor in Treg cell function.Nat Immunol. 17:1322-1333, 2016
Feng Y, Arvey A, Chinen T, van der Veeken J, Gasteiger G, Rudensky AY.Control of the inheritance of regulatory T cell identity by a cis element in the Foxp3 locus.Cell. 158:749-63, 2014
Josefowicz S, Niec R, Kim HY, Treuting P, Chinen T, Umetsu DT, Rudensky AY. Extrathymically generated regulatory T cells control mucosal Th2 inflammation. Nature. 482:395-9, 2012
Chinen T, Komai K, Muto G, Morita R, Inoue N, Yoshida H, Sekiya T, Nakamura K, Yoshimura A. Prostaglandin E2 and SOCS1 have a role in intestinal immune tolerance. Nat Commun. 2:190, 2011
Takahashi R, Nishimoto S, Muto G, Sekiya T, Tamiya T, Kimura A, Morita R, Chinen T, Yoshimura A. SOCS1 is essential for Treg cell functions by preventing loss of Foxp3 expression as well as IFN-g and IL-17A production. J Exp Med. 208:2055-67, 2011
Chinen T, Volchkov PY, Chervonsky AV, Rudensky AY. A critical role for regulatory T cell-mediated control of inflammation in the absence of commensal microbiota. J Exp Med. 207:2323-30, 2010
Ichiyama K, Yoshida H, Wakabayashi Y, Chinen T, Saeki K, Takaesu G, Hori S, Yoshimura A, Kobayashi T. Foxp3 inhibits RORgt-mediated IL-17A mRNA transcription through direct interaction with RORgt. J Biol Chem. 283:17003-8, 2008
Ogata H, Kobayashi T, Chinen T, Takaki H, Sanada T, Minoda Y, Koga K, Takaesu G, Yoshimura A. Deletion of the SOCS3 gene in liver parenchymal cells promotes hepatitis-induced hepatocarcinogenesis. Gastroenterology. 131:179-93, 2006
Chinen T, Kobayashi T, Ogata H, Takaesu G, Takaki H, Yagita H, Nawata H, Yoshimura A. SOCS1 regulates inflammatory bowel disease in which both IFNg and IL-4 are involved. Gastroenterology. 130:373-88, 2006
Hanada T, Kobayashi T, Chinen T, Saeki K, Takaki H, Koga K, Minoda Y, Sanada T, Yoshimura A. IFNg-dependent, spontaneous development of colorectal carcinomas in SOCS1-deficient mice. J Exp Med. 203:1391-7, 2006
Ogata H, Chinen T, Yoshida T, Kinjyo I, Takaesu G, Shiraishi H, Iida M, Kobayashi T, Yoshimura A. Loss of SOCS3 in the liver promotes fibrosis by enhancing STAT3-mediated TGF-b1 production. Oncogene. 25:2520-30, 2006
Chinen T, Misawa T, Yao T, Nasu T, Yoshida K, Kubo S, Toyoshima S, Sakaguchi T, Harada N. Pedunculated cap polyps preceding the development of cap polyposis: case report. Gastrointest Endosc. 61:338-40, 2005
Chinen T, Misawa T, Yoshida K, Nasu T, Kubo S, Toyoshima S, Yao T, Harada N. Esophageal submucosal gland duct adenoma. Gastrointest Endos. 60:798-9, 2004
Inagaki-Ohara K, Chinen T, Matsuzaki G, Sasaki A, Sakamoto Y, Hiromatsu K, Nawa Y, Yoshimura A. Mucosal T cells bearing TCRgd play a protective role in intestinal inflammation. J Immunol. 173:1390-8, 2004
Yasukawa H, Ohishi M, Mori H, Murakami M, Chinen T, Takeda K, Akira S, Hoshijima M, Hirano T, Yoshimura A. IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages. Nat Immunol. 4:551-6, 2003
Nishioka K, Ogino H, Ihara E, Chinen T, Kimura Y, Esaki M, et al. Importance of rectal over colon status in ulcerative colitis remission: the role of microinflammation and mucosal barrier dysfunction in relapse. J Gastroenterol. 2024. Epub 20241213.
Igarashi HY, Ihara E, Bai X, Higashi C, Ikeda H, Tanaka Y, Hirano M, Ogino H, Chinen T, Taguchi Y, Ogawa Y:
Determination of region-specific roles of the M3 muscarinic acetylcholine receptor in gastrointestinal motility.
Dig Dis Sci 68(2): 439-450,2023
Minoda Y, Esaki M, Ihara E, Nagatomo S, Nishioka K, Fujimori N, Ogino H, Bai X,Tanaka Y,i Chnen T, Hu Q, Ota M, Umekita S, Yamamoto H, Ogawa Y:Auxilliary diagnosis of subepithelial lesions by impedance measurement during endoscopic ultrasound fine-needle aspiration biopsy. gastrointest Endosc 97(5): 977-984, 2023
Ihara E, Ogino H, Muta K, Hamada S, Wada M, Hata Y, Ikeda H, Bai X, Minoda Y, Esaki M, Tanaka Y, Chinen T, Ogawa Y: The treatment effects of acotiamide in esophagogastric outflow obstruction: A prospective longitudinal observational study. Esophagus 19(2): 332-342, 2022
Igarashi-Hisayoshi Y, Ihara E, Bai X, Higashi C, Ikeda H, Tanaka Y, Hirano M, Ogino H, Chinen T, Taguchi Y, Ogawa Y: Determination of region-specific roles of the m3 muscarinic acetylcholine receptor in gastrointestinal motility. Dig Dis Sci 2022
Hata Y, Ihara E, Wada M, Tsuru H, Muta K, Minoda Y, Bai X, Esaki M, Tanaka Y, Chinen T, Ogino H, Sakamoto R, Ogawa Y: Improved esophagography screening for esophageal motility disorders using wave appearance and supra-junctional ballooning. J Gastroenterol 57(11): 838-847, 2022
Hamada S, Ihara E, Muta K, Wada M, Hata Y, Ikeda H, Tanaka Y, Ogino H, Chinen T, Ogawa Y: Onigiri esophagography as a screening test for esophageal motility disorders. J Neurogastroenterol Motil 28(1): 43-52, 2022
Campbell C, Dikiy S, Bhattarai SK, Chinen T, Matheis F, Calafiore M, Hoyos B, Hanash A, Mucida D, Bucci V, Rudensky AY. Extrathymically Generated Regulatory T Cells Establish a Niche for Intestinal Border-Dwelling Bacteria and Affect Physiologic Metabolite Balance. Immunity. 48:1245-1257,2018
Chinen T, Kannan AK, Levine AG, Fan X, Klein U, Gasteiger G, Feng Y, Fontenot JD, Rudensky AY.An essential role for the IL-2 receptor in Treg cell function.Nat Immunol. 17:1322-1333, 2016
Feng Y, Arvey A, Chinen T, van der Veeken J, Gasteiger G, Rudensky AY.Control of the inheritance of regulatory T cell identity by a cis element in the Foxp3 locus.Cell. 158:749-63, 2014
Josefowicz S, Niec R, Kim HY, Treuting P, Chinen T, Umetsu DT, Rudensky AY. Extrathymically generated regulatory T cells control mucosal Th2 inflammation. Nature. 482:395-9, 2012
Chinen T, Komai K, Muto G, Morita R, Inoue N, Yoshida H, Sekiya T, Nakamura K, Yoshimura A. Prostaglandin E2 and SOCS1 have a role in intestinal immune tolerance. Nat Commun. 2:190, 2011
Takahashi R, Nishimoto S, Muto G, Sekiya T, Tamiya T, Kimura A, Morita R, Chinen T, Yoshimura A. SOCS1 is essential for Treg cell functions by preventing loss of Foxp3 expression as well as IFN-g and IL-17A production. J Exp Med. 208:2055-67, 2011
Chinen T, Volchkov PY, Chervonsky AV, Rudensky AY. A critical role for regulatory T cell-mediated control of inflammation in the absence of commensal microbiota. J Exp Med. 207:2323-30, 2010
Ichiyama K, Yoshida H, Wakabayashi Y, Chinen T, Saeki K, Takaesu G, Hori S, Yoshimura A, Kobayashi T. Foxp3 inhibits RORgt-mediated IL-17A mRNA transcription through direct interaction with RORgt. J Biol Chem. 283:17003-8, 2008
Ogata H, Kobayashi T, Chinen T, Takaki H, Sanada T, Minoda Y, Koga K, Takaesu G, Yoshimura A. Deletion of the SOCS3 gene in liver parenchymal cells promotes hepatitis-induced hepatocarcinogenesis. Gastroenterology. 131:179-93, 2006
Chinen T, Kobayashi T, Ogata H, Takaesu G, Takaki H, Yagita H, Nawata H, Yoshimura A. SOCS1 regulates inflammatory bowel disease in which both IFNg and IL-4 are involved. Gastroenterology. 130:373-88, 2006
Hanada T, Kobayashi T, Chinen T, Saeki K, Takaki H, Koga K, Minoda Y, Sanada T, Yoshimura A. IFNg-dependent, spontaneous development of colorectal carcinomas in SOCS1-deficient mice. J Exp Med. 203:1391-7, 2006
Ogata H, Chinen T, Yoshida T, Kinjyo I, Takaesu G, Shiraishi H, Iida M, Kobayashi T, Yoshimura A. Loss of SOCS3 in the liver promotes fibrosis by enhancing STAT3-mediated TGF-b1 production. Oncogene. 25:2520-30, 2006
Chinen T, Misawa T, Yao T, Nasu T, Yoshida K, Kubo S, Toyoshima S, Sakaguchi T, Harada N. Pedunculated cap polyps preceding the development of cap polyposis: case report. Gastrointest Endosc. 61:338-40, 2005
Chinen T, Misawa T, Yoshida K, Nasu T, Kubo S, Toyoshima S, Yao T, Harada N. Esophageal submucosal gland duct adenoma. Gastrointest Endos. 60:798-9, 2004
Inagaki-Ohara K, Chinen T, Matsuzaki G, Sasaki A, Sakamoto Y, Hiromatsu K, Nawa Y, Yoshimura A. Mucosal T cells bearing TCRgd play a protective role in intestinal inflammation. J Immunol. 173:1390-8, 2004
Yasukawa H, Ohishi M, Mori H, Murakami M, Chinen T, Takeda K, Akira S, Hoshijima M, Hirano T, Yoshimura A. IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages. Nat Immunol. 4:551-6, 2003
総説
荻野 治栄, 田中 義将, 知念 孝敏, 伊原 栄吉
【特殊状況下でのIBD診療を身につける!】担癌患者のIBD診療を身につけるIBD research 17:20-27、2023
荻野 治栄，田中 義将，知念 孝敏，小森 圭司，伊原 栄吉，小川 佳宏
【これだけは知っておきたい消化管疾患の診断・治療】消化管における慢性炎症
消化器クリニカルアップデート 2, 24-28, 2020
知念 孝敏, 和田 将史，濱田 匠平，伊原 栄吉
【消化管症候群(第3版)-その他の消化管疾患を含めて-】食道 遠位食道痙攣日本臨床 別冊, 41-46, 2020
荻野 治栄，田中 義将，知念 孝敏，小森 圭司，伊原 栄吉，小川 佳宏 【これだけは知っておきたい消化管疾患の診断・治療】消化管における慢性炎症．消化器クリニカルアップデート 2, 24-28, 2020
【特殊状況下でのIBD診療を身につける!】担癌患者のIBD診療を身につけるIBD research 17:20-27、2023
荻野 治栄，田中 義将，知念 孝敏，小森 圭司，伊原 栄吉，小川 佳宏
【これだけは知っておきたい消化管疾患の診断・治療】消化管における慢性炎症
消化器クリニカルアップデート 2, 24-28, 2020
知念 孝敏, 和田 将史，濱田 匠平，伊原 栄吉
【消化管症候群(第3版)-その他の消化管疾患を含めて-】食道 遠位食道痙攣日本臨床 別冊, 41-46, 2020
荻野 治栄，田中 義将，知念 孝敏，小森 圭司，伊原 栄吉，小川 佳宏 【これだけは知っておきたい消化管疾患の診断・治療】消化管における慢性炎症．消化器クリニカルアップデート 2, 24-28, 2020